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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 7 of 7 for “"Ectonucleotidase"”.

  1. The human ectoenzyme CD73 (5’ Ectonucleotidase): analysis of its role in physiology and pathology by means of specific monoclonal antibodies.

    Malavasi, Fabio, Mariani, ValentinaUniversità degli Studi di Torino2018

    unito Repository record

  2. ADP regulation of insulin secretion and beta-cell apoptosis

    Tan, ChanyuanDepartment of Cardiology, Clinical sciences, Lund University2012

    … in vascular smooth muscle cells (VSMCs) through ectonucleotidase or ATP release under the effect of high glucose. The expression of the ADP receptors P2Y1 and P2Y13 were shown in both mouse pancreatic islets and isolated β-cells using real-time PCR quantification. Insulin and glucagon secretion …

    lund Repository record

  3. Integrated modulation of sympathetic tone in the microcirculation by oxygen, adenosine, and nitric oxide

    Sauls, Bryan Auston2019

    … constriction. In the presence of the 5'-ectonucleotidase inhibitor alpha,beta-methyleneadenosine 5'-diphosphate (4.5 x 10-5 M), the enhancing effects of L-NMMA and the high-O2 superfusate on sympathetic constriction were preserved. None of these treatments had an effect on vascular smooth …

    wvu Repository record

  4. Regulation of blood platelet function by the AGC family of protein kinases

    Aburima, Ahmed A.Hull York Medical School, the University of Hull and the University of York2010

    … (NO); (2) prostacyclin (PGI₂ ); and (3) the ectonucleotidase CD39. NO and PGI2 stimulate signalling cascades that result in the activation of the AGC family of Ser/Thr protein kinases (PKA, PKG and PKC). Once activated these kinase blunt platelet function through the phosphorylation of …

    hull Repository record

  5. Immunotolerance regeneration by T regulatory cells in autologous haematopoietic stem cell transplantation for multiple sclerosis

    Hendrawan, KevinUNSW, Sydney2021

    … T regulatory cells (Tregs). Tregs expressing the ectonucleotidase enzyme CD39 exert immunoregulatory function by suppressing T helper (Th)17-related immune responses, which has been significantly associated with MS pathogenesis. However, this immunoregulatory function was reported to be decreased …

    unsw Repository record

  6. Neuroepithelial Signalling in the Colon

    Meng, MichelleUniversity of Cambridge2024

    … response to GSK1016790A in the presence of ectonucleotidase inhibition and the release of ATP and glutamate in the supernatant of colonic tissue treated with GSK1016790A. Furthermore, the co-culture of DRG sensory neurons with mucosal cells derived from the colon enhanced the proportion of …

    cambridge Repository record

  7. Novel Modulators of CD39 and CD73

    Vadlamani, VenkatUniversity of Cambridge2024

    CD39 and CD73 are crucial in purinergic signalling, converting triphosphate and diphosphate nucleotides such as ATP and ADP into AMP, which CD73 further degrades into adenosine. CD39 and CD73 dysregulation is linked to various diseases. In cancer, their upregulation is associated with immune …

    cambridge Repository record