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Showing 1 to 20 of 43 for “"Eicosanoids"”.
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The role of eicosanoids in the human skin's response to ultraviolet radiation.
Erythema is a hallmark skin response to excessive ultraviolet radiation (UVR) and is associated with cutaneous inflammation. Both are mediated by inflammatory mediators including nitric oxide (NO), prostaglandin E2 (PGE2) and chemoattractants such as 12-hydroxyeicosatetraenoic acid (12-HETE) …
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Immunomodulatory Effect Of Host And Fungal Eicosanoids During Host-Pathogen Interactions With Candida Albicans
… that cross-react functionally with host eicosanoids, which are considered to play important role in regulating innate and adaptive immune responses. Our objective was to characterize the role of prostaglandins produced by the host and this fungus during host pathogen interactions, both in …
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Modulation of macrophage tumor necrosis factor-alpha production by omega-3 polyunsaturated fatty acids, eicosanoids, and calcium
Made available in DSpace on 2011-05-07T13:06:27Z (GMT). No. of bitstreams: 2 license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) 9411584.pdf: 5136937 bytes, checksum: e2d5ecc84f036f49d27c51932622b5b8 (MD5) Previous issue date: 1993
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Methyl esterification of fatty acids and eicosanoids with a novel reagent trimethylsilyldiazomethane for analysis by gas chromatography-mass spectrometry
<p>Fatty acids are compounds with limited water solubility that belong to the lipid class of bio-organic compounds and can be utilized as a source of energy by the body or as precursors to oxidized compounds that have roles in inflammation and in the regulation of vascular tone. The prostaglandins …
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Characterization of Bioactive Compounds by Mass Spectrometry and Nuclear Magnetic Resonance
… ESIMS and ESIMS/CID/MS were employed to profile eicosanoids in different cell cultures. Eicosanoids are fatty acid derivatives with a variety of extremely potent hormone-like actions on various tissues of vertebrate animals. Profiling eicosanoids by mass spectrometry has very significant …
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Involvement of eicosanoid signalling in epithelial cell migration
… and the machinery producing them such as the eicosanoids. Changes in the expression of extracellular matrix proteins and their related integrin receptors have also been shown to be important in the advancement IBD and CC. In light of this, we have investigated the role of eicosanoids in cell …
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The Group IVA Cytosolic Phospholipase A2/C1P Interaction and Its Role in Eicosanoid Synthesis and Inflammation
… rheumatoid arthritis, diabetes and asthma. Eicosanoids are well established mediators of inflammation, and the initial rate limiting step in the production of eicosanoids is the liberation of arachidonic acid (AA) from membrane phospholipids by a phospholipase A2 (PLA2). The major …
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A Combined Computational Strategy of Sequence and Structural Analysis Predicts the Existence of a Functional Eicosanoid Pathway in <i>Drosophila melanogaster</i>
… roles in signal transduction and metabolism, eicosanoids have emerged as important players in human health and disease. Mammalian prostanoids and related lipid mediators perform varied functions in different tissues and organs. Synthesized through the oxygenation of C20 polyunsaturated fatty …
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Immune Mediators of Murine Lyme Arthritis
… in eicosanoid production (from AA/LA-derived eicosanoids to EPA/DHA-derived eicosanoids) and promotes antiinflammatory prostaglandin production, disease severity is not altered. (4) We found that eicosanoid production throughout the course of autoantibody-drive K/BxN serum-transfer arthritis …
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Expression and Function of a Putative Cox-Like Gene in D. melanogaster
… primarily at sites of inflammation. While eicosanoids play a major role in inflammation in insects, their existence in fruit flies has not been reported. Recent computational analyses by Qi and Singh (2014) have identified putative COX-like enzymes in the fruit fly Drosophila melanogaster. …
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The Influence of Dietary Fat on The Cerebral Microvasculature: Compositional, Prostaglandin Synthetic, and Permeability Studies
… uptake, and the potential involvement of eicosanoids in the uptake process.
