Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"Ebola Virus"”.
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Characterization of Ebola virus VP35-dsRNA binding for drug development against Ebola virus disease.
The Ebola virus (EBOV) VP35 protein plays an important role in the inhibition of the initial innate immune responses to EBOV infection leading to Ebola virus disease development. In fact, VP35 interaction with the RIG-I like receptors (RLR) cascade components inhibits the interferon (IFN) …
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Proviral Roles of Ebola virus VP35 Ubiquitination
Ebola virus’ structural protein VP35 is polyfunctional and plays vital roles in Ebola’s life cycle from antagonizing the host’s type I interferon pathway to acting as the polymerase co-factor. The mechanisms that regulate which function any given VP35 molecule engages remains unknown. Previously, …
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Protein dissection of the Ebola virus glycoprotein
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Aerosolization of Ebola Virus Surrogates in Wastewater Systems
Recent studies have shown that Ebola virus can persist in wastewater, and the potential for the virus to be aerosolized and pose a risk of inhalation exposure has not been evaluated. We considered this risk for three wastewater systems: toilets, a lab-scale model of an aeration basin, and a …
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Enhancement Of Ebola Virus Infection By Seminal Amyloid Fibrils
The 2014-2016 West Africa epidemic was the worst Ebola virus outbreak on record, with the infected numbering over 28,000 and the dead more than 11,000. Among those who survived the disease, Ebola virus was found to persist in numerous anatomical locations and be shed in semen. During the West …
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Mathematical Models of Ebola Virus Disease and Vaccine Preventable Diseases
… interventions of infectious diseases such as Ebola virus disease and vaccine preventable diseases.</p> <p>Many models in studies of Ebola transmission are based on the model by Legrand et al. (2007). However, there are potential issues with the Legrand model. First, the model was originally …
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The Ebola Virus and West Africa: Medical and Sociocultural Aspects
… factors on communicable disease, especially Ebola. We have failed at managing Ebola outbreaks in Africa. Most of the preparatory and intensive training of health personnel attending to the needs of those societies where culture is at the center of life have given only lip service to the …
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Economic impact of Ebola virus disease in Western African countries.
The Ebola outbreak in Western Africa from 2014 to 2016 infected 28600 people and claimed lives of 11325 people. It is the worst and the longest Ebola outbreak since the first recorded Ebola outbreak in 1976. The World bank estimated the cost of this outbreak is approximately $4 billion. In this …
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Activation of the TLR4 Signalling Complex by the Ebola Virus Glycoprotein
Infection by the Ebola virus, a member of the Filoviridae family of negative sense unsegmented RNA viruses, leads to acute viral haemorrhagic fever with a fatality rate of greater than 50 % and is currently incurable. As such, understanding the biochemical mechanisms and molecular interactions …
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Metagenomic investigation of co-infections of Ebola virus disease and Lassa fever patients
… from Sierra Leone before and during the 2014 Ebola virus outbreak. We find that co-infection with malaria is correlated with increased survival of Ebola virus patients, from 18% survival rate to 53%. We also explore the utility of and emphasize the need for both positive and negative controls …
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Description of interactions of Ebola virus with a putative reservoir species using next-generation sequencing
Ebola virus (EBOV) causes a severe, often fatal disease in humans and nonhuman primates. Recently, EBOV has caused two very large outbreaks, one of which is ongoing in the Democratic Republic of the Congo. Bats are the likely reservoir of EBOV, but little is known of their relationship with the …
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Structural and functional studies of human ADAM 12 in myoblast fusion and Ebola virus VP40 in assembly
… vitro</i>.<br></br><br></br>Part II:<br></br>The Ebola virus matrix protein, VP40, is targeted to the plasma membrane where it is thought to induce assembly and budding of virions. Ebola virus VP40 is a monomer in solution consisting of two domains. Cellular localisation studies ofdifferent VP40 …
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Adapting the Standard SIR Disease Model in Order to Track and Predict the Spreading of the EBOLA Virus Using Twitter Data
… was demonstrated during the West African Ebola outbreak of 2014. Using a meme based n-gram semantic usage model to search the Twitter database for indications of illness, flight and death from the spread of Ebola in Africa, principally from Guinea, Sierra Leone and Liberia. Memes of …
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THE CORNERSTONE OF A CONSPIRACY: THE ROLE OF HUMAN-WILDLIFE PERCEPTIONS IN THE MASS DISBELIEF IN THE EBOLA VIRUS, NORTHERN SIERRA LEONE
… analysis of the digital media output around the Ebola epidemic I explore how the role of centuries of external forces in Sierra Leone, as well as the international attitudes of disgust towards Sierra Leonean culture, shaped the response to the 2014 Ebola outbreak. I began this thesis hoping to …
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Millennium Bugs and Weapons of Mass Fear: Dialogs Between Science and Popular Culture in the 1990's
… For example, the increase in media attention to Ebola virus actually preceded the actual 1995 outbreak of this disease in Zaire, which occurred a full 19 years after the most recent previous outbreak. Mass media, including the news, do not simply reflect reality, but also create it through the …
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Diseased Identities: How the American Media Constructed the 2014 Ebola Outbreak in West Africa
… in the American media coverage of the 2014 Ebola outbreak and the differing policy solutions they sometimes elicit. I hypothesize that there is a connection between identity construction and policy solutions that can be explored along two major trajectories. First, I find sources that prefer …
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Modeling Emerging Infectious Diseases for Public Health Decision Support
… Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), and Ebola virus disease (EVD) outbreaks. This effort will provide quantitative, evidenced-based guidance for policymakers and public health responders to augment public health operations.
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Structure-based approaches applied to the study of pharmaceutical relevant targets
… of HIV-1, Monoamine oxidase B and VP35 of Ebola virus. The last chapter is dedicated to the validation of covalent docking performed with Autodock.
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Ebola in West Africa : The Unintended consequences of the response to the western African Ebola crisis 2014-2016
Since 2014, an outbreak of Ebola virus disease has taken place in the western African countries of Sierra Leone, Liberia, and Guinea. With its high mortality rate and rapid incidence rate, the virus has crippled the communities of these countries and their governments. To amplify matters these …
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Ebola Response: A Summary of Field Work Project
… uncommon world wide, the most recent outbreak of Ebola Virus Disease (EVD) has been the largest outbreak of the disease and the most wide spread in history. The outbreak has caused international concern and was declared a public health emergency of international concern by the World Health …
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