Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Early Life Stress"”.
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Behavioural, immunological, and neurobiological effects of early life stress in rats
Early life stress (ELS), primarily encompassing childhood neglect and abuse, is associated with many adverse psychiatric and physical health outcomes in later life. What remains unclear, however, is precisely how these links are mediated. Answering this question is challenging, partly because there …
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Novel insights into early life stress-induced dysfunction of the gut-brain axis
… bowel syndrome, has a major impact on quality of life. Given the increasing prevalence of irritable bowel syndrome over the past number of years, as well as a lack of effective treatments for disorders of visceral pain, new strategies need to be undertaken to develop successful interventions. The …
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Nucleus accumbens GABAA receptor-mediated inhibitory transmission: Relevance to early life stress and addiction
… in control mice I then employed a mouse model of early life stress (ELS) to investigate the impact of early-life adverse experiences on cocaine-induced behaviours and the putative role of NAcore GABAARs in this interaction. An established fragmented maternal care paradigm was implemented to …
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EARLY LIFE STRESS EXPOSURE AND HYPOTHALAMIC PITUITARY ADRENAL AXIS: FROM MECHANISMS TO PERIPHERAL BIOMARKERS OF VULNERABILITY
… quali ad esempio l’esposizione ad eventi stressanti nel corso della vita, siano in grado di aumentare il rischio di sviluppare disturbi psichiatrici stress correlati che si caratterizzano per differenti entità ed età di insorgenza a seconda del momento e della durata dell’esposizione. …
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LONG-LASTING MOLECULAR ALTERATIONS FOLLOWING EARLY LIFE STRESS IN RATS: ROLE OF GUT MICROBIOTA AND INFLAMMATION
It is well known that stress, especially when experienced early in life, affects the brain developmental trajectories leading to an enhanced vulnerability for several mental disorders later in life. The adverse outcomes depend on the timing of the stressful experiences, and in this contest, early …
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Exploring the utility of pupillometry as a biomarker for relationships between early life stress, emotion regulation, and cognition
While the negative effects of early life stress (ELS) are well-documented, non-invasive biomarkers that can be used to aid early detection of vulnerable groups and overcome some of the limitations of self-report tools are not readily available. Recently, pupillometry has been recognised as a novel, …
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Alterations of the Corticotropin Releasing Hormone Receptor System Following Early Life Stress and Ethanol Self-Administration in Rhesus Monkeys
Early life stress (ELS) alters brain and neuroendocrine development leading to a higher risk of alcohol abuse. Corticotropin-releasing hormone (CRH), a primary mediator of the stress response in the brain, plays a regulatory role in ethanol (EtOH) consumption. The goal of this thesis was to …
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Sex Differences and the Role of the Serotonin System in Early Life Stress-Induced Ethanol-Motivated Behaviors in Adulthood
… in males and fail to target the psychological distress underlying alcohol motivation in those assigned female at birth and individuals with adverse childhood experiences who are more apt to drink to relieve negative affective states. The dorsal raphe nucleus (DRN)-serotonin (5-HT) system has an …
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A Role for glutamate and Gaba in attention-deficit/hyperactivity disorder: a study of the spontaneously hypertensive rat
… using an in vitro superfusion technique. Since early life stress has been shown to increase the risk of developing ADHD, the present thesis also investigated how a model of early life stress (maternal separation) affects behavioural responses to novelty (behavioural assays), plasma …
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Novel insights into the role of the GABAB receptor in depression and anxiety
… have strongly implicated the GABAB receptor in stress-related psychiatric disorders, however, the precise contribution of the GABAB receptor in depression and anxiety disorders remains unknown. Emerging data suggest that the interaction between adverse environmental conditions, such as early …
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The effects of prenatal and early-postnatal ethanol exposure on rat brain neurochemistry and behaviour
… a possible treatment for disturbances caused by early exposure to ethanol and investigates the effects of additional early-life stress in animal models of FASD. The first study, using a third-trimester equivalent animal model of FASD (4 g/kg/day i.p., 12 % v/v, P4 - P9), investigated …
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An examination of the impact of dietary lipids on behaviour and neurochemistry
The molecular and cellular basis of stress pathology remains an important research question in biological science. A better understanding of this may enable the development of novel approaches for the treatment of stress-related disorders. There is a considerable body of scientific evidence …
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Cortisol in Middle Childhood: Associations with Genetic Polymorphisms and Early Environmental Risk
<p>Early life stress is known to have an enduring impact on individuals’ health trajectories, however, some show greater resiliency to early life stress than others. The exploration of candidate genes and gene-environment interactions may be one promising window on risk versus resilience …
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Investigations on the role of the gut microbiota in hippocampal neuroplasticity and behaviour throughout the lifespan
… regions in which new neurons are born throughout life, an ability that is critical for specific cognitive and emotional processes, making it imperative to understand the biological controls of hippocampal neurogenesis. Hippocampal neuroplasticity is shaped by factors such as aging, diet, and …
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Impacting factors for attention in children who are internationally adopted
… related to the unique experience they have with early-life stress. The current study focused on how elements of the care experienced by IA children related to attention deficits. Specifically, this study assessed how length of care and type of care related to attention. The study assessed …
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Effect of maternal separation on stress-related proteins measured in a 6-hydroxydopamine rat model of Parkinson’s disease
… vulnerable and research has implicated early life stress (ELS) as a potentiating factor to cell death in a rat model of Parkinson’s disease (PD). PD is a movement disorder resulting from the selective degeneration of dopamine neurons in the substantia nigra pars compacta (SNc). Dopamine …
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IDENTIFICATION OF NEUROMARKERS USING STRUCTURAL AND FUNCTIONAL NEUROIMAGING
… explores brain abnormalities associated with early life stress and how resilience helps in mitigating its effects. Results reveal that the neural correlates of reward processing may serve as neuroimaging phenotypes. The fourth part utilizes multimodal ensemble deep learning to predict …
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Stress and Suicidal Behavior: A Cognitive, Behavioral, and Biological Integrative Approach
… research has established distal and proximal life stress as a strong risk factor for suicidal behavior. However, how stress impacts suicidal behavior via interactive cognitive and biological mechanisms has not been thoroughly examined. The present research sought to better understand the …
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