Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Efferocytosis"”.
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Mechanisms of Impaired Efferocytosis of Synovial Macrophages in Knee Osteoarthritis
… research from the Appleton lab has shown that efferocytosis, the process for the clearance of dead and dying cells by macrophages, is impaired in OA patients. This project further explored the OA-specific mechanisms controlling efferocytosis in macrophages and investigated whether there was …
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An unbiased proteomic approach to identifying cell surface markers in neutrophils
Introduction: Efferocytosis refers to the engulfment of dead cells by phagocytes such as neutrophils and macrophages and culminates in the beneficial removal of inflammatory cargo and auto-reactive material. While many of the mechanisms involved in efferocytosis have been described, the critically …
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Exosomal Communication By Metastatic Osteosarcoma Cells Modulates Alveolar Macrophages to An M2 Tumor-Promoting Phenotype and Inhibits Tumoricidal Functions
… of M2 macrophages) and decreased phagocytosis, efferocytosis, and macrophage-mediated tumor cell killing. In contrast, exosomes from non-metastatic<em> </em>K7 or Dunn cells did not inhibit phagocytosis, efferocytosis, and macrophage-mediated cytotoxicity or induce increased expression of IL10, …
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Age-Dependent Determinants of Blood-Derived Monocytes Influence Neuroinflammatory Milieu at the TBI Injury Site
… monocytes are capable of performing efferocytosis, the immunologically silent engulfment of cellular debris, which is critical for removing hazardous cellular corpses and concurrently resolving inflammation. Age-at-injury profoundly effects TBI recovery outcomes also. The phenotypic …
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Impact of cationic host defence peptide LL-37 on human neutrophil death and inflammatory responses
… is critical to innate immunity, and the efferocytosis of apoptotic PMN, in contrast to necrotic cells, is proposed to promote the resolution of inflammation. In this thesis I demonstrate that the human cathelicidin LL-37 rapidly induced secondary necrosis of apoptotic human PMN and …
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The cholesterol efflux protein ABCA1 skews macrophages towards an anti-tumor phenotype and consequently impacts cancer progression
… (2) decreasing angiogenesis, (3) decreasing efferocytosis—an immune-suppressive phagocytic process devoid of antigen presentation, and (4) enhancing the expansion, migration, and activity of cytotoxic T cells. The culmination of these attributes were demonstrated by our observations that …
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Investigating milk cell population changes in response to heat stress and characterizing functionality of epithelial cells in milk of lactating dairy cows
Understanding the number of mammary epithelial cells a cow maintains is essential to maximize milk synthesis in lactating dairy cows. This thesis aimed to investigate milk cell population changes in lactating dairy cows in response to heat stress (HS) using a pair-feeding model (PFTN). …
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Molecular Mediators of Macrophage Foam Cell Formation and Atherosclerosis and their Pharmacological Modification
… such as polarisation, viability, phagocytosis, efferocytosis or CC-induced activation of the NLRP3 inflammasome. Chapter 5 explored the effect of knocking out eEF2K in a mouse model of atherosclerosis, induced by high cholesterol diet feeding on the pro-atherogenic Ldlr-/- background. We first …