Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Early detection of cancer"”.
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Novel Low Coherence Interferometric Tools for Early Detection of Cancer
<p>Cancer encompasses many diseases affecting all parts of the body, is characterized by rapid, abnormal cell growth, and is one of the most common causes of death worldwide. Certain cancers, including cervical and colorectal cancer, exhibit very slow growth and histological evidence on or close to …
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Next generation instrumentation for photonic crystal biosensors: a passage to early detection of cancer
… addresses the need for an affordable point-of-care diagnostic tool for early detection of cancer. We identified a biomarker detection approach done using photonic crystal enhanced fluorescence (PCEF) instrumentation as the best way to achieve this goal. We introduce a model for predicting …
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Proteomics for cancer biomarker discovery
Background: If we are to successfully treat cancer, we must understand the biologic underpinnings in conjunction with early diagnosis. Genome-wide expression studies have advanced the research of many cancers. Nevertheless, understanding which genes are expressed in a tumor is not equivalent to …
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Versatility of M13 bacteriophage in medicine : vaccine storage and cancer diagnostics
Two novel ways of engineering the filamentous bacteriophage, M13, for the prevention, diagnosis, and treatment of human disease are proposed. Both ways are founded on the unique structural properties of the M13 bacteriophage and the ability of its major and minor coat proteins, p3 and p8, to be …
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Reservoir-based devices for the monitoring and treatment of disease
Cancer mortality still remains high despite significant investments in diagnostics, drug development, and treatment. The systemic route is convenient both for routine monitoring and for drug administration. Local cancer biomarker concentrations, however, are more indicative of the state of solid …
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The mutational landscape of normal urothelium
… cells within an individual. The accumulation of these somatic mutations can ultimately result in oncogenic transformation. Cancer development is often a multi-step process, the earliest stages of which remain incompletely understood. Recent technological advances have enabled detection of …
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Autophagy and EVs in cancer cells. Effect of ATG8 knockdown on the biogenesis of CD81+ extracellular vesicles.
Dysregulation of both the autophagy pathway and the biogenesis of extracellular vesicles (EVs) in cells is involved in cancer development. Evidence is now emerging that these pathways may somehow be interlinked via ATG proteins. Further elucidation of the relationship between these pathways will …
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A Compressed Sensing Approach to Detect Immobilized Nanoparticles Using Superparamagnetic Relaxometry
… technology that leverages the unique properties of biologically targeted superparamagnetic iron oxide nanoparticles to detect cancer. The use of ultra-sensitive sensors enables SPMR to detect tumors ten times smaller than current imaging methods. Reconstructing the distribution of cancer-bound …
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Statistical aspects of elastic scattering spectroscopy with applications to cancer diagnosis
… sensitive to changes in the physical properties of human tissue, and thus able to detect early cancer and precancerous changes. This thesis focuses on the statistical issue on how to eliminate irrelevant variations in the high-dimensional ESS spectra and extract the most useful information to …
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Biomarker discovery using urinary metabolomics for noninvasive early cancer detection
"The development of new screening methods for the early detection of cancer remains one of the foremost challenges facing modern cancer research. The emergence of new analytical technologies and their application to 'omics'-based approaches has provided researchers with powerful new tools for …
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Investigation of the immunological differences between granulocytes from healthy donors and breast cancer patients, with respect to the cancer testis antigen, CTCFL
… express surface receptors for the recognition of general antigenic patterns found on pathogens. In addition PMN’s also act as a mediator for the antigen-specific adaptive immunity and T-cells function. However, an anti-tumoral role of the PMN’s was suggested over the recent years beside their …
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Multi-omic characterisation of Barrett’s oesophagus reveals a molecular continuum in the progression to oesophageal adenocarcinoma
… (BE) is the main risk factor for the development of oesophageal adenocarcinoma (OAC) yet only 0.4%/year of non-dysplastic (ND) BE cases progress to cancer (Bhat et al., 2011). In this thesis I present the first comprehensive, multi-omics study comparing indolent, non-progressors with those who …
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Effects Of Dna Methylation Pattern On The Chromatin Structure
… DNA methylation is associated with silencing of tumor suppressor genes and is observed in the onset of tumorigenesis. There is evidence suggesting that not all methylation events are relevant in chromatin compaction and the initiation of cancer. It seems that methylation at certain locations …
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Multi and Hyperspectral Imaging of Early Detection of Disease
… This thesis has evaluated the application of MSI/HSI to two disease applications: analysing nailfold capillaries to aid in the evaluation of systemic scleroderma, and enhancing cancer detection in the gastrointestinal tract during endoscopies. The nailfold capillaries are the smallest blood …
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Thermoacoustic Imaging and Spectroscopy for Enhanced Cancer Diagnostics
Early detection of cancer is paramount for improved patient survival. This dissertation presents work developing imaging techniques to improve cancer diagnostics and detection utilizing light and microwave induced thermoacoustic imaging. In the second chapter, the well-established pre-clinical …
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Ex vivo proton magnetic resonance spectroscopy (1HMRS) of normal, reactive and malignant canine lymph nodes: evaluation of the choline metabolite as a marker for malignancy
Advanced imaging of veterinary cancer patients has evolved in recent years and modalities once limited to human medicine have now been described for diagnostic purposes in veterinary medicine (positron emission tomography/computed tomography, single-photon emission computed tomography, whole body …
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Identification of exosomal proteins in primary human bronchial tracheal epithelial cell HBTE and the H358, THP1 and MCF7 cell lines
Background: Early detection of cancer is of paramount importance for successful treatment. Unfortunately, this is currently complex and time consuming. New sources of biomarkers are needed to improve. Exosomes are nano sized extracellular vesicles released by almost all cells have gained much …
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A Review and Comparison of Breast Cancer and Breast Cancer Screening in Costa Rica and Guatemala in the Context of the Historical Development and Healthcare Infrastructure of Each Country
BACKGROUND: Breast cancer is the most frequently diagnosed cancer in women worldwide. Costa Rica has rates of breast cancer and breast cancer survival comparable to those of highly developed nations and has had tremendous success in the prevention and treatment of the disease. Guatemala has made …
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Knowledge and Perception of Cervical Cancer and Screening Programs of Women Seeking Care at Monduli Hospital in Tanzania and St. Paul Hospital in Addis Ababa, Ethiopia
… women's knowledge and attitude towards cervical cancer demonstrated over 75% of respondents correctly identified early marriage and multiparty, other studies demonstrated a lack of knowledge about cervical cancer screening and HPV transmission among patients and nurses. Additionally, many women …
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Regionale Unterschiede der Inanspruchnahme von Präventionsleistungen in der ambulanten Versorgung
Das Ziel dieser Studie war es die regionalen Unterschiede der Inanspruchnahme sekundärpräventiver Leistungen in Deutschland auf Kreisebene zu analysieren. Hierbei sollte eine Lücke in der deutschen Forschung geschlossen werden, indem neben individuellen Faktoren auch ökologische Faktoren durch …
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