Global ETD Search
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Showing 1 to 15 of 15 for “"Ebola virus disease"”.
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Mathematical Models of Ebola Virus Disease and Vaccine Preventable Diseases
… dynamics and control interventions of infectious diseases such as Ebola virus disease and vaccine preventable diseases.</p> <p>Many models in studies of Ebola transmission are based on the model by Legrand et al. (2007). However, there are potential issues with the Legrand model. First, the model …
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Economic impact of Ebola virus disease in Western African countries.
The Ebola outbreak in Western Africa from 2014 to 2016 infected 28600 people and claimed lives of 11325 people. It is the worst and the longest Ebola outbreak since the first recorded Ebola outbreak in 1976. The World bank estimated the cost of this outbreak is approximately $4 billion. In this …
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Metagenomic investigation of co-infections of Ebola virus disease and Lassa fever patients
… extremely promising method for broad, unbiased disease profiling of patients for disease surveillance and diagnosis. Here, we use two popular metagenomics tools in union, k-mer-based Kraken with reads and BLAST- and LCAbased MEGAN with assembled contiguous sequence. We analyze sequence from 463 …
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Characterization of Ebola virus VP35-dsRNA binding for drug development against Ebola virus disease.
The Ebola virus (EBOV) VP35 protein plays an important role in the inhibition of the initial innate immune responses to EBOV infection leading to Ebola virus disease development. In fact, VP35 interaction with the RIG-I like receptors (RLR) cascade components inhibits the interferon (IFN) …
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The Ebola Virus and West Africa: Medical and Sociocultural Aspects
… of the socio-cultural factors on communicable disease, especially Ebola. We have failed at managing Ebola outbreaks in Africa. Most of the preparatory and intensive training of health personnel attending to the needs of those societies where culture is at the center of life have given only lip …
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Modeling Emerging Infectious Diseases for Public Health Decision Support
Emerging infectious diseases (EID) pose a serious threat to global public health. Computational epidemiology is a nascent subfield of public health that can provide insight into an outbreak in advance of traditional methodologies. Research in this dissertation will use fuse nontraditional, publicly …
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Ebola in West Africa : The Unintended consequences of the response to the western African Ebola crisis 2014-2016
Since 2014, an outbreak of Ebola virus disease has taken place in the western African countries of Sierra Leone, Liberia, and Guinea. With its high mortality rate and rapid incidence rate, the virus has crippled the communities of these countries and their governments. To amplify matters these …
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Ebola Response: A Summary of Field Work Project
<p>While epidemics and disease outbreaks are not uncommon world wide, the most recent outbreak of Ebola Virus Disease (EVD) has been the largest outbreak of the disease and the most wide spread in history. The outbreak has caused international concern and was declared a public health emergency of …
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A systems analysis of preventative measures and attributes of a resilient enterprise
The Ebola Virus Disease (EVD) outbreak of 2014 had a considerable socioeconomic impact on the affected West African countries. The extractive sector plays a key role in these economies in providing employment opportunities, tax revenue and contributions to gross domestic product (GDP) with some …
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Communicable Disease Control in New South Wales and globally
Effective communicable disease control calls for a wide range of core public health competencies. In fulfilling the requirements of the Masters of Philosophy in Applied Epidemiology (MAE), I conducted projects in my placement at Health Protection New South Wales (NSW) between March 2014 and October …
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Communicable Disease Control in New South Wales and globally
Effective communicable disease control calls for a wide range of core public health competencies. In fulfilling the requirements of the Masters of Philosophy in Applied Epidemiology (MAE), I conducted projects in my placement at Health Protection New South Wales (NSW) between March 2014 and October …
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Antibody-based diagnostics and therapeutics for Zaire ebolavirus and Burkholderia pseudomallei
Zaire ebolavirus (EBOV) and Burkholderia pseudomallei are the causative agents of Ebola virus disease (EVD) and melioidosis, respectively. Early diagnosis is critical for halting the spread of the disease or providing treatment of the disease. Current diagnosis for EBOV includes polymerase chain …
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Activation of the TLR4 Signalling Complex by the Ebola Virus Glycoprotein
Infection by the Ebola virus, a member of the Filoviridae family of negative sense unsegmented RNA viruses, leads to acute viral haemorrhagic fever with a fatality rate of greater than 50 % and is currently incurable. As such, understanding the biochemical mechanisms and molecular interactions …