Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"EXOSC3"”.
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The regulation of premature termination at divergent promoters
… knockout of the essential RNA exosome subunit, Exosc3, in mouse embryonic stem cells. Removal of Exosc3 resulted in stabilization of polyadenylated uaRNAs, enhancer RNAs and long noncoding RNAs. In addition, promoter proximal pausing increased modestly upon Exosc3 removal.
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Post Translational Regulation of AID Targeting to Both Strands of a Transcribed DNA Substrate
… Knockdown of exosome core component ExoSc3 results in defects in CSR. Additionally, this work focuses on the role of the neddylation (Nedd8) of AID in recruitment to its target sequences. Neddylation, a 10kDa modifier, is a small ubiquitin like modifier which functions in a variety of …
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Pancreatic Cancer - Early Detection, Prognostic Factors, and Treatment
… could be made for BAZ2A, CDK13, DAPK1, DST, EXOSC3, INHBE, KAT2B, KIF20B, SMC1B, and SPAG5, by pathway network linkages to p53, the most frequently altered tumor suppressor in pancreatic cancer (I). An ANN survival model was developed, identifying 7 risk factors. The C-index for the model was …
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Identifying Subunit Organization and Function of The Nuclear Rna Exosome Machinery
<p><strong>IDENTIFYING SUBUNIT ORGANIZATION AND FUNCTION OF THE NUCLEAR RNA EXOSOME MACHINERY </strong></p> <p><strong>Jillian Strother Losh, A.S., B.S. </strong></p> <p>The eukaryotic RNA exosome processes and degrades many classes of RNA. It is present in the nucleus and the cytoplasm, highly …