Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Early stage cancer"”.
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Sensor technology for the Breast Examination Training Instrument
… of American women, diagnosed with breast cancer. If detected in its early stage, cancer can be treated successfully. Breast examination might be obtained through three procedures: breast self-examination (BSE), clinical breast examination (CBE) and mammography. Project BETI was developed …
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A surgical confocal microlaparoscope for real-time optical biopsies
… disk or a linear pinhole array can achieve nearly the same depth performance as a single pinhole aperture. The model was used to determine the optimal aperture spacing for the multi-pinhole apertures. The confocal microlaparoscope represents a new type of in vivo imaging device. With its …
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An Electrospray Solution to the Pulmonary Delivery Problem
… Cisplatin, a chemotherapeutic, was delivered to cancer cells in a controllled experiment and killed >90% the cancer cells targeted. Methylene blue, the basis of an early stage cancer diagnostic test, was delivered to pigs, in vivo, using the device. It is concluded that an electrospray device …
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Chemical and Biological Strategies for Improving the Sensitivity of SPIO-Enhanced MR Imaging
The prevalence of cancer has seen significant growth over the last three decades, with the American Cancer Society now reporting that one in every three Americans will be afflicted with some form of cancer in their lifetime. The debilitating effects of cancer permeate beyond obvious biological …
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Physical activity and advanced cancer : a grounded theory approach
Background: Cancer-related fatigue and loss of physical functioning are distressing symptoms which negatively impact the quality of life of people with advanced cancer. Physical activity has been shown to have positive effects on these symptoms in early stage cancer, but previous research has …
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Development of ZnO Nanotube Arrays for Chemical Sensing
… global warming, air pollution, and the rise in cancer rates. The common cause is the excessive use of fossil fuels. It has been widely recognized that net-zero emissions should be achieved before the year 2050. Hydrogen produced using renewable sources is a clean energy vector that could help …
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Urinary Volatile Organic Compounds (VOCs) in the Diagnosis of Urothelial Bladder Cancer
Bladder cancer is the seventh most common cancer in the UK (2011), fourth most common cancer in men and thirteenth most common in women. The total annual cost of bladder cancers in the UK was £55.39 million. The cost per patient was £8349 per year, including diagnosing, treating and following up, …
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Monitoring trace levels of ctDNA using integration of variant reads
In patients with early-stage cancer, ctDNA detection rates can be low due to the presence of few or no copies of any individual mutation in each sample. Sensitivity may be increased by collecting larger plasma volumes, but this is not feasible in practice. Although cancers typically have thousands …
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Exploring the adaptive immune response to Oncogene-Induced-Senescence
… adaptive immune reaction and why it fails when cancer develops remain unclear. In this work, I have studied the adaptive immune response to senescence using in vitro and in vivo models. I have used hydrodynamic tail vein (HDTV) delivery of NRASG12V-containing transposons in mice, to model …
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Electromagnetic tracking and steering for catheter navigation
… is virtual navigation of the lung for biopsy of early stage cancer nodules. Navigation to the peripheral regions of the lung is difficult due to physical dimensions of the bronchi and current methods have low successes rates for accurate diagnosis. Firstly, the potential use of DC magnetic fields …
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Hygiena Study: audit of women managed with Cone Biopsy at Groote Schuur Hospital from 1st April 2013 to 31st October 2015
INTRODUCTION: Cervical cancer is the second commonest cancer in South Africa and the commonest amongst Black females with a Lifetime Risk (LR) of 1:35. In South Africa the problem has been compounded by the HIV epidemic as well as a lack of resources and infrastructure to offer an adequate …
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Optical spectroscopy for biological and biomedical applications: potentially impacting future of healthcare with research, clinical translation and education
… or samples, which is insufficient to detect early-stage diseases and identify tissue structures with enough contrast. Optical spectroscopy and imaging can solve this insufficiency by providing molecular-sensitive tools for applications involving screening, diagnosis, monitoring vital signs, …
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A retrospective audit of young patients diagnosed with cervical cancer over ten years at Groote Schuur Hospital, Cape Town between 1 January 2003 and 31 December 2012, and their outcome at five-year follow-up compared to women in the prior decade
Background : Cervical cancer is the second commonest gynaecological cancer amongst women worldwide and the leading cause of cancer deaths in developing countries – contributing 83% of new cases and 85% of all deaths annually to the burden of this disease. Information and awareness of this illness …
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Socio-spatial inequalities in late-stage cancer diagnosis in Illinois: spatiotemporal trends and methodological challenges
… of social and spatial inequalities on late-stage diagnosis of colorectal and breast cancer, and it addresses several methodological challenges surrounding the use of ZIP codes as a study unit in analyzing late-stage cancer at diagnosis. Given that my dissertation follows the ‘three-paper’ …