Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 80 for “"Effector Function"”.
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The role of Hedgehog signalling in T cell effector function
CD8+ and CD4+ T cells are critical effector cells of the immune system. CD8+ T cells specifically recognise and kill virally-infected and malignant cells. Mature naïve CD4+ T cells can polarise in the periphery into various lineages that orchestrate immune programmes in response to a variety of …
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The effects of ES-62 on DC maturation and effector function
… cytokines that have important immuneregulatory functions. To date, more than 6 different DC subtypes have been identified that arise from at least two different cell lineages. These subtypes are not only phenotypically distinct but they are also thought to perform different functions and be …
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Streptococcus pneumoniae mediated negative regulation of CD8+ T cell effector function
Infection with influenza A virus (IAV) can lead to increased susceptibility to subsequent bacterial infection, often with Streptococcus pneumoniae (Spn). Clinical and experimental data indicate increased disease severity when a coinfecting agent is present during IAV infection, indicating the need …
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Autogramin-2, a synthetic sterol, inhibits T cell adhesion and effector function
… it stabilises immune synapses, thus supporting effector T cell function. Recent publications suggest that increasing plasma membrane cholesterol content boosts anti-viral and anti-cancer immunity in T cells. Inhibition of cholesterol transport from the plasma membrane to the endoplasmic …
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Antioxidant PRDX1 limits CD8+ T cell effector function in the tumour microenvironment
… at restoring or enhancing endogenous CD8+ T cell function has had profound clinical success and exemplifies the anti-tumour potential of T cell immunity. Nevertheless, therapeutic efficacy is confined to a subset of patients and responsive cancer types, highlighting additional and poorly defined …
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Uncovering New Mechanisms of Type III CRISPR-Cas System Inhibition and Effector Function
… III CRISPR system which contains a multi-protein effector complex that functions together with its crRNA in target binding and cleavage. During type III CRISPR-Cas immunity in prokaryotes, RNA-guided recognition of viral (phage) transcripts stimulates the Cas10 complex to convert ATP into cyclic …
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Inflammasome-Independent Interleukin-1 Beta Drives CD4 T Cell Effector Function and Autoimmune Inflammation
… (IL)-1 receptor family is required for effector cytokine production by memory CD4 T cells. Mechanistically, IL-1R signaling provides post-transcriptional stability to T cell cytokine transcripts thereby enabling productive secretion of these cytokines. Second, I discovered that DC-T cell …
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Regulation and Effector Function of TH1 and TH2 Cells in Immunity to Bordetella Pertussis
The evaluation of vaccines for human use requires reliable models of infection, that are predictive of protective efficacy. Traditionally whole cell pertussis vaccines (Pw) have been controlled using the Kendrick test, which measures protection following intracerebral challenge with Bordetella …
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T cell receptor- and calcium-induced Gli signalling in CD8+ T cell effector function
CD8+ cytotoxic T lymphocytes (CTLs) are potent effector cells of the immune system, capable of directly lysing neoplastic and infected cells. The Hedgehog (Hh) signalling pathway - a critical regulator of embryonic development and adult tissue maintenance - is induced in CTLs following TCR …
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RNA binding proteins ZFP36 and ZFP36L1 limit CD8+ T cell differentiation and effector function
… the ZFP36 proteins in the differentiation and effector functions of CD8+ T cells remain to be explored. My project utilized mice featuring the OT-1 transgenic T cell receptor to produce cytotoxic T lymphocytes (CTLs) and memory-like CD8+ T cells in vitro. I made use of knockout mouse models …
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MHC Class I Tyrosine Phosphorylation Site Y320 Augments CD8+ T Cell Priming, Effector Function, and Memory Response
… may play a role in determining the fate and function of CD8<sup>+</sup> T cells and suggest a novel strategy for improving DC-based cancer immunotherapies.</p>
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Regulation of Human Cytotoxic T Lymphocyte Functions by IL-12
… against intracellular pathogens by secreting effector cytokines and directly killing infected cells. Upon sensing of pathogen, antigen presenting cells secrete innate cytokines such as IL-12 and IFN-α. CTL functions are specified by both antigen recognition and innate cytokines yielding a …
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A License to Kill: Understanding Natural Killer Cell Licensing to Fight Cancer
… an essential developmental process for NK cell effector function, that renders some NK cells “licensed” and others “unlicensed” (with heightened or lowered effector function potential, respectively) against tumor and targets lacking self-molecules. However, the underlying mechanisms responsible …
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Fc Gamma Receptors Facilitate Antigenic Modulation of LILRB4 and Function as Predictive Biomarkers in Acute Monocytic Leukemia
… bridging and has been shown to reduce the effector function of anti-CD20 antibodies targeting B cell malignancies.</p> <p>Through this Fc-mediated mechanism, the anti-LILRB4 mAb and others bind their target receptor, inducing internalization of the antigen complex. In the case of …
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Exploring the Role of PKD Enzymes in the Innate and Adaptive cells of the Mammalian Immune System
… peripheral CD4+ and CD8+ cytotoxic T lymphocyte function in vivo. PKD enzymes are known to be involved in adaptive immunity but it is not known if this is true for PKD in cells of the myeloid lineage, including dendritic cells (DCs) and macrophages or in myeloid malignancies such as chronic …
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Pre-programmed regulatory networks and poised chromatin potentiate lineage-specific differentiation of CD4+ T cells
… of chromatin control the basis for cellular function and identity remains an open question. Here, analysis of regions of accessible chromatin, which are identified globally across T cell subtypes, demonstrates that the chromatin of naïve CD4 T cells is poised towards the acquisition of …
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The scaffold protein POSH regulates T lymphocyte function
… is required for optimal JNK activation and effector function in both CD4+ and CD8+ T cells. Additionally, this work shows that POSH is dispensable for JNK activation and positive and negative selection in developing thymocytes. Thus, POSH couples the TCR to JNK activation in a cell type and …
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The dynamics of anti-tumour responses generated by chimeric antigen receptor-modified immune effector cells
… tumours. Understanding the biology of CART cell effector function may explain treatment failure, and lead to more effective cell therapy products. Population-based assays such as flow cytometry give a snapshot of these complex cellular systems, but do not allow one to study the fate of individual …
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CD8⁺ T Cell Response to Influenza Virus
… the mediastinal lymph node, proliferate and gain effector function, then migrate to the lungs, where they selectively destroy infected cells. The CD8+ effector population pool undergoes a phase of contraction, when most effector cells die. Those that survive become memory T cells, protecting the …
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Epithelial Retinoic Acid Receptor Beta Regulates Serum Amyloid A Expression and Vitamin A-Dependent Intestinal Immunity
… the known role of SAAs in regulating Th17 cell effector function, epithelial RARβ promoted IL-17 production by intestinal Th17 cells. More broadly, epithelial RARβ was required for the development of key vitamin A-dependent adaptive immune responses, including CD4+ T cell homing to the intestine …
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