Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Eflornithine"”.
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The Role of S-Adenosylmethionine Synthetase in Killing Effects of DFMO in African Trypanosomes
… of a functional AdoMetSyn in the toxic effect of eflornithine, a clinically used therapy for the treatment of the disease. Prior studies suggested that the toxicity of eflornithine may be due to the combined effect of polyamine depletion and detrimental effects of increased levels of AdoMet in the …
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Nitroaromatic pro-drug activation and resistance in the African trypanosome
… such as nifurtimox (in combination with eflornithine) and fexinidazole (in clinical trials), have been recently introduced for the treatment of the second stage of sleeping sickness. These compounds are believed to act as pro-drugs that require intracellular enzymatic activation for …
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Factors influencing the spread and selection of drug resistance in Human African Trypanosomiasis
… rational or alternating use of melarsoprol and eflornithine (DFMO) to ensure a longer life for eflornithine, delaying the onset of resistance. Insight into the overall population structure of the T. b. gambiense from Omugo, Arua (N=54) and Moyo (N=17) was obtained using mini/microsatellite …