Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Effector domain"”.
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Functional Analysis of the Molluscum Contagiosum Virus MC160 Death Effector Domain-Containing Protein RxDL Motif
… MCV immune evasion genes. MCV encodes two death effector domain (DED) containing proteins, MC159 and MC160. DEDs are found in cellular proteins such as FADD and procaspase-8. These cellular proteins are involved in several innate immune responses such as apoptosis and activation of interferon …
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The role of the interaction of the influenza B virus NS1 protein with the cellular Brd2 protein
… ~30% of influenza virus infection per year. The effector domain of the NS1 protein of influenza B virus (NS1B protein), encompassing the carboxy terminal two thirds of the protein, suppresses interferon-β (IFN-β) synthesis in virus-infected cells by unknown mechanism(s). The induced IFN-β …
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Structural and Functional Analysis of HIV-1 Nef Activation of PAK-2
… and 191 were identified to be components of an effector domain required for Nef mediating PAK-2 activation with lesser contributions from position 85 and 188. H89 and F191 are highly conserved in subtype B Nefs (LHKF), however in subtype E Nef F89 and R191 predominate. Subtype E Nefs also …
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Investigation of Diverse CARF Effectors in Type III CRISPR - Cas Immunity
<p>All domains of life can be infected by viruses. The simplest forms of life, bacteria, are outnumbered by their viruses, called bacteriophage or phage, by 10 to 1. It is estimated there are more phages on Earth than stars in the sky. Phage act as parasites to bacteria by ejecting their DNA into …
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Die Rolle des Proteins DEDD in Apoptose
… wie die Todeseffektor-Domäne („death effector domain“, DED), kennzeichnen Moleküle, die Schlüsselfunktionen im Rahmen der Apoptose besitzen. Eines dieser Proteine ist DEDD, das aufgrund seiner starken Konservierung und seiner Abundanz eine Sonderstellung innerhalb der …
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MacMARCKS and the Protein Kinase C Signal Transduction Pathway: Role in Neural Secretion and Neural Development
… A dominant-negative mutation in the MacMARCKS effector domain which abolishes PKC-dependent phosphorylation is associated with changes in cellular morphology and blocks agonist evoked exocytosis in PC12 cells. Characterization of the MacMARCKS promoter is presented in Chapter 5. The LPS …
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Bioinformatics Discovery And Functional Characterization Of Lipid-Binding Lov Photoreceptors
The light–oxygen–voltage sensitive (LOV) domain subset of the PAS superfamily is a ubiquitous photoreceptor class that enables organisms across multiple kingdoms to sense blue light. LOV photoreceptors are modular flavin-binding proteins that consist of discrete sensor and effector domains. …
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Translational initiation controls localization and regulatory function of the gamma-herpesviral protein kaposin
… direct repeats, DR2 and DR1, followed by a short domain originally referred to as open reading frame (ORF) K12. Translational initiation at multiple alternative CUG and one AUG start codons causes expression of a gradient of kaposin molecules with varying length and targeting motifs from one …
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Signal Transduction Mechanisms Of Pas And Hamp Domains
… signaling mechanisms employed by PAS and HAMP domains, which are widespread signaling modules that coordinate cellular metabolism with external stimuli. A subset of PAS domains directly sense external stimuli, through an associated cofactor or ligand, and regulate the activity of an attached …
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Computational studies of biomolecules to explore potential therapeutics for COVID-19 and SAMD9- associated diseases
… was carried out for the C-terminal dimerization domain of SARS-CoV-2 nucleocapsid protein and SHetA2, the parent compound of flexible heteroarotinoids. The functionally important residues involved in the docking interactions aligned with the results obtained using ¹⁵N-HSQC NMR titration …
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Entamoeba histolytica-induced Activation of Caspase-4 Regulates Gasdermin D Cleavage to Mediate IL-1β Secretion in Macrophages
… leading to the insertion of N-terminal effector domain into the cell membrane, driving both pore formation and IL-1β secretion without causing significant cell death. In this study, I interrogated the requirements and molecular mechanism for Eh-induced caspase-4 activation in cleaving …
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Characterization of the anti-inflammatory effects of the Molluscum Contagiosum MC159 protein
… Mutational analysis revealed that either Death Effector Domain (DED), a protein:protein interaction domain, of the MC159 protein was sufficient for inhibition. Finally, I show homologs of MC159 including MCV MC160 and cellular FLIPL, inhibit IFN-β expression, suggesting DEDs are important for …
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Nuclear translocation of Gasdermin D (GSDMD) sensitizes chemotherapy through inhibiting PARP-1 in colorectal cancer
… pyroptosis of monocytes, through its N-terminal effector domain cleaved by activated inflammatory caspases to form pores on cell membrane. However, as the universally expressed protein in cancer cells, its function beyond pyroptosis, the pyroptotic function and pyroptosis-independent function of …
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Structural Basis of Signal Transduction within Environmental Sensing PAS Regulated Ser/Thr Kinases
… within a sensory domain that senses various stimuli and alters the functional activities of downstream effectors. This study focused on the superfamily of <strong>PAS</strong> (<strong>P</strong>er-<strong>A</strong>RNT-<strong>S</strong>im) environmental sensory …
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Protein Engineering for Biomedical Materials
… sequence of the leucine rich repeat (LRR) domain of the NOD family of cytoplasmic innate immune system receptors. Innate immunity receptors have been described as pattern recognition receptors in that they recognize "global features" of a family of pathogens versus one specific antigen. In …