Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"EYA1"”.
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Middle ear development: Genetics and disease
… developmental events to acquire hearing, and<br/>Eya1 mutant mice present with middle ear defects during both these developmental periods. Therefore, the aim of this project was to investigate the role of Eya1 in middle ear development and disease.<br/>Eya1 mutant mice on several backgrounds have …
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Asssessing the Liquid-Liquid Phase Separation Abilities of Eyes Absent Protein
The Eyes Absent (EYA1-4) family of proteins are critical gatekeepers for cellular responses to environmental stressors. This gatekeeping function is exerted through two pathways; EYA proteins act as a switch between proliferation and apoptosis in response to DNA damage, and directly regulate …
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Development of the Inner Ear: a Molecular, Cellular and Evolutionary Approach to Understanding the Development of the Inner Ear with an Emphasis on the Roles of Fgf10 and Foxgl
… Branchi- oto-renal (caused by mutations in Eya1 and Six1), Waardenburg’s (mutations occur in the Pax3 and MITF genes, among others), Pendred's (caused by a mutation in the PDS /pendrin gene) and Usher’s (caused by a mutation in one of several USH genes) Syndromes. In addition, over 70 …
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Sine Oculis Homeobox Homolog 1 (Six1) Plays A Critical Role In The Progression of Pulmonary Fibrosis.
<p>Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia with a median survival time of 2-4 years after diagnosis. The alarming mortality rate is due to the lack of effective treatments. IPF is a chronic disease that is characterized by alveolar destruction due to …