Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"EXO1"”.
-
PARKIN, BLM AND EXO1: INVOLVEMENT IN POST-NER ACTIVITY IN NON-REPLICATING CELLS
… our laboratory has shown that the Exonuclease 1 (EXO1) is recruited on the single-strand DNA (ssDNA) ends generated by the endonucleolytic activity of NER to perform resection of the filament. While in most cases, the repair DNA synthesis activity of the replicative polymerases is faster than the …
-
Single-molecule studies reveal mechanisms of human DNA double-strand break repair
… contrast, MRN along with the long-range nuclease Exo1 and helicase BLM digests the DNA to create long 3’ single-stranded DNA overhangs, which are rapidly bound by the single-stranded DNA binding protein RPA. Next, Rad51 replaces RPA and facilitates strand exchange into a homologous chromosome to …
-
MSH2 nuclear localization and MMR apoptotic response to DNA damage.
… movement of MSH2 with the MMR repair protein EXO1, as well as an ability of the two proteins to bind with one another. Caspase-3 assay’s conducted on cells treated with either the intrastrand crosslink drug Cisplatin or the frameshift mutation drug ICR191 showed that only cells with normal …
-
New Insights into the Roles of FAN1 Nuclease in Genome Maintenance and Disease
… identify other human MIP-box proteins, including EXO1 and BLM, using<em> in silico</em> modeling I locate the MIP-box binding site (MIS) on MLH1, and using in vitro experiments I show that mutating the MIS abrogates MLH1 interaction with FAN1, EXO1, and BLM. Using biochemical assays, I show that …
-
Mechanisms That Ensure the Proper Terminal Structure of Mammalian Telomeres
… occurs at both newly-synthesized telomeres. The Exo1-mediated telomere end-processing step does not appear to require Nbs1 or BLM, and its physiologic role remains unknown. This thesis supports a model in which leading- and lagging-end telomeres have different requirements for end-processing by …
-
The role of BCLFA1 in cellular transformation
… and BAX and the DNA damage repair genes EXO1, ATRIP and BACH1. BCLAF1 deficiency also attenuated P53 expression and slightly increased P21 expression resulting in a P21-dependent G1 phase cell cycle arrest. To our knowledge, this is the first study to identify H2AX as a downstream gene of …
-
Mechanism of Mismatch Repair Induced Mutagenesis in Somatic Hypermutation
… the mismatch repair components Msh2, Msh6, and Exo1, but is additionally dependent upon the translesional DNA polymerase eta, a known A:T mutator, and on ubiquitinated PCNA, an initiator of translesion synthesis. The presence of certain types of lesions in the template strand during DNA …
-
Targeting DNA Double-Strand Break Repair to Potentiate Radio- and Chemo Therapy of Glioblastoma
… in part, by phosphorylating the exonuclease EXO1. We hypothesized, therefore, that blocking CDKs 1 and 2 might be a viable strategy for re-sensitizing recurrent tumors to TMZ. Indeed, we found that CDK inhibitors, AZD5438 and Roscovitine, could attenuate HR in the recurrent TMZ-resistant cell …
-
Control of Replication Fork Stability by Chromatin and S-phase Checkpoint
… ADN naciente que depende de Rad51, Mus81, Rad5 y Exo1. Estos resultados sustentan un modelo en el que, en ausencia del checkpoint, la acción de Rad51 y Rad5 promueve un intermediario de replicación que sirve de sustrato para el corte de Mus81 y la posterior degradación masiva por exonucleasas. …