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Showing 1 to 16 of 16 for “"Ehrlichia chaffeensis"”.
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Eukaryotic protein mimicry as an infection strategy for Ehrlichia chaffeensis
Ehrlichia chaffeensis (E. ch.) expresses the TRP120 multifunctional effector on the surface of infectious dense-cored ehrlichiae which is known to play a role in phagocytic entry, but a cognate host receptor has not been identified. We recently reported that E. ch. activates canonical Wnt signaling …
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Ehrlichia chaffeensis Activates Notch Signaling Through SLiM Mimicry to Inhibit Apoptosis
Ehrlichia chaffeensis is a small, obligately intracellular gram-negative bacterium, and the etiological agent of human monocytotropic ehrlichiosis (HME), an emerging, life threatening tick-borne zoonosis. E. chaffeensis infects mononuclear phagocytes and has evolved molecular strategies to …
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Ehrlichia chaffeensis Type 1 Secreted Effector TRP47 is a Novel SUMOylated Nucleomodulin
Ehrlichia chaffeensis secretes immunodominant and immunoprotective protein effectors into the host cell using a type I secretion system. The best-characterized of these effectors are the tandem repeat proteins (TRPs). In this study, E. chaffeensis TRP47 was identified as a target for host cell …
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TRP75-Mediated STAT3 Activation Promotes Anti-Apoptotic Signaling and Ehrlichia chaffeensis Infection
Ehrlichia chaffeensis is an obligately intracellular bacterium that manipulates mononuclear phagocytes by hijacking host cell signaling pathways to promote infection. In part, E. chaffeensis accomplishes host cell manipulation through the actions of secreted effector proteins, including the tandem …
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Host-Dependent Expression, Transcriptional Regulation and Protection of Ehrlichia chaffeensis Tandem Repeat Proteins
Ehrlichia chaffeensis is an obligately intracellular bacterium that is the causative agent of human monocytotropic ehrlichiosis, an emerging life-threatening zoonosis. E. chaffeensis is transmitted by the lone star tick, Amblyomma americanum, and replicates in mononuclear phagocytes in mammalian …
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Ehrlichia chaffeensis E3 Ligase TRP120 Ubiquitinates Tumor Suppressor FBW7 for Degradation to Promote Infection
Ehrlichia chaffeensis (E. chaffeensis) exploits evolutionarily conserved Notch and Wnt host cell signaling pathways to downregulate innate immune host defenses and promote infection. The multifunctional E. chaffeensis TRP120 effector which has HECT E3 ubiquitin ligase activity, interacts with the …
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The role of the P28 multigene family in the pathogenesis of Ehrlichia chaffeensis infection.
<i>Ehrlichia chaffeensis</i> is a gram-negative obligate intracellular bacterium which parasitizes cells of the monocyte/macrophage lineage in mammals. <i>E. chaffeensis</i> possesses a unique cell wall that lacks LPS and the classical peptidoglycan found in other gram-negative bacteria. …
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Ehrlichia chaffeensis mediates Hedgehog and Hippo signaling to activate an anti-apoptotic cellular program
Ehrlichia chaffeensis is a gram-negative intracellular bacterium responsible for the emerging zoonotic disease, human monocytic ehrlichiosis (HME). HME is the most prevalent and life-threatening tick-borne disease in the United States. In the past two decades, the incidence of HME has increased …
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A Molecular Survey of Ehrlichia Chaffeensis and Ehrlichia Ewingii in Dogs and Ticks From Southwest Missouri
… disease that is caused by bacteria of the genus Ehrlichia. Previous studies have suggested that dogs may serve as reservoirs for some species of Ehrlichia. Nested-PCR was used to survey for the presence of Ehrlichia chaffeensis and Ehrlichia ewingii in blood samples of 37 tick-infested dogs from …
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Ehrlichia chaffeensis TRP32 is a Nucleomodulin that Regulates Host Gene Expression and Post-Translational Modifications Determine its Localization and Function
Ehrlichia chaffeensis is an obligately intracellular bacterium that reprograms the mononuclear phagocyte through diverse effector-host interactions to modulate numerous host cell processes, including transcription. Previously, we reported that E. chaffeensis TRP32, a type 1 secreted effector, …
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Ehrlichia chaffeensis TRP47 enters the nucleus via a MYND-binding domain-dependent mechanism and predominantly binds enhancers of host genes associated with signal transduction, cytoskeletal organization, and immune response
Ehrlichia chaffeensis is an obligately intracellular bacterium that establishes infection in mononuclear phagocytes through largely undefined reprogramming strategies including modulation of host gene transcription. In this study, we demonstrate that the E. chaffeensis effector TRP47 enters the …
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Elucidating the Molecular Function of Reprolysin Metalloproteases in Tick-Host-Pathogen Interaction
… is a carrier of multiple diseases, including <em>Ehrlichia chaffeensis</em>, the causative agent of Human Monocyte Ehrlichiosis. This experiment consisted of two main goals: the first was to characterize <em>A. americanum</em> Reprolysin Metalloproteases, and the second to gain a better insight …
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Tick Infestations and Their Consequences for Migratory Songbirds During Spring Stopover
… and analyzed via PCR for the presence of <em>Ehrlichia chaffeensis</em>, causative agent of the tickborne disease ehrlichiosis, to determine if ticks and their associated pathogens are capable of being transported to North America by way of migrating birds. We found that 27 (10.2%) of 252 …
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Tick abundance and microorganism diversity in the 11 counties comprising the Choctaw Nation of Oklahoma
… detected in Ix. scapularis. In A. americanum, Ehrlichia chaffeensis (0.4%), Ehrlichia ewingii (0.6%), Panola Mountain Ehrlichia (0.12%) and Borrelia lonestari (0.6%) were detected. Overall, detection rates of these microorganism were below those historically reported in humans across the …
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Ehrlichiosis: Understanding immune mechanisms that lead to the development of fatal disease
The clinical manifestations of HME caused by Ehrlichia chaffeensis, a Gram-negative, LPS-lacking bacterium, including toxic shock-like syndrome and liver injury in the absence of overwhelming bacterial burdens, has led to the hypothesis that severe disease is immune-mediated. Our previous studies …
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Determining the Prevalence and Distribution of Tick-Borne Pathogens in Southeastern Virginia and Exploring the Transmission Dynamics of Rickettsia Parkeri in Amblyomma Maculatum
… pathogens, including Rickettsia parkeri and Ehrlichia chaffeensis.</p> <p>The second aim of this research was to determine the transmission dynamics of Rickettsia parkeri within its vector, Amblyomma maculatum. Although some rickettsiae are transovarially transmitted in ticks, little is known …