Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"ETA receptor"”.
-
ROLE OF ENDOTHELIN-1 IN THE REGULATION OF THE SWELLING-ACTIVATED Cl- CURRENT IN ATRIAL MYOCYTES
… in the activation of ICl, swell by both beta1-integrin stretch and osmotic swelling. Because endothelin-1 (ET-1) is a potential downstream mediator of AngII and ETA receptor blockade abrogates AngII-induced ROS generation, we studied how ET-1 signaling regulates ICl,swell and the …
-
Importance of MAPK and PKC in cerebrovascular endothelin receptor changes
… peptide that exerts its effect through two receptors; the endothelin type A (ETA) and type B (ETB) receptor. The contractile ETA receptor is localized on smooth muscle cells in the vascular wall, while the ETB receptors are mainly situated on endothelial cells, mediating vasodilatation. The …
-
Endothelin-1 and Hypoxic Vascular Remodeling in Ovine Fetal Cerebral Arteries
… oxygen delivery to the fetus jeopardizes fetal oxygen delivery, detrimentally affecting growth and development of the immature vasculature. Hypoxia transiently increases Hypoxia Inducible Factor-1α (HIF- 1α), which complexes with HIF-1β to form the active HIF-1 dimer that can affect …
-
Perinatal Hypoxia Exposure on the Developing Heart: The Role of Endothelin-1
… 1) <em>ex vivo </em>endothelin-1 treatment of fetal cardiomyocytes, and 2) <em>in vivo </em>anoxia episodic treatment of neonatal rats. In the first part of our study, we demonstrated that endothelin-1 exposure promoted premature terminal differentiation of cardiomyocytes. Furthermore, this …
-
Endothelin-1 is over-expressed in Amyotrophic Lateral Sclerosis and induces Motor Neuron cell death
… proliferation and reactivity. We found that both ETA and ETB receptors are enriched in astrocytes in MSCs. The ET-1 toxic effect was mimicked by ET-3 (100 nM) and sarafotoxin S6C (10 nM), two selective agonists of endothelin-B receptors, and was not additive with that of ET-3 suggesting the …
-
Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
… of vascular endothelin and angiotensin receptors. The receptor changes were studied in subcutaneous resistance arteries in patients with different degrees of ischemic heart disease (IHD). In addition, patients with giant cell arteritis (GCA) were also investigated because of the massive …