Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Early Brain Development"”.
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Dynamic Regulation of Ribosome Biogenesis and Its Role in Early Brain Development
… M. (2023b). Ribosome biogenesis and function in development and disease. Development 150.
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Thyroid hormone action and disruption in the brain: Xenopus as a model to study disruption of thyroid hormone availability on early brain development
Thyroid hormones (TH) are essential for normal brain development in vertebrates. Disruption of TH action, either due to genetic and/or environmental factors, has been implicated in neurological defects such as autism, attention deficit hyperactivity disorders (ADHD) and IQ loss. On average, over 30 …
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INVESTIGATING THE ROLE OF FEZ1 IN EARLY HUMAN BRAIN DEVELOPMENT USING CEREBRAL ORGANOIDS
… neuronal cells generated from progenitors during early cortical development contribute to neuropsychiatric disorders. Genetic interventions are known to cause these disorders but underlying mechanism remains unclear. Human FEZ1 gene is associated with a few mental diseases. In this thesis, we seek …
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Generating a proteomic profile of neurogenesis, through the use of human foetal neural stem cells
Introduction Neurogenesis, the development of new neurons, starts soon after the formation of the neural tube and is largely completed by birth. Development of the brain after birth is mainly reliant on the formation of new connections between surviving neurons. However, adult neurogenesis does …
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Magnetic resonance imaging and surface-based analysis techniques to quantify growth of the developing brain
Human brains, and those of most higher mammals, are gyrencephalic: folded) to accommodate a large cortical surface within the limited volume of the skull. Abnormal folding of the cerebral cortex in humans is associated with a number of neurological dysfunctions and diseases such as schizophrenia …
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Cellular mechanisms involved in Wnt8 distribution and function in zebrafish neurectoderm patterning
… Wnt. Wnt8 is a key signal for positioning the midbrain-hindbrain brain boundary (MHB) organizer along the anterior-posterior axis of the developing brain in vertebrates. However, it is not clear how this protein propagates from its source, the blastoderm margin, to the target cells, in the …
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Multimodal neuroimaging and early neurobehavioural and developmental correlates of alcohol and methamphetamine exposed infants in Cape Town
… disability globally. Understanding the core brain areas of susceptibility to prenatal alcohol as they manifest in early life is key to developing strategies for early focused identification and intervention. This thesis explored the relative impact of prenatal alcohol exposure on the brain in …
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Developmental trajectory of functional neocortical networks in an in vitro mouse model of Rett syndrome
Rett syndrome (RTT) is a neurodevelopmental disorder caused by loss-of-function MECP2 mutations, affecting ~1 in 10,000 female births. RTT causes progressive impairments in early life and has no cure. Despite known genetic origin in RTT, the mechanisms by which MECP2 mutations disrupt brain …
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Mechanisms of Early Brain Morphogenesis
… relationship of mechanical forces to growth and development has been well studied. In contrast, other than the problem of neurulation: formation of the neural tube), developmental mechanisms in the nervous system have received relatively little attention. The central aim of this research is to …
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Investigating the Impact of Metabolic Dysregulation on Nervous System Development and Function: A Study of CPT2 Deficiency in a Zebrafish Model System
… oxidation is an important energy source during early development and periods of starvation. Energy production is deficient when fatty acid β-oxidation is disrupted in humans, and a wide range of clinical presentations may develop. Carnitine Palmitoyltransferase (CPT) 2 is involved in the …
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Genomic Instability and the Oncohistone H3K27M Drive Gliomagenesis in a Murine Model
… of particular importance in neural cells during early brain development. Genome maintenance occurs at two broad stages; surveillance during DNA replication and DNA damage repair in differentiating and mature cells. Neural cells are particularly sensitive to DNA strand breaks and defective DNA …
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Neurobiological mechanisms of hallucinations in schizophrenia
All perception is a construct of the brain. Yet occasionally, sensory constructions emerge without origin in the physical world and are experienced as hallucinations. Hallucinations occur transdiagnostically, cross-culturally, and in all sensory modalities. They are common in people with …
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Investigating the Impact of Sleep on Early Dynamic Functional Connectivity: A High-Density Diffuse Optical Tomography Study in Term and Preterm Neonates
Poor sleep early in life has been shown to negatively impact neurocognitive functions such as attention, inhibition, and learning (McCann et al., 2018). The impact of sleep on neuronal maturation is especially critical for preterm neonates who experience environmental sleep disruptions early in …
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Role of mGluR5 and FMRP in mouse primary somatosensory cortex
The accurate development of the wiring between the billions of neurons in our brain is fundamental to brain function. Development of this connectivity relies on activity-dependent modification of synapses similar to those that underlie learning and memory. Glutamate is the principal excitatory …
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The Effects of Social Interactions on Brain Development in Infancy
… and years, leading to a sophisticated network of brain regions that emerges to handle social information. However, it is essential to consider the context in which brain development unfolds to unravel the underlying mechanisms and interpret the significance of these brain functions early in life. …