Global ETD Search
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Showing 1 to 12 of 12 for “"Effects of drugs on"”.
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Measuring the effects of drugs on single cancer cell growth
Understanding the effectiveness of a drug therapy on halting disease progression is an essential aspect of cancer biology. Conventional assays that study cell behavior after a drug intervention report the average response of a cell population which can mask the heterogeneity and dynamics of …
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EFFECTS OF DRUGS ON EXTRACELLULAR ARGININE LEVEL IN THE CEREBELLUM OF RAT
The ubiquitous nature of NO and its roles as a vasodilator and as an effector molecule in immunological reactions have implicated its function in many physiological and pathophysiological systems. In the neurochemical system, NO is believed to be involved in the transduction mechanism between …
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Microfluidic platforms to evaluate the effects of drugs on fertility and proteins on cancer progression – a focus on cisplatin, alpha-smooth muscle actin, and glial cell line-derived neurotrophic factor
The introduction of in vitro systems that can mimic organ physiology and allow studying the progression of diseases such as cancer is necessary to get reliable information about cell responses and test drug efficacy and toxicity. Classical cell culture systems facilitate a wide range of clinical in …
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Effects of maternal Bromocriptine and Melatonin treatments on fetal development : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science in Animal Science at Massey University, Palmerston North, New Zealand
A previous study (Jenkinson et al., 1994) has proposed that lowered birth weights of autumn (May)-born lambs compared with those of spring (August)-born lambs are due to a direct seasonal effect on placental size, which in turn mediates a slower fetal growth. The effect of season on placental and …
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Validating the therapy prediction model through a breakdown analysis on ICU patient medical records
With the rapid advancement of computational data analysis tools, medical informatics has emerged as a discipline that explores the use of medical information in clinical practice. It searches for ways to effectively integrate as much information as is available to physicians when they make clinical …
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Influence of Fibroblasts on Metastatic Cancer Cell Drug Resistance in a 3D Microfluidic Cell Array
<p>Modeling an accurate depiction of the tumor microenvironment, (TME), is essential to observe the effect external factors might have on the tumor <em>in vivo.</em> In cancer therapy specifically, the outcomes of clinical treatments are heavily dependent on drug testing methods despite the …
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Multiple Electrode Recording of Cardiac Activation.
Cardiac activation has been the subject of much research since its first practical clinical recording by Wilhelm Einthoven who in 1903 produced an electrocardiogram using a string galvanometer. This report describes a multiple electrode device which has been used to record the electrical activation …
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Cell compliance: cytoskeletal origin and importance for cellular function.
Mechanical properties of cells, mainly defined by their cytoskeleton, are closely related to cell function and can be measured with a dual-beam laser trap (optical stretcher). Functional changes, which go hand in hand with changes of the cytoskeleton, also occur during differentiation of stem …
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Gene Expression–Based Algorithms For The Identification of Drug Combinations In Personalized Medicine
… -guid-6f627f44-7fff-efca-53de-883ae04bb7c3">Three of the major problems facing cancer therapeutics are 1) drug resistance, the intrinsic or acquired ability of cancer cells to evade the effect of the therapies used to treat them; 2) heterogeneity among individual patients’ disease at the molecular …
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Sex differences in PFC-related behavior after amphetamine exposure and across adolescent development
Adolescence is a time of experimentation and risk taking. Experimentation with drug use during this period can have especially harmful consequences, however, as adolescent-onset substance use is more likely to lead to dependence. Brain regions within the mesocorticolimbic circuit are involved in …
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Metabolomics and chemical library screening for antibacterial drug discovery
… are polar analytes and are difficult to separate on traditional silica based stationary phases in reverse phase chromatography to allow accurate quantification in their natural form. In part I of this dissertation, we investigated the use of a chiral derivatizing reagent known as Marfey’s reagent, …
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Effects of drugs which alter blood cell deformability in circulatory shock produced by endotoxin
… The drug is said to improve tissue oxygenation in chronic vascular occlusive disease by increasing RBC deformability and has been reported to improve survival in experimental hemorrhagic, septic and endotoxic shock. In the present investigation, the effects of pentoxifylline on …