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Signal transduction in macrophages. Intracellular pathways activated by microbial constituents
… mediators. Such mediators are TNF? and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. This thesis is based on studies performed with the use of microbial constituents which induce arachidonate release or/and TNF? …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes and mycobacterium tuberculosis infections in mice
… antigen-presenting cells release cytokines and eicosanoids (including leukotrienes, epoxyeicosatrienoic acids, and prostanoids) to activate adaptive immunity. Leukotrienes (LTs), an eicosanoids subset, are produced from arachidonic acid via 5- lipoxygenase metabolism, resulting in LTB4 and …
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The role of Cysteinyl leukotriene type 1 receptor (CysLTR1) during Listeria monocytogenes infection in mice
… responses. Production of cytokines and eicosanoids by antigen presenting cells activates the adaptive immunity. Eicosanoids (epoxyeicosatreinoic acids, prostanoids and leukotrienes) are generated from metabolites of 20-carbon chained polyunsaturated fatty acids and arachidonic acid. …
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Diversity and characterization of novel Cytochrome P450 2 genes in the marine teleost Fundulus Heteroclitus
… and 135 pmol/nmol CYP/min forming a variety of eicosanoids including epoxyeicosatrienoic acids 14,15-, 11,12-, and 8,9- and hydroxyeicosatrienoic acids 5-, 9-, 11-, 12-, 16-, 19-, and 20-. Eicosanoids, especially arachidonic acid metabolites, have been shown to modulate epithelial salt and water …
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Protein-protein interactions and mechanistic insights for CYP2J2 and CYP5A1
Eicosanoids are signaling molecules formed from the oxidation of -3 and -6 fatty acids. CYP2J2 and CYP5A1 are two key enzymes involved in the formation of eicosanoids. CYP2J2 is a classical P450 which requires transfer of electrons from its obligate redox partner, cytochrome P450 reductase (CPR). …
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The effect of eicosapentaenoic acid on brain and platelet produced bioactive lipid mediators. The effect of eicosapentaenoic acid, docosapentaenoic acid and other polyunsaturated fatty acids on the eicosanoids and endocannabinoids produced by rat brain and human platelets using electrospray ionisation tandem mass spectrometry-based analysis.
… of this study was to examine the production of eicosanoids, hydroxy fatty acids and fatty acid ethanolamides in young and aged rat brain following EPA or DPA enriched diets. The effects of specific PUFA on human platelet eicosanoid production were also investigated as these mediators play a role …
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EVALUATION OF THE OXIDATIVE METABOLITES OF ARACHIDONIC ACID AND THEIR IMPLICATION IN THE PROGRESSION OF INFLAMMATORY DISEASES: HYPERTENSION AND RHEUMATOID ARTHRITIS
… that produces arachidonic acid (AA) metabolites (eicosanoids). Eicosanoids are specific biomarkers of inflammation. Their biosynthesis from arachidonic acid can be catalyzed by either free radicals or enzymes such as lipoxygenases (LOX), cyclooxygenase-2 (COX-2) and cytochrome P450. Depending on …
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Changes In The Testes Following Spinal Cord Injury and The Attenuating Effects of Licofelone
… Dawley rat model, including the elevation in eicosanoids, increased oxidative stress, chronically elevated unconjugated bile acids, altered immune cell populations, acutely decreased testosterone production, and acute elevations in lysolipids. In addition, we show promising and long lasting …
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An examination of the bioactive lipids involved in skin cell inflammation and in response to ultraviolet radiation. Effect of n-3 polyunsaturated fatty acid supplementation on red blood cell and human dermal fatty acid and production of eicosanoids by HaCaT keratinocytes and 46BR.1N fibroblasts following exposure to UVR.
… to assess cellular fatty acids and production of eicosanoids. The clinical a study showed that in RBC saturated fatty acids (SFA) (44.27±7.43%) were the main fatty acid group followed by n-6 PUFA (29.61±5.53%). While in dermal tissue monounsaturated fatty acids (MUFA) (58.90±9.80%) was the main …
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