Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Effects of drugs"”.
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Measuring the effects of drugs on single cancer cell growth
Understanding the effectiveness of a drug therapy on halting disease progression is an essential aspect of cancer biology. Conventional assays that study cell behavior after a drug intervention report the average response of a cell population which can mask the heterogeneity and dynamics of …
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EFFECTS OF DRUGS ON EXTRACELLULAR ARGININE LEVEL IN THE CEREBELLUM OF RAT
The ubiquitous nature of NO and its roles as a vasodilator and as an effector molecule in immunological reactions have implicated its function in many physiological and pathophysiological systems. In the neurochemical system, NO is believed to be involved in the transduction mechanism between …
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Effects of drugs which alter blood cell deformability in circulatory shock produced by endotoxin
… shock. In the present investigation, the effects of pentoxifylline on endotoxin-induced mortality, disseminated intravascular coagulation (DIC), hypotension, and reduction in blood cell deformability were studied in awake rats and compared with the effects produced by two other xanthine …
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Interrupting malaria transmission: the effects of drugs and immunity on the transmissinility of plasmodium falciparum.
Contains fulltext : 30238_intematr.pdf (Publisher’s version ) (Open Access)
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Cortical Eeg Following Bilateral Lateral Hypothalamic Damage: Effects of Drugs Acting on Some Components of the Reticular Formation (Hippocampus, Animal-Model, Pharmacology)
… behaviorally asleep) and show cortical EEG of high voltage and slow waves (HVS) all the time. The failure to maintain cortical low voltage and fast EEG (LVF) as the normal rat does, may reflect disruption of some neurotransmitter components of the reticular formation known to contribute to …
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Microfluidic platforms to evaluate the effects of drugs on fertility and proteins on cancer progression – a focus on cisplatin, alpha-smooth muscle actin, and glial cell line-derived neurotrophic factor
The introduction of in vitro systems that can mimic organ physiology and allow studying the progression of diseases such as cancer is necessary to get reliable information about cell responses and test drug efficacy and toxicity. Classical cell culture systems facilitate a wide range of clinical in …
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ASSESSING THE EFFECTS OF KETAMINE AND ITS ENANTIOMERS ON COMPULSIVE-LIKE AND DEPRESSIVE-LIKE BEHAVIOR
… disorder (OCD) is a common and often serious disorder that can impair a person’s ability to function and live a normal life. The current first line treatments for OCD are serotonin reuptake inhibitors (SRIs), cognitive behavioral therapy (CBT), or a combination of these …
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REDOX-RESPONSIVE POLYMER DELIVERY SYSTEMS FOR ANTI-CANCER DRUG AND IMAGING
Cancer is one of the major human killers. Delivery systems for anti-cancer drugs and imaging agents play important roles in cancer treatment and diagnosis. For development of safe and efficient delivery systems, stimuli-responsive polymers which undergo significant physical or chemical properties …
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Drug Use and Harm Reduction: Community Readiness As Pathway To Well-Being And Reintegration
… abuse negatively impacts the life and well-being of those who use drugs; this harm often extends to their loved ones, communities, and society. One presumptive set of psychological explanations for drug abuse is an addictive personality, a psychological susceptibility resulting from challenging …
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Chemotherapeutic drugs, 5-fluorouracil and cisplatin, differentially affect exprssion of drug metabolising enzyme genes in an oesophageal cancer cell line
Cancer is a leading cause of death worldwide. Oesophageal cancer in particular is the sixth most common cause of cancer deaths globally and its incidence and mortality rates in Southern Africa are among the highest in the world. One of the major challenges with cancer treatment is the vast …
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Validating the therapy prediction model through a breakdown analysis on ICU patient medical records
With the rapid advancement of computational data analysis tools, medical informatics has emerged as a discipline that explores the use of medical information in clinical practice. It searches for ways to effectively integrate as much information as is available to physicians when they make clinical …
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Impact on Endogenous Neural Stem Cells and Neurogenesis by Drugs of Abuse: From Fetal Neurodevelopment to the Adult Brain
Neural stem cells (NSCs) are a subpopulation of cells, found within the fetal and adult brain, that are integral to brain development, maintenance, and repair. Neurogenesis is the process through which NSCs proliferate and differentiate to create new neural cells within the central nervous system. …
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Diverse Kappa Opioid Receptor Agonists: Relationships Between Signaling and Behavior
<p>The opioid system, comprised mainly of the three opioid receptors (kappa, mu and delta) and their endogenous neuropeptide ligands (dynorphin, endorphin and enkephalin, respectively), mediates mood and reward. Activation of the mu opioid receptor is associated with positive reward and euphoria, …
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Influence of Fibroblasts on Metastatic Cancer Cell Drug Resistance in a 3D Microfluidic Cell Array
<p>Modeling an accurate depiction of the tumor microenvironment, (TME), is essential to observe the effect external factors might have on the tumor <em>in vivo.</em> In cancer therapy specifically, the outcomes of clinical treatments are heavily dependent on drug testing methods despite the …
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Effects of maternal Bromocriptine and Melatonin treatments on fetal development : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science in Animal Science at Massey University, Palmerston North, New Zealand
… 1994) has proposed that lowered birth weights of autumn (May)-born lambs compared with those of spring (August)-born lambs are due to a direct seasonal effect on placental size, which in turn mediates a slower fetal growth. The effect of season on placental and fetal development is established …
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Funktionsbasierte Isolierung von Subproteomen mit trifunktionellen Fangverbindungen
Isolation, identification and quantitation of functional subproteomes by use of trifunctional capture compounds™, followed by mass spectrometric analysis, is a relatively new, promising technology for proteomic research. Particularly for analysis of effects and side effects of drugs or plant …
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Multiple Electrode Recording of Cardiac Activation.
Cardiac activation has been the subject of much research since its first practical clinical recording by Wilhelm Einthoven who in 1903 produced an electrocardiogram using a string galvanometer. This report describes a multiple electrode device which has been used to record the electrical activation …
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Scaffold Perception, ComPharmacophore Model Development, And Quantitative Structure-Affinity Relationships Of Sigma Site Ligands
… ischemia, the psychological and convulsive effects of drugs of abuse, and as an imaging agent for cancerous tissues, among others. Drug design efforts targeting these receptors have been hindered by a lack of structural information of the receptors themselves. Traditional ligand-based …
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Possibili differenze sesso-specifiche nella vulnerabilità alle sostanze d’abuso in età adulta dopo esposizione al Δ9-tetraidrocannabinolo durante l’adolescenza
… (Realini et al., 2009). Epidemiological evidence of cannabis use before other drugs has reinforced the idea of the "Cannabis gateway hypothesis" according to which early exposure to cannabis increases the risk of starting the use of harder drugs, such as heroin, cocaine and amphetamine (Kandel, …
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A Capability Approach to Examining the Effects of Actual and Anticipated Fear of Crime: Experiences and Perceptions of Black Female Youth in the Cape Flats
The purpose of this study was to examine how the fear of crime affects the capabilities, perceptions and experiences of black female youth, living in the Cape Flats, Cape Town. Qualitative semi structured interviews were conducted with 18 black female participants between the ages of 18 to 30. This …
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