Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"ETV5"”.
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Role of ETV5 Mutations in B Cell Acute Lymphoblastic Leukemia
… mutations in ETS variant transcription factor 5 (ETV5), which included R392P, V444I, and T505A. It was hypothesized that ETV5 mutations alter its ability to bind target DNA sequences, resulting in altered gene expression that promotes leukemia. Electrophoretic mobility shift assays demonstrated …
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Twist1 and Etv5 are part of a transcription factor network defining T helper cell identity
… of the transcription factors Twist1 and Etv5. We demonstrate that Twist1 negatively regulates Th1 cell differentiation through several mechanisms including physical interaction with Runx3 and impairing STAT4 activation. Following induction by STAT3-activating cytokines including IL-6, …
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Mechanism of Spermatogonial Stem Cell Regulation by ETV2
… consequent infertility of ets variant gene 5 (Etv5) null mice. We show that neonatal expression of ETV5 in testis is essential for SSC maintenance and Etv5 -/- mice lose 80% of SSCs by 3 weeks of age. Etv5 -/- spermatogonial stem/progenitor cells have a decreased proliferation rate, decreased …
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Coregulatory Transcription Factors and Spermatogenesis
The BTB was hypothesized to be deficient in Etv5 -/- mice, and that this was mediated by Claudin 5 (CLD5). In both Etv5-/- and W/Wnu mice, the BTB was leaky. Examination of CLD5 expression among mice of various ages and phenotypes revealed the following: both ETV5 and germ cells were necessary for …
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Interrogation of Changes in Cell State during Tumor Evolution of a Genetically Engineered Mouse Model of Lung Adenocarcinoma
… T cells. In tumor cells, expression of Etv4 and Etv5, which belong to the Pea3 family of transcription factors, vary as a consequence of tumor progression. Etv5 regulates the identity of the cells that give rise to KP tumors, and its expression is lost as tumors evolve. Conversely, Etv4 is not …
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Transcription factors and cis-acting elements in T helper cell cytokine expression
… PU.1, BATF, and IRF4. In this study, we identify ETV5 as a factor that promotes IL-9 and IL-10 production by binding to cis-acting regulatory elements in the respective genes. At the Il9 gene, ETV5 cooperates with PU.1 in regulating gene expression. At the Il10 gene, ETV5 facilitates binding of …
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Noxious Cellular Injury Triggers an Oxidative Stress Gene Response
… TOMM6, EGR (1,2,3), HSP70 (1A, 1B), SPRY4, ETV5, and EMP1) (Fold-Change (fc) >2.0). Significantly downregulated genes were associated with many novel transcripts/proteins such as AC117378, AD000671, and AC023509. Quantitative PCR (qPCR) was used to evaluate several genes identified from …
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Studying lung development in vitro: expanding the genetic toolbox and analysis of SOX2 and SOX9 function
… and SOX9 modulates the expression of ETV4 and ETV5, which are RTK signalling effectors, thereby influencing RTK signalling. This study has marked the first effort to study gene function in human lung development using tissue derived organoids. I envision that human foetal lung organoids …