Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Early Cancer Detection"”.
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Biomarker discovery using urinary metabolomics for noninvasive early cancer detection
"The development of new screening methods for the early detection of cancer remains one of the foremost challenges facing modern cancer research. The emergence of new analytical technologies and their application to 'omics'-based approaches has provided researchers with powerful new tools for …
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Near real-time early cancer detection using a graphics processing unit
<p>"Automatically detecting early cancer using medical images is challenging, yet very crucial to help save millions of lives in the early stages of cancer. In this work, we improved a method that was originally developed by Yamaguchi et al. from the Saga University in Saga Japan. The original …
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Development of a Fourier Domain Low Coherence Interferometry Optical System for Applications in Early Cancer Detection
<p>Cancer is a disease that affects millions of people each year. While methods for the prevention and treatment of the disease continue to advance, the early detection of precancerous development remains a key factor in reducing mortality and morbidity among patients. The current gold standard for …
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Unnatural glycopeptides with application on cancer research
… with relevant implications to fight against cancer: mucins, such as mucin-1 (MUC1), and antifreeze glycoproteins. Concerning the first mentioned class, mucins are a family of O-glycoproteins with high molecular weight that serve as cell-surface receptors and sensors. Notably, aberration in …
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Design, fabrication and testing of an acoustic resonator-based biosensor for the detection of cancer biomarkers
… is to develop this technology towards an early cancer detection capability. Specifically, I develop a solidly-mounted resonator with thin-film ZnO as my active piezoelectric layer. These resonators undergo an extensive development process to arrive at a final device design and are fully …
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INFLAMMATION INDUCED CYTOSINE DEAMINATION DAMAGE IN CANCER ETIOLOGY
Cancer is a major health challenge worldwide, and inflammation is thought to be an important factor in cancer etiology. The mutational landscape of human cancer is dominated by cytosine to thymine transition mutations, and the primary mechanism for these mutations is the deamination of cytosine and …
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Magnetically Actuated Microrobots for Tissue Elasticity Mapping in Colorectal Cancer Diagnosis
Colorectal cancer is a major global health issue, ranking among the leading causes of cancer-related mortality. Early detection significantly improves patient outcomes; however, current diagnostic methods such as colonoscopy and traditional imaging primarily rely on visual inspection, limiting …
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Solid-state nanopore sensors for nucleic acid analysis
… arrays for rapid, label-free, single-molecule detection and analysis of DNA and protein. This nano-scale technology has proven to be reliable, affordable, and mass producible, and allows for integration with VLSI processes. A detailed characterization of nanopore performance in terms of …
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INFERRING TUMOR PROPERTIES FROM GENE EXPRESSION DATA
… improved the use of transcriptome data in cancer research, benefiting both diagnostic and prognostic clinical applications. Gene expression is used to predict the tissue of origin (TOO) of tumor samples, which is relevant in several scenarios such as the diagnosis of cancer of unknown …
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Peptide Targeted Drug Delivery to Non-Small Cell Lung Cancer
Non-small cell lung cancer (NSCLC) is a notoriously deadly disease. The integrin αᵥβ₆ is emerging as a viable target for NSCLC; it is expressed in more than half of NSCLC patient tumor samples and only rarely expressed in normal tissue. Importantly, αᵥβ₆ is turned on early in the disease …
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Quantitative dynamics of T-cell receptor repertoires and their use for cancer patient stratification
… There is also evidence that TCRs that recognise cancer neoantigens undergo clonal expansion in peripheral blood and can be found at detectable clone frequencies. In this work, we explore the uses of quantitative analyses of longitudinal TCR repertoire samples in health and cancer to understand …
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Exploration of cell-free DNA’s biological properties for better understanding and improved circulating tumour DNA detection
… techniques that can be used for cancer profiling. Cell-free DNA (cfDNA) are fragmented DNA shed into circulation from various types of cells. The cfDNA derived from cancer cells, circulating tumour DNA (ctDNA), forms a subset of cfDNA. It can be challenging to detect ctDNA as it …
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Molecular characterization of methylated circulating tumour DNA biomarkers and their detection with low-cost biosensor
Diagnosing cancer at an early stage can effectively identify tumors at a time when the patient could benefit from treatments with superior clinical outcomes. Improving early cancer detection relies on discovering highly specific, sensitive, and robust biomarkers that can be obtained non-invasively …
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The Relationship Between Select Variables and the Breast Cancer Screening Practices of a Convenient Sample of African-American Women From Grambling State University and the Willis-Knighton Neighborhood Clinic
… mortality for African-American women is breast cancer. The national breast cancer mortality rate for African-American women is 28.0 per 100,000. However, African-American women residing in Northwest Louisiana have a breast cancer mortality rate of 34.5 per 100,000 (American Cancer Society; …
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Development of polymer-coated nanoparticle imaging agents for diagnostic applications
… has been made in the treatment and management of cancer, challenges remain because of the complexity and the heterogeneous nature of the disease. The improvement that has been seen in survival rates reflects advancements not only in treatment, but also in early stage detection and diagnostics for …
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Thermoacoustic Imaging and Spectroscopy for Enhanced Cancer Diagnostics
Early detection of cancer is paramount for improved patient survival. This dissertation presents work developing imaging techniques to improve cancer diagnostics and detection utilizing light and microwave induced thermoacoustic imaging. In the second chapter, the well-established pre-clinical …
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The Potential of Cellulose Nanocrystals in the Detection and Treatment of Cancer
Conventional methods of cancer therapy have been severely limited by inefficient delivery of therapeutic doses without incidence of harsh and toxic side effects in normal tissues. Consequently, countless new methods for early detection and drug delivery have been investigated in the area of …
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Enhancing Early Detection of Oesophageal Squamous Cell Carcinoma Through Shallow Whole-Genome Sequencing and Non-Endoscopic Sponge Sampling
… high, accounting for approximately 90% of the nearly half-million annual cases of oesophageal cancer globally. Although effective, conventional upper endoscopy is invasive and costly, limiting its widespread use for screening high-risk populations and surveillance of at-risk individuals, …
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Multi-Modality Plasma-Based Detection of Minimal Residual Disease in Triple-Negative Breast Cancer
Triple-negative breast cancers (TNBCs) are pathologically defined by the absence of estrogen, progesterone, and HER2 receptors. Compared to other breast cancers, TNBC has a relatively high mortality. In addition, TNBC patients are more likely to relapse in the first few years after treatment, and …