Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Editing domain"”.
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PTEN-5-HT2CR Complex: An Ideal Target for Developing Treatment to Restore the Functioning of 5-HT2CR; An Attempt to Minimize the Development of Antimicrobial Resistance
… antibiotic activity by trapping tRNALeu in the editing domain. Inspired by AN2690 and other benzoxaborole derivatives, we designed (S)-3-Aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol to block the editing domain. A rationally stable analogue of Leu-AMP intermediate was designed …
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Editing by leucyl-trna synthetase: Discrimination of norvaline and isoleucine
… amino acids. In such cases, AARSs have developed editing mechanisms to circumvent the issue of misaminoacylation. Leucyl-tRNA synthetase (LeuRS), for instance selectively edits misactivated and mischarged non-leucine amino acids via pre-transfer editing of misactivated adenylates in the synthetic …
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The Development and Application of Methods to Study the Evolution of Specificity, Allostery, and RNA -Protein Interactions in Translation
… I AARS family consists only of the catalytic domain while the anticodon binding domain and the editing domain were later additions that evolved as specificity emerged in the AARSs. In the second step of translation, the elongation factor Tu (EF-Tu) binds to all the standard aminoacyl-transfer …
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Characterization of leucyl-TRNA synthetase from homo sapiens and escherichia coli in aminoacylation, amino acid editing and interdomain interactions
… to maintain fidelity during protein synthesis, editing mechanisms ensure that tRNAs are accurately charged. Leucyl-tRNA synthetase (LeuRS) has an editing active site that resides in a discrete domain called the connective polypeptide 1 domain (CP1). Post-transfer editing involves the …
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On the fidelity of translation
… mismatched products are cleared by hydrolytic editing mechanisms, which are essential to maintain the fidelity of translation. These editing mechanisms include pre-transfer editing that targets misactivated adenylate, and post-transfer editing that hydrolyzes misacylated tRNA. We identified aaRSs …
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Elaboration of 4′-Phosphopantetheine Adenylyltransferase inhibitors and Benzoxaboroles as antimalarial agents
… rationalization of the binding mode in the editing domain of the P. falciparum LeucyltRNA (LeuRS) showed that these compounds have favourable interactions similar to previously reported related compounds. Lastly, the investigation of physicochemical properties determined both computationally …