Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 85 for “"Effector Functions"”.
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Antibody-Effector Functions in Antiviral Response
… (Fc) domain with Fc receptors (FcR) on effector leukocytes is essential for proper immunological function and bridges the humoral with the cellular components of immunity. While the Fc domain of immunoglobulin G (IgG) has historically been considered to be relatively constant, recent …
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Engineering aglycosylated antibody variants with immune effector functions
… the engagement and activation of immune effector cells - mediated by the interaction of the conserved Fc regions of the antibody with the Fc gamma receptors (Fc[gamma]Rs) on immune cells - is critical to the efficacy of several. This thesis describes the engineering of antibody Fc domain …
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Regulation of T cell effector functions in the intestinal mucosa
… on antigen presenting cells (APCs). The effector functions of CD8+ T cells includes the MHC-I dependent recognition and lysis of target cells (e.g. virally infected cells) through the release of degranulating cytotoxic mediators but CD8+ T cells can also acquire suppressive functions …
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Type I Interferon Mediates Th2 Reprogramming and Acute Suppression of Effector Functions
… that play a role in regulating many biological functions, including suppressing viral replication and modulating adaptive immune functions. Although IFN-α/β has been extensively studied regarding the activation of interferon sensitive genes, much less is known regarding its role as a negative …
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THE ROLE OF P2X7R IN METHAMPHETAMINE-INDUCED BEHAVIORAL CHANGES AND MICROGLIAL EFFECTOR FUNCTIONS
… mechanisms contribute to altered microglia effector functions during stimulant abuse, and that modulating the glial response during addiction may have potential therapeutic implications.
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Identification of genes involved in macrophage activation and effector functions against intracellular pathogens
… dissertation was to identify these macrophage effector genes and to functionally characterize their role during infection utilizing gene deficient mouse models. Since mice deficient for C/EBPβ (C/EBPβ-/-) expressed normal levels of IFN-y and TNF during Listeria monocytogenes infection, the …
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RNA binding proteins ZFP36 and ZFP36L1 limit CD8+ T cell differentiation and effector function
… the ZFP36 proteins in the differentiation and effector functions of CD8+ T cells remain to be explored. My project utilized mice featuring the OT-1 transgenic T cell receptor to produce cytotoxic T lymphocytes (CTLs) and memory-like CD8+ T cells in vitro. I made use of knockout mouse models …
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Delineating The Immunometabolism Of Human Invariant Natural Killer T Cells
… influence their ability to survive and maintain effector functions within the harsh, nutrient-poor solid tumor microenvironment (TME). In conventional T cells (TCONV), naïve, effector, and memory differentiation states are characterized by unique metabolic properties and bioenergetic demands that …
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Visualizing the dynamics of HIV-specific cytotoxic T-cells in extracellular matrix
… While molecular mechanisms of CTL antiviral effector functions have been established in vitro, they have been defined in the absence of physiological dynamics and migration. Furthermore, longterm dynamics of single cells have been inaccessible in vivo, where brief imaging durations have been …
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Blocking Immunosuppressive Factors and Taking Advantage of the Nutrient Supply Within the Tumor Microenvironment: Pathways to Achieve Improved Cancer Immunotherapeutic Efficacy for Patients With Metastatic Melanoma
… ligands within the TME impair T cells’ effector functions. I assessed whether blocking immunoinhibitory signaling during T cell priming augments their antitumor activity. I designed a melanoma vaccine expressing MAAs within herpes simplex virus (HSV) glycoprotein D (gD), which blocks the …
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LINOLEIC ACID UNLEASHES THE ANTI-TUMOR POTENTIAL OF CD8 T CELLS BY PROMOTING METABOLIC REPROGRAMMING
… whether all lipids are detrimental to T cell functions and how they regulate different fate decisions remains poorly understood. Here, we identified Linoleic Acid (LA) as a major positive regulator of CTL activity. LA endows CTL with improved metabolic fitness and redirects them away from …
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The RNA-Binding protein PTBP1 plays a role in the activation of mouse CD8 T cells
… growth, clonal expansion, and acquisition of effector functions. These steps are a result of controlled gene expression changes dependent on transcriptional and post- transcriptional mechanisms. These processes are tightly regulated, but little is known about the mechanisms through which these …
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IL-1R8: A Novel Checkpoint Regulating Anti-Tumor And Anti-Viral Activity Of NK Cells
… its potential role in controlling NK cell effector functions.<br></br><br></br>Expression analysis showed that IL-1R8 was acquired during differentiation in human and murine NK cells. IL-1R8 deficiency in the mouse was associated with higher frequency and absolute number of mature NK cells …
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Modulation of CD8+ T Cell Function by Beta2-Adrenergic Receptor Signaling
… ADRB2 signaling on the differentiation and acute effector functions of CD8+ T cells remains poorly understood. More importantly, its effect on CD8+ T cell memory development remains elusive. Therefore, I comprehensively addressed the role of ADRB2 signaling on different aspects of CD8+ T cell …
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… mediated regulation of CD4<sup>+</sup> Th17 effector cells as exemplified by diminished levels of IL-17 and decreased neutrophilic infiltration in the airways. In contrast, co-transfer of nTregs did not attenuate the lung inflammation elicited by CD4<sup>+</sup> Th2 or Th1 polarized cells. …
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… mediated regulation of CD4<sup>+</sup> Th17 effector cells as exemplified by diminished levels of IL-17 and decreased neutrophilic infiltration in the airways. In contrast, co-transfer of nTregs did not attenuate the lung inflammation elicited by CD4<sup>+</sup> Th2 or Th1 polarized cells. …
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Regulation of Human Cytotoxic T Lymphocyte Functions by IL-12
… against intracellular pathogens by secreting effector cytokines and directly killing infected cells. Upon sensing of pathogen, antigen presenting cells secrete innate cytokines such as IL-12 and IFN-α. CTL functions are specified by both antigen recognition and innate cytokines yielding a …
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The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons
… the role of TNF in regulating microglia effector functions to gauge the potential detrimental effects of anti-TNF therapies on the microglia functional response. I found that microglia from TNF-null mice produced reduced protein levels of cytokines and chemokines in response to LPS …
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Exploring the Role of PKD Enzymes in the Innate and Adaptive cells of the Mammalian Immune System
… expression and their role in the development and effector functions of myeloid cells. Thirdly, the requirement for PKD2 in the homeostasis of T lymphocytes within the small intestine was explored. The final objective was to determine if the development of regulatory T cells (Tregs) and if their …
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The Role of IkZF Factors in Mediating TH1/TFH Development and Flexibility
… nature (i.e having shared gene profiles and effector functions) not only demonstrate the efficiency of our immune system but also how such flexibility could have unintended consequences during adverse events such as autoimmunity. An important mediator of such flexibility is cytokines. …
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