Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"Ebola"”.
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Characterization of Ebola virus VP35-dsRNA binding for drug development against Ebola virus disease.
The Ebola virus (EBOV) VP35 protein plays an important role in the inhibition of the initial innate immune responses to EBOV infection leading to Ebola virus disease development. In fact, VP35 interaction with the RIG-I like receptors (RLR) cascade components inhibits the interferon (IFN) …
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Ebola in West Africa : The Unintended consequences of the response to the western African Ebola crisis 2014-2016
Since 2014, an outbreak of Ebola virus disease has taken place in the western African countries of Sierra Leone, Liberia, and Guinea. With its high mortality rate and rapid incidence rate, the virus has crippled the communities of these countries and their governments. To amplify matters these …
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Proviral Roles of Ebola virus VP35 Ubiquitination
Ebola virus’ structural protein VP35 is polyfunctional and plays vital roles in Ebola’s life cycle from antagonizing the host’s type I interferon pathway to acting as the polymerase co-factor. The mechanisms that regulate which function any given VP35 molecule engages remains unknown. Previously, …
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Protein dissection of the Ebola virus glycoprotein
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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The Ebola Experience: Media Lessons For Nurse Leaders
… when two nurses became infected with the Ebola virus, and another nurse who cared for Ebola patients defied two gubernatorial quarantine orders. Nurses have traditionally received little media attention, and the nursing profession was largely unprepared for the intense media scrutiny which …
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Ebola Response: A Summary of Field Work Project
… uncommon world wide, the most recent outbreak of Ebola Virus Disease (EVD) has been the largest outbreak of the disease and the most wide spread in history. The outbreak has caused international concern and was declared a public health emergency of international concern by the World Health …
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Aerosolization of Ebola Virus Surrogates in Wastewater Systems
Recent studies have shown that Ebola virus can persist in wastewater, and the potential for the virus to be aerosolized and pose a risk of inhalation exposure has not been evaluated. We considered this risk for three wastewater systems: toilets, a lab-scale model of an aeration basin, and a …
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Enhancement Of Ebola Virus Infection By Seminal Amyloid Fibrils
The 2014-2016 West Africa epidemic was the worst Ebola virus outbreak on record, with the infected numbering over 28,000 and the dead more than 11,000. Among those who survived the disease, Ebola virus was found to persist in numerous anatomical locations and be shed in semen. During the West …
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2014 Ebola newspaper coverage : through the lens of Orientalism
… States (U.S.) newspaper coverage of the 2014 Ebola outbreak and its representation of West Africa in relation to the West. The study sought to determine whether the coverage reflected the theory of Orientalism, as defined by Palestinian-American philosopher Edward Said. Orientalism refers to …
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Mathematical Models of Ebola Virus Disease and Vaccine Preventable Diseases
… interventions of infectious diseases such as Ebola virus disease and vaccine preventable diseases.</p> <p>Many models in studies of Ebola transmission are based on the model by Legrand et al. (2007). However, there are potential issues with the Legrand model. First, the model was originally …
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The Ebola Virus and West Africa: Medical and Sociocultural Aspects
… factors on communicable disease, especially Ebola. We have failed at managing Ebola outbreaks in Africa. Most of the preparatory and intensive training of health personnel attending to the needs of those societies where culture is at the center of life have given only lip service to the …
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Economic impact of Ebola virus disease in Western African countries.
The Ebola outbreak in Western Africa from 2014 to 2016 infected 28600 people and claimed lives of 11325 people. It is the worst and the longest Ebola outbreak since the first recorded Ebola outbreak in 1976. The World bank estimated the cost of this outbreak is approximately $4 billion. In this …
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A multi-objective sequential stochastic assignment problem for Ebola entry screening
The 2014 Ebola outbreak in West Africa prompted a need to assess how deplaning passengers from West Africa should be managed. A 21-day quarantine requirement for deplaning passengers, based on their risk factors, was implemented at five international airports in the United States in late 2014. This …
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The ‘truth about Ebola’: Insecure epistemologies in post-outbreak Forest Guinea
… of sampling animals. While scarcely any case of Ebola had ever been reported in West Africa, the deadliest epidemic to date started in 2013 in the southeastern region of Guinea called ‘Forest Guinea’. Since then, ecologists and virologists from Africa, America and Europe have been conducting the …
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Activation of the TLR4 Signalling Complex by the Ebola Virus Glycoprotein
Infection by the Ebola virus, a member of the Filoviridae family of negative sense unsegmented RNA viruses, leads to acute viral haemorrhagic fever with a fatality rate of greater than 50 % and is currently incurable. As such, understanding the biochemical mechanisms and molecular interactions …
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Experiences of Nurses and Midwives during the Ebola Outbreak in Liberia, West Africa
<p>The 2014 – 2015 Ebola outbreak in the West African region resulted in many deaths and has been responsible for devastating health and socioeconomic upheaval. The decision of nurses and midwives whether or not to render care during outbreaks is vital for the containment of the disease. The …
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Metagenomic investigation of co-infections of Ebola virus disease and Lassa fever patients
… from Sierra Leone before and during the 2014 Ebola virus outbreak. We find that co-infection with malaria is correlated with increased survival of Ebola virus patients, from 18% survival rate to 53%. We also explore the utility of and emphasize the need for both positive and negative controls …
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Diseased Identities: How the American Media Constructed the 2014 Ebola Outbreak in West Africa
… in the American media coverage of the 2014 Ebola outbreak and the differing policy solutions they sometimes elicit. I hypothesize that there is a connection between identity construction and policy solutions that can be explored along two major trajectories. First, I find sources that prefer …
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Description of interactions of Ebola virus with a putative reservoir species using next-generation sequencing
Ebola virus (EBOV) causes a severe, often fatal disease in humans and nonhuman primates. Recently, EBOV has caused two very large outbreaks, one of which is ongoing in the Democratic Republic of the Congo. Bats are the likely reservoir of EBOV, but little is known of their relationship with the …
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The Local Governance of the 2014 Ebola Epidemic: A Comparative Case Study of Liberia and Sierra Leone
… in the response and outcomes of the 2014 Ebola epidemic. Many challenges made aid less effective such as misinformation, rumors, stigma, and logistical difficulties that lowered the demand for aid resources. These market inefficiencies were the demand-side barriers that were prolonging the …
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