Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Elabela"”.
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Characterisation of the Apelin Receptor and its Endogenous Ligands, Apelin and Elabela/Toddler in the Cardio-Renal System
… binds two peptide ligands, namely apelin and Elabela/Toddler (ELA). Although apelin has been studied in some detail, little is known about the expression and function of ELA, and the renal apelin system. The aim of this study was to characterise the expression of ELA relative to apelin and …
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Identification de déterminants de la relation structure-activité du ligand Elabela liant le récepteur APJ par comparaison entre différentes espèces de mammifères
… deux ligands endogènes, l'Apéline (Ape) et l’Elabela (ELA). Au cours des dernières années, l’axe APJ/Ape/ELA a générée beaucoup d’intérêt sur le plan thérapeutique en raison de son rôle dans de nombreux effets physiologiques et notamment dans le contrôle de la pression artérielle et de la …
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The Identification and Pharmacological Characterisation of Novel Apelin Receptor Agonists In Vitro and In Vivo
… and two endogenous peptide ligands, apelin and elabela. It is implicated as a potential therapeutic for a number of diseases; however, the endogenous peptides are limited by half-life and bioavailability. This study aims to identify and pharmacologically characterise apelin agonists in vitro and …
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Investigating the role of the cardiac apelin receptor using human embryonic stem cell derived-cardiomyocytes.
… its two endogenous peptide ligands, apelin and Elabela, have emerged as key regulators of cardiovascular development, physiology and disease. It has therefore been suggested that targeting the apelin receptor therapeutically may be beneficial for the treatment of a range of cardiovascular …
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Exploring the therapeutic potential of the apelin receptor signalling axis, and angiotensin-converting enzyme 2 (ACE2) as the SARS-CoV-2 viral entry receptor, in the cardiovascular system
… binds two endogenous peptide ligands, apelin and elabela/Toddler (ELA), to induce positive cardiac inotropy and vasodilatation in the cardiovascular system. The apelin receptor provides a tractable therapeutic target for multiple cardiovascular diseases, such as pulmonary arterial hypertension, …