Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"ETV6"”.
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Genomic characterization of ETV6/RUNX1-positive acute lymphoblastic leukemia
The t(12;21) translocation generates the ETV6/RUNX1 fusion gene, present in 25% of childhood acute lymphoblastic leukemia. This fusion gene is important for leukemia development but is not sufficient for leukemia to arise. Hence, the additional genetic changes present in leukemic …
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Novel insights into the molecular mechanisms of endocrine resistance in ERα positive breast cancer
… together with their newly-identified interactor ETV6. The role of ETV6 in endocrine resistance was confirmed using an independent siRNA screen. In addition, the direct contribution of ETV6 to breast cancer progression was proved by the promoting effects of ETV6 overexpression on colony formation …
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Genetic Mechanisms of Transcriptional Regulation in Childhood Acute Lymphoblastic Leukemia
… 3) IGF2BP1 is transcriptionally suppressed by ETV6, 4) ZNF384-mediated fusion genes transcriptionally upregulate FLT3 expression as being a therapeutic target. Specific aims in this study include: 1) identifying the causal variant of ARID5B, 2) identifying molecular mechanism underlying drug …
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Identification and Characterization of TONSL as an Immortalizing Oncogene
… being ETS variant transcription factor 6 (ETV6). ETV6 is known to play a role as a transcriptional repressor during embryonic development and hematopoiesis. Further studies on TONSL/chromosome 8q24.3 amplification will contribute to our understanding of breast tumor initiation, progression, …
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Chracterisation of Chromosomal Aberrations in Acute Lymphoblastic Leukaemia Patients Attending the University Teaching Hospital in Lusaka
… screened, t(11;23)/MLL-AF4 and t(12;21)/ETV6/RUNX1)were not detected. There will be need to carry out this study on a larger scale nationwide in order to determine the type and frequency of chromosomal aberrations among acute lymphoblastic leukaemia patients in Zambia. Based on the above, …
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Mammary analog secretory carsinoma of salivary glands
… translokaatio t(12;15)(p13;q25), aiheutuen ETV6–NTRK3 fuusion tuotteesta. Tämän translokaation osoittamisen ohella MASC diagnostiikassa oleellisia ovat immunohistokemialliset (S-100, mammaglobin ja vimentin) värjäykset sekä spesifiset histomorfologiset löydökset. Keskeisimmät MASC:n …
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Abnormalities affecting tyrosine kinase signalling in atypical myeloproliferative disorders
… of PDGFRB have been found to have cryptic ETV6-PDGFRB fusions and overexpression of PDGFRA in one patient lead to the discovery of a previously undescribed fusion involving a novel partner gene (KIF5B).<br/>Recent evidence has indicated that acquired isodisomy is a novel mechanism by which …
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Genomics, Diagnosis, Novel Targeted Therapies and Characterisation of the Drivers of Relapse in Philadelphia Chromosome-Like Acute Lymphoblastic Leukaemia
… due to the emergence of resistance. The ETV6::JAK2 p.G993A in vitro model of JAK2 inhibitor resistant JAK/STAT activated ALL was used to investigate resistance to STAT3 and STAT5 inhibitors, pimozide and SH-4-54. Both were shown to overcome resistance. The investigation suggested the …
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Pax5 Haploinsufficiency Cooperates with BCR-ABL1 to Induce Acute Lymphoblastic Leukemia
… t(1,19)[<em>TCF3-PBX1</em>], t(12,21)[<em>ETV6-RUNX1</em>], <em>MLL</em>rearranged leukemia’s, hyperdiploid and hypodiploid karyotypes, and T-lineage leukemia. Each translocation confers a characteristic transforming phenotype within the cell in which it originates but is alone insufficient …