Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Efflux transporter"”.
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To Investigate The Impact Of Gut Bacteria On Efflux Transporter Expression And Function In Gastrointestinal Mucosae
… a widely used probe to monitor P-gp mediated efflux activity, in organoids was determined with and without the presence of P-gp inhibitors Cyclosporine A and LY335979. The uptake of calcein-AM was higher within the enterocytes of humanized mice colonoids compared to those obtained from germ …
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An Investigation of The Use of Dendrimer-Based Carrier to Cross Cellular Barrier
… that is a substrate of P-glycoprotein (P-gp) efflux transporter with low water solubility. This thesis described the syntheses, characterisations and biological evaluations of the dendrimer-based drug delivery system to overcome the cellular barriers. G3 PAMAM dendrimers were conjugated with …
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Placental P-glycoprotein: Role in disposition of medications administered during pregnancy
… the maternal and fetal circulation. Active efflux transporters in the placental apical membrane are involved in placental elimination of compounds and thus fetal protection. The goal of this investigation was to evaluate developmental and genetic influences on expression and activity of the …
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Structural mechanism for multidrug efflux systems
… heavy metal ions, is the expression of membrane efflux transporters that recognize and actively export these toxic compounds out of bacterial cells, thereby allowing them to survive in extremely toxic conditions. Many of these transporters are multiple drug binding proteins which extrude …
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Three-dimensional Hyaluronan-based Hydrogels Designed for Breast Cancer Spheroid Formation
… expressed multidrug resistance protein 1, a drug efflux transporter on bifunctional HA hydrogels, and showed decreased doxorubicin drug penetration. Secondly, HA-oxime hydrogels were designed with tunable gelation to encapsulate breast cancer cells. We compared the culture of 5 different cell …
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Genetic Determinants of ABCB1 Promoter Activity and Their Effects on Environmental Exposure
… problems as well as cancer later in life. Efflux transporters, which are highly expressed in the human placenta, are key regulators of placental xenobiotic transfer from the maternal to the fetal circulation. A major placental efflux transporter is P-gp, which is encoded by the ABCB1 gene. …
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Using Dictyostelium discoideum to develop flavonoid therapeutics for polycystic kidney disease: the role of MATE transporters
… activity of two novel multidrug and toxin efflux (MATE) transporters. Their role in biological and biomedical implications of flavonoid transport in this model microbe are considered in the light of the evidence for naringenin specifically inhibiting cyst-forming kidney disease. D. …
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The Expression of Copper Transporters in Rat Dorsal Root Ganglion Neurons and its role in Oxaliplatin Neurotoxicity
… unknown. Recent evidence suggests that copper transporters may be implemented in the transport and neurotoxicity of platinum drugs. We hypothesis that platinum drugs induce neurotoxicity by mechanisms involving copper transporters. To examine the mechanisms by which dorsal root ganglia neurons …
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Advancing Precision Medicine in Psychiatry: Genetic Insights into Antidepressant Treatment Outcomes
… enzyme) and ABCB1 (encoding the drug-efflux transporter P-glycoprotein), and broader polygenic liability may partly explain this variability. Recent advances in psychiatric genomics have enabled the use of polygenic risk scores (PRSs) to quantify the cumulative genetic predisposition …
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MRP4-Dependent Regulation of Fibroblast Migration
… the large family of ATP binding cassette (ABC) transporter proteins, that localizes to the plasma membrane and functions as a nucleotide efflux transporter and thus plays a pivotal role in the regulation of intracellular cyclic nucleotide dynamics. In our study we used MRP4-expressing fibroblast …
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The pharmacologenetics of lopinavir in a cohort of black African HIV/AIDS patients
… enzymes, CYP3A4 and CYP3A5; the hepatic uptake transporter, OATP1B1; and the efflux transporter, MRP2. Variation in the genes encoding these proteins may influence their functioning and hence LPV disposition. The aim of the study was to identify significant single nucleotide polymorphisms (SNPs) …
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Mitochondrial Function as a Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas
… without other modulations being observed, and efflux transporter expression explaining drug resistance. Drug resistance was the most consistent quality marker and is related to clinical use. Implications, further tests and generation of a mitochondrial functional testing pipeline are presented.
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NSAIDs Modulate Morphine Transport at the Blood-Brain Barrier: A Role for P-glycoprotein
… expression and activity of the ATP-dependent efflux transporter P-glycoprotein (P-gp) that is endogenously expressed at the blood-brain barrier (BBB). Increased P-gp functional expression was associated with a significant reduction in CNS uptake of morphine and, subsequently, reduced morphine …
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BIOCHEMICAL ACTIONS OF A NOVEL CIS-TERPENONE
… this effect we first determined whether specific transporters affect the accumulation of AFB1 in HepG2 cells. Effects on AFB1 accumulation by pH, selected ions, inhibitors or competitive substrates of organic cation transporters (OCT), organic anion transporters (OAT/OATP), and …
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Regulation of P-glycoprotein at the Blood-Brain Barrier
… element of barrier function is the ATP-driven efflux transporter, P-glycoprotein (P-gp) that denies CNS entry to a myriad of therapeutics. Thus, a better understanding of the mechanisms regulating P-gp expression and transport function might provide new strategies to improve drug delivery to …
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Multidrug resistance-associated protein 2 (MRP2) and oxaliplatin transport
… clinical treatment of gastrointestinal cancer. Efflux membrane transporters have been reported to play roles in determining the cellular accumulation and activity of platinum-based drugs, but there have been few studies of oxaliplatin. We hypothesized that the efflux transporter multidrug …
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Investigation of surfactant-drug pharmacokinetic interactions
… a substrate of the P-glycoprotein (P-gp) efflux transporter with fluorescent properties, was measured in the presence of five surfactants and a bile salt, namely Brij® 58, Tween® 20, Span® 20, Cremophor® CO40 and sodium deoxycholate. The surfactants were added at three different …
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ROLE OF OXIDATIVE REACTIVE SPECIES AND ANTIOXIDANTS IN METABOLISM AND TRANSPORT OF THERAPEUTIC DRUGS
… species on the active transport mediated by ABC efflux transporters as well as exploring the possibility of using antioxidants not as interceptors of reactive species but rather as inhibitors of metabolic enzymes and transporters. The BCRP/ABCG2 efflux transporter was selected for the …
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Novel Strategies towards the Inhibition of ATP-Binding Cassette (ABC) Transporters from Pathogenic Bacteria
Multidrug transporters in the ATP-Binding Cassette (ABC) superfamily play critical roles in pathogenic bacteria. These transport systems are particularly important in conferring antibiotic resistance on the cell by mediating the efflux of a wide range of structurally unrelated compounds and the …
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Integrative high-throughput analyses of aerial morphodynamics in plants
… to identify the patterning of the auxin efflux transporter PIN1 in plant shoots, specifically in the context of flower organ initiation. A method is developed to investigate molecular patterning data of PIN1 from many samples, in 3D. The results indicate that PIN1 patterning is tightly …
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