Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Ectodomain shedding"”.
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Characterisation of the ectodomain shedding of angiotensin-converting enzyme
Bibliography: leaves 240-266.
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The characterisation of the ectodomain shedding of the low density lipoprotein receptor
Includes abstract. Includes bibliographical references (leaves 142-155).
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Interrogating regulated intramembrane proteolysis of IGF-1R, and its role in cell migration
… (RIP). This proteolytic pathway begins with ectodomain shedding, mediated by sheddases, which produces a soluble fragment in the extracellular space. Following ectodomain shedding, a membrane anchored C-terminal fragment (CTF) is produced which is then cleaved by gamma-secretase at the …
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Role of Type III TGF-β Receptor Shedding in Regulating Tumorigenesis
… to initiate signaling. TβRIII also undergoes ectodomain shedding to release a soluble form (sTβRIII) that can bind ligand, sequestering it away from cell surface receptors. We have previously identified a TβRIII extracellular mutant that has enhanced ectodomain shedding (“super shedding (SS)” …
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Identification and characterization of innate immune receptor substrates of γ-secretase enzyme complex
… of clathrin-dependent receptor endocytosis, both ectodomain shedding and γ-secretase-mediated cleavage of IL-1R1 were observed post-internalization. In contrast, TNFR-1 underwent ectodomain shedding at the cell surface followed by endosomal γ-secretase-mediated cleavage. Furthermore, immortalised …
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Characterisation of the structural motifs Involved in the cleavage and secretion of human angiotensin-converting enzyme
… ACE and it has been proposed that regions in its ectodomain direct its shedding. Discrete secondary structures on the surface of the distal ectodomain of tACE were replaced with their N-domain counterparts to determine their role in the ectodomain shedding of ACE. None of the regions investigated …
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Characterisation of the molecular mechanisms of EGFR signal transactivation in human cancer
… family are selectively recruited for specific ectodomain shedding of proAR and/or proHB-EGF and subsequent EGFR activation. Furthermore, biological responses induced by LPA or S1P such as migration in breast cancer and HNSCC cells, depend on ADAM17 and proHB-EGF/proAR function, respectively, …
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A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
… PKC-activation with phorbol ester induced ectodomain shedding of sTNFR1 from sTNFR1-tm-Y-egfp. In addition to cell lines, the soluble TNF receptor construct sTNFR1-tm-Y was also successfully expressed in normal murine hematopoietic progenitor cells. During granulopoietic differentiation …
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CD200: A Novel Therapeutic Target for Chronic Lymphocytic Leukemia
… cells showed that sCD200 was produced following ectodomain shedding by ADAM proteases and MMPs. Results from studies reported in this thesis support the hypothesis that CD200 plays a major role in CLL biology, and suggests it may represent a novel therapeutic target for CLL.
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Mechanical Strain-Mediated Syndecan Regulation and Its Effects on Adhesion of Vascular Smooth Muscle Cells
… also modulated syndecan-4 protein expression and ectodomain shedding, as measured by Western immunoblotting, and this effect was found, through selective inhibition, to be at least in part dependent on mitogen-activated protein (MAP) kinase signaling. In particular, intact extracellular …
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Functional analysis of murine CD43 shedding : a role for the CD43 cytoplasmic tail in nuclear signalling
… plasma. The biological significance of CD43 shedding however remains enigmatic. To study the functional significance of CD43 shedding, we initiated our study by investigating whether CD43 shedding also occurs in the murine system and confirmed using flow cytometry, Western blot and ELISA …
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CNS endothelium expression of ADAM-17 and its role in multiple sclerosis pathogenesis.
… between ADAM-17 activity and fractalkine shedding, small interfering (si) RNA silencing of ADAM-17 was performed in the hCMEC/D3 endothelial cells line. This work revealed that despite knockdown of ADAM-17, fractalkine shedding was not significantly reduced. Again this suggests other …
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B cell ADAM10 Activity is Increased by Kainate Receptor Activation: Potential Role of this Pathway in Th2 Immunity and Cancer
… indicate that the enzyme responsible for CD23 ectodomain shedding is a hydroxamate-sensitive metalloproteinase. Through collaboration with the Blobel group, we analyzed various ADAM KO mouse embryonic fibroblasts (MEFs) and found no involvement of ADAMs 8,9,12,15,17,19, and 33 in CD23 shedding, …