Global ETD Search

Examining the effect of anti-tumor lipid drugs on pH homeostasis and membrane structure in Saccharomyces cerevisiae

Czyz, Ola Aleksandra JoannaGraduate Studies2013

The lysophosphatidylcholine analogue, edelfosine is a potent anti-tumor lipid drug that is known to target cellular membranes. The underlying mechanisms leading to cell death remain largely controversial, although previous results obtained using yeast, have indicated that edelfosine associates with …

calgary Repository record for Examining the effect of anti-tumor lipid drugs on pH homeostasis and membrane structure in Saccharomyces cerevisiae (opens in a new tab)

Role of diacylglycerol in the cellular response to lysophosphatidylcholine analogues

Ganesan, SuriakarthigaScience2019

… with the lysophosphatidylcholine analogue edelfosine. We hypothesized that by manipulating levels of PA and DAG, cells confer resistance to edelfosine, possibly due to mislocalized PA and DAG which prevent cellular response to edelfosine. Experiment where PA and DAG levels were manipulated …

calgary Repository record for Role of diacylglycerol in the cellular response to lysophosphatidylcholine analogues (opens in a new tab)

Characterisation of the pre-invasion glycophosphatidylinositol-anchored surface proteins of Plasmodium falciparum merozoites

University of Pretoria2017

… to be harvested. Four compounds (vanadate, edelfosine, dioctyl sodium sulfosuccinate (DSS), and gentamicin) suspected to interfere with GPIanchored cleavage or processes were screened on intraerythrocytic stages and merozoites. Antimalarial and anti-invasive properties of these compounds …

pretoria Repository record for Characterisation of the pre-invasion glycophosphatidylinositol-anchored surface proteins of Plasmodium falciparum merozoites (opens in a new tab)

TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes

Wohlfahrt, Deborah2019

… is necessary as their inhibition by LY294002 and edelfosine, respectively, abolished the rises. The rises do not involve store release via IP3 receptors and SOCE, suggesting that either PIP2 hydrolysis and/or DAG generation lead to channel activation. Both, disruption of F-actin polymerization and …

aus-cath Repository record for TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes (opens in a new tab)

TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes

Wohlfahrt, Deborah2019

… is necessary as their inhibition by LY294002 and edelfosine, respectively, abolished the rises. The rises do not involve store release via IP3 receptors and SOCE, suggesting that either PIP2 hydrolysis and/or DAG generation lead to channel activation. Both, disruption of F-actin polymerization and …

anu Repository record for TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes (opens in a new tab)

Eficacia del análogo alquil-lisofosfolípido edelfosina en el tratamiento de la leishmaniosis, generación de resistencia y su utilidad potencial en terapia combinada

Varela Miranda, Rubén Eduardo2013

salamanca Repository record for Eficacia del análogo alquil-lisofosfolípido edelfosina en el tratamiento de la leishmaniosis, generación de resistencia y su utilidad potencial en terapia combinada (opens in a new tab)