Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 54 for “"EZH2"”.
-
Gsk3Beta-Mediated Ezh2 Phosphorylation Suppresses Methylation of H3K27 and Ezh2’S Oncogenic Functions
… is a critical step. Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and the enzymatic core subunit of polycomb repressive complex 2 (PRC2), promotes cell growth and migration through catalyzing trimethylation of histone H3 at Lys 27 (H3K27me3) and plays an important role in …
-
Ezh2 T416 Phosphorylation Enhances Breast Cancer Tumorigenesis
<p>Enhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyzes the trimethylation of histone H3 on lysine 27 (H3K27Me3), to repress gene transcription. Many types of cancer stem and progenitor cells, including breast, have demonstrated EZH2 to …
-
Trim28 Interacts With Ezh2 to Regulate Its Activity
… I discovered that TRIM28 interacts with EZH2 and regulates its activity in breast cancer cells. EZH2, the major H3K27 tri-methyltransferase, is over expressed in multiple subtypes of breast cancer; however, whether EZH2 plays an active role in breast cancer progression or treatment …
-
The Role of EZH2 in the Induction and Maintenance of Acute Myeloid Leukaemia
… Activating mutations and overexpression of EZH2 occur in lymphoma and other malignancies, while loss-of-function mutations are found in myeloid malignancies. This thesis is a study of this apparent contradiction, examining the importance of cellular context for Ezh2 loss during the evolution …
-
Investigating the effects of EZH2 inhibitors on targeting epigenetic changes in head and neck squamous cell carcinoma
… from a large number of epithelial cancer cases, EZH2 inhibitors has been shown to be effectively targeting those cancers, and HPV relevance has been also taken into consideration. However, the results were not consistent and whether or not HPV infection is related to the treatment outcome and the …
-
Deubiquitinating Enzymes Promote Cancer Progression and Metastasis Via Regulating Protein Stability
… dissertation focuses on identifying the DUBs of EZH2 and SNAI1, two proteins critical for cancer progression and metastasis, and establishing these DUBs as promising anti-cancer targets.</p> <p>EZH2, the catalytic component of the PRC2 complex, silences gene transcription by histone methylation. …
-
Absence of Enhancer of Zeste Homolog 2 Promotes the Progression of KRAS-Driven Pancreatic Ductal Adenocarcinoma
… regulator Enhancer of Zeste Homologue 2 (EZH2). However, contradictory findings suggest multiple roles for EZH2. The goal of this study was to define EZH2’s contributes to early KRASG12D-driven PDAC. I hypothesized that EZH2 restricts KRASG12D initiation of PDAC in response to injury. To …
-
Targeting Epigenetic Regulators For The Treatment of Diffuse Large B-Cell Lymphoma
… inhibitors of the histone methyltransferase EZH2 hold great promise for the treatment of Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma (GCB-DLBCL). Compared to a 60% Objective Response Rate (ORR) in Phase I clinical trials, Phase II trial results for the EZH2 inhibitor EPZ-6438 …
-
The Role of Polycomb Repressive Complex 2 in Epidermal Homeostasis and Hair Growth
… homeostasis and hair growth. The expression of EZH2 was elevated in differentiating suprabasal layers of the human epidermis. Consistently, EZH1/2 expression and enzymatic activity was upregulated in differentiating primary human keratinocytes (NHEKs) in vitro. Inhibition of EZH2 and Embryonic …
-
Fasting alters histone methylation in paraventricular nucleus of chick through regulating of polycomb repressive complex 2
… [13,14] and activation [15], respectively. EZh2 (enhancer of zeste 2) in the polycomb repressive complex 2 (PRC2) is the only methyltransferase that has been linked to catalyze this methylation reaction. In addition, SUZ (suppressor of zeste) and EED (embryonic ectoderm development) are two …
-
Molecular targets of chromatin marks H3K4ME3, H3K9ME3 and H3K27ME3 in an adult germinal niche
… examination of the H3K27me3 catalyzing enzyme EZH2. In the future, the role of EZH2 will be determined by EZH2 conditional knockout and overexpression models, using stereotaxic injections of novel Cre protein and lentiviral delivery of EZH2, respectively.
-
Targeting The Redox System to Overcome Mechanisms of Drug Resistance In Chronic Lymphocytic Leukemia
… model, role of the enhancer of zeste homolog 2 (EZH2) in drug resistance, and whether use of Auranofin has any therapeutic potential in CLL. This study determined that TCL1/p53<sup>-/-</sup> had elevated expression of transcription factors which regulate mitochondria biogenesis and increase in …
-
Rejuvenation of The Epigenetic Landscape of The Aged Brain Through Manipulation of Circulating Factors
… epigenetically dysregulated, with an increase in Ezh2 function and simultaneous loss of the opposing function of Jmjd3, thereby leading to a respective increase in H3K27me3 and decrease in H3K27me1 in the brain with age. Furthermore, when we examined the role of Ezh2 in primary microglia cultures …
-
ONCOGENE-INDUCED ALTERED DNA REPLICATION DYNAMICS
… proliferation and differentiation by EZH2-mediated H3K27 trimethylation. Recent independent studies revealed a more direct PRCs role on S phase progression and DNA replication. We show that EZH2 KO leads to impairment of cell cycle progression, with cells blocked at G1/S transition. …
-
EZH1 variants disrupt neurogenesis in hPSC-derived neuronal models and cause neurodevelopmental disorders
… Repressive Complex 2 (PRC2). Its paralogue, EZH2, is essential in maintaining transcriptional repression of non-lineage specific genes during development. In neurodevelopment, EZH2 is highly expressed in dividing cells, and its dysfunction leads to defects in neural progenitor proliferation …
-
Zika Modulates Arthropod Histone Methylation in Mosquito Cells
… amounts of Enhancer of zeste homolog 2 (EZH2) histone methyl transferase-like gene transcripts and histone tri-methylation (H3K27me3) were noted in ZIKV-infected C6/36 cells in comparison to uninfected controls. Exogenous treatment with SAMe showed significant increased viral burden and …
-
COMBINATORIAL MOLECULAR PHARMACOLOGICAL AND PRECLINICAL STUDIES OF AN EPIGENETIC ANTICANCER DRUG, 3-DEAZANEPLANOCIN A, IN RATS
… the cellular enhancer of zeste homolog 2 (EZH2) protein, an enzyme responsible for modulation of histone methylation and in turn specifically induce breast cancer apoptosis. Hence, DZNep, alone or together with the other two epigenetic agents trichostatin A (TSA) and 5-Aza-2¿-deoxycytidine …
Page 1 of 3