Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Eat-me signal"”.
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Discovery of Anti-CD47 Peptides for Cancer Immunotherapy and CD47-mimicking Peptides That Inhibit Phagocytic Clearance of Nanoparticles
In the last few decades cancer immunotherapy has emerged as a standard pillar of cancer treatment. Immune checkpoint inhibitors that are currently available target the adaptive immune system, generating T-cell antitumor responses. As critical innate immune cells, macrophages play important roles in …
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An unbiased proteomic approach to identifying cell surface markers in neutrophils
Introduction: Efferocytosis refers to the engulfment of dead cells by phagocytes such as neutrophils and macrophages and culminates in the beneficial removal of inflammatory cargo and auto-reactive material. While many of the mechanisms involved in efferocytosis have been described, the critically …
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Phosphatidylserine-Based Nanoparticles For Tolerance Induction Towards Therapeutic Proteins
… negatively charged phospholipid in the cell membrane. Despite comprising 12% of total phospholipid and being restricted primarily in the inner leaflet of the membrane bilayer, the consequences of PS externalization to the outer leaflet is biologically significant, especially in hemostasis and …
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The role of signal regulatory protein alpha in regulating macrophage subset activity in homeostasis and inflammation
… spectrum characterised by the polar extremes of two subsets, pro-inflammatory M1s and regulatory M2s. Both subsets express signal regulatory protein alpha (SIRPα), receptor to CD47. Characterised as a “don’t eat me” signal, SIRPα-CD47 ligation negatively regulates Mφ phagocytic activity. …
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Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
… on the surface of islets to promote islet engraftment by controlling thrombotic/inflammatory reactions associated with an immediate blood-mediated inflammatory response (IBMIR). In chapter 3, syngeneic pancreatic islets are engineered with a novel form of TM (SA-TM) to maintain euglycemia by …
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Role of CD47 In Red Cell Apoptosis (Eryptosis)
CD47 is a 47-52 kDa membrane spanning glycoprotein, which has 5 known isoforms and is a member of the immunoglobulin superfamily (IgSF). It possesses a large extracellular N-terminal IgV like domain. CD47 acts as a ‘do not eat me’ signal and consequently as a marker of self. Moreover, CD47 is …
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Investigating the effects of TREM2, APOE and PILRα variants on microglial functions and neuronal loss
… nervous system (CNS). They utilise a host of signals, receptors, and processes to maintain homeostasis and to resolve exogenous and endogenous insults in the brain. Mounting evidence over recent years has highlighted the central role of microglia in neurodegenerative diseases, including …