Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"EWS"”.
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Identification of EWS-FLI1 Regions Necessary for Ewing Sarcoma Proliferation
… malignancy defined by a translocation between EWS and ETS family transcription factor. EWS-FLI1 (EF) is the most common translocation and codes for a novel transcription factor that combines the N-terminus of EWS, which contains LC domain comprised of tyrosine rich peptide repeats, and …
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Identifying CDK8/19 as a Novel Regulator of EWS-FLI1 Function in Ewing Sarcoma
… (LC) domain from an RNA binding protein (EWSR1, FUS, or TAF15) with the DNA binding domain of an ETS transcription factor. The translocation EWS-FLI1 accounts for 90% of Ewing sarcoma tumors and a large body of evidence suggests that EWS-FLI1, acting as an oncogenic transcription factor, …
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Evaluation of the Early Warning System at Banner Desert Medical Center
… and workflow of the Early Warning System (EWS) currently in use at Banner Health. Methods: A descriptive cross-sectional design was used to collect feedback from Registered Nurses. The survey was open between February and March of 2016. Likert style and open-ended questions demonstrate …
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Developing a framework for integrated community-centered early warning system to enhance disaster resilience in UAE
… have identified lack of Early Warning System (EWS) and the lack of integrated approach to disaster response as one of the reasons many deaths occur when natural disasters happen especially in developing countries. For instance, some communities in the (UAE) have suffered the impact of natural …
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Multimethode zur Bestimmung von endokrin wirksamen Substanzen in Wasser
… von verschiedenen endokrin wirksamen Substanzen (EWS) in Wasser erarbeitet. Mit einem Analysengang können Steroidhormone, Alkylphenole, Bisphenol A, Diethystilbestrol, Hexestrol, Phthalate, PCB und mehrere Pestizide zusammen bestimmt werden. Die Festphasenextraktion, die in dieser Arbeit …
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A realistic evaluation of early warning systems and acute care training for early recognition and management of deteriorating ward-based patients
… The implementation of the Early Warning Systems (EWS) and acute care training in practice is essential to the success of Rapid Response Systems but is dependent upon nurses utilising EWS protocols and applying Acute Life-threatening Events: Recognition and Treatment (ALERT) course best practice …
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Local management of a global tension : cost recovery and social equity in urban water and sanitation provision in Durban, South Africa
… thesis indicates that eThekwini Water Services (EWS), the Durban water and sanitation service provider, has had mixed success in achieving cost recovery. The agency's Water Department has moved towards improved cost recovery since 1994/95. Cost recovery for water supply in Durban is on par with …
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Estudio de los coactivadores transcripcionales TAZ y YAP1 en el sarcoma de Ewing: Implicación en la progresión tumoral e interacción funcional con la proteína de fusión EWS-FLI1
… la actividad de TAZ/YAP1 y la proteína de fusión EWS-FLI1, que, junto con la activación de la vía Wnt, podría contribuir a un estado más invasivo (EWS-FLIbajo) en el reciente modelo de diseminación metastásica propuesto en SE. Dicho antagonismo podría ser explicado, al menos en parte, por la …
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An investigation into unifying early warning prediction models
… Gupta, 1983; Ohlson, 1980; Taffler, 1983; Zmijewski, 1984) have not been unified into an early warning signal (EWS) framework according to the specific financial distress conditions they have abilities to predict. Findings also found that risk (Beneish, 1999; Schilit, 2003) and earnings …
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Genomic Characterization of Adolescent and Young Adult Cancers: Investigation of Ewing Sarcoma Susceptibility and Chornobyl Thyroid Tumors
… two different AYA cancer types: Ewing Sarcoma (EwS) and papillary thyroid carcinoma (PTC). In the EwS study, we describe the interplay between a somatic driver, EWSR1- FLI1, and a highly polymorphic GGAA microsatellite in the 6p25.1 EwS GWAS susceptibility locus, employing third generation …
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CYCLIN D1 AND WILMS TUMOR TRANSCRIPTION FACTOR-1 (WT1): POTENTIAL DIAGNOSTIC AND THERAPEUTIC MARKERS IN SMALL ROUND BLUE CELL TUMORS OF CHILDHOOD
… ganglioneuromas), Ewing s sarcoma/pPNET (EWS/pPNET), embryonal and alveolar rhabdomyosarcomas, lymphoblastic lymphoma and Wilms tumor, to assess the potential utility of these markers in the differential diagnosis of these tumors; iii) Ewing Sarcoma derived by culture of human Ewing …
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Weaning age and source of energy influence beef cattle performance, carcass characteristics, and economics
… at two locations: Early Wean Starch Diet (EWS), Early Wean Fiber Diet (EWF), Creep Fed Starch Diet (CFS), Creep Fed Fiber Diet (CFF), or Control (CON). Control calves were normal weaned and received no supplemental feed while they grazed with their dams. The diets fed to early-weaned and …
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Modeling and forecasting international credit risk : the case of sovereign loans
… inference problem in Early Warning Systems (EWSs). Second, it addresses the development of an `optimal' EWS for sovereign debt crises that accommodates the decision maker's preferences. Third, it considers the measurement of sovereign credit migration matrices using different estimators and …
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A Mechanistic Evaluation of the Role of Aneuploidy During Oncogenesis
… soft tissue tumor that is mainly driven by the EWS-FLI1 fusion oncogene. Here, we specifically investigate the molecular mechanism of one chr8 gain-driver gene, RAD21, in mitigating EWS-FLI1-induced replication stress and promoting oncogenesis. We find that the overexpression of RAD21 …
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MIR-Evaneszentwellenspektroskopie mit niedermodigen Wellenleitern
… der Anwendung der Evaneszentwellenspektroskopie (EWS), die auf dem Effekt der abgeschwächten Totalreflektion beruht. Das Verfahren wurde hierbei zum spektroskopischen Nachweis von organischen Stoffen in wässrigen Lösungen im Wellenlängenbereich des mittleren Infrarot (MIR, 2,5-25µm) eingesetzt. …
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Septic shock : providing early warnings through multivariate logistic regression models
(cont.) The EWS models were then tested in a forward, casual manner on a random cohort of 500 ICU patients to mimic the patients' stay in the unit. The model with the highest performance achieved a sensitivity of 0.85 and a positive predictive value (PPV) of 0.70. Of the 35 episodes of hypotension …
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The development, validation and testing of a vital signs monitoring tool for early identification of deterioration in adult surgical patients
… is a paucity of published early warning scores (EWS) literature for general ward use from South Africa. In a public hospital in South Africa, the study aimed to develop, validate and test the impact of implementation of a modified early warning scoring (MEWS) system vital signs chart and training …
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Identification Of Effective New Drugs Combinations Exploiting The Ability Of trabectedin To Modulate Transcription
… childhood, characterized by the chimeric protein EWS-FLI1 (hallmark of this pathology), that alters the transcription of different genes. The five-year overall survival of patients with localized disease is approximately 70%; unfortunately the majority of patients with a metastatic disease have a …
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Molecular analysis of the FET family fusion oncoprotein FUS-DDIT3
… in human cancers. The FET family genes (FUS, EWSR1 and TAF15) occur in translocations with genes encoding various transcription factors in sarcomas and leukemias. The resultant fusion genes encode chimeric protein products containing the N-terminal domain (NTD) of a FET family protein …
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