Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"ESR1"”.
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ENPP1 AND ESR1 GENOTYPE ASSOCIATE WITH CRANIOFACIAL ASYMMETRY AND SEVERITY OF TMD
… Also, we investigated whether ACTN3, ENPP1, ESR1, PITX1, and PITX2 genes which contribute to sagittal and vertical malocclusions also contribute to facial asymmetries and temporomandibular disorders (TMD) before and after orthodontic and orthognathic surgery treatment. Methods: One hundred …
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Association of Masseter Muscle PITX2, ENPP1 and ESR1 Expression, Muscle Fiber Type, Temporomandibular Joint Disorders and Subclassifications of Craniofacial Asymmetry
… genetic influences. The genes PITX2, ENPP1 and ESR1 have multiple genetic associations with functional properties in muscle and bone. The objectives of this study are to investigate how PITX2, ENPP1 and ESR1 gene expression associates with four subclassifications of craniofacial asymmetry, …
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Altered responsiveness to estrogens at estrogen receptor subtype 1 modifies the expression of circadian rhythms and daily activity patterns in mice
… rhythms via the estrogen receptor subtype 1 (ESR1) and via “non-classical” estrogenic mechanisms. I hypothesize that impaired estrogen signaling results in a decreased sensitivity to the light-dark cues that allow normal circadian entrainment. To test these hypotheses I determined if estrogen …
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Πραγματικά δεδομένα σχετικά με τις μεταλλάξεις ESR1 και την αποτελεσματικότητα του elacestrant σε ασθενείς με μεταστατικό HR(+), HER2(-) καρκίνο του μαστού: εμπειρία ενός μόνο κέντρου και ανασκόπηση της βιβλιογραφίας / Real world data regarding ESR1 mutations and efficacy of elacestrant in metastatic HR(+), HER2(-) BC patients: a single center experience and review of literature
… αντοχής είναι οι μεταλλάξεις στο γονίδιο ESR1, οι οποίες οδηγούν σε συνεχή ενεργοποίηση του υποδοχέα οιστρογόνων και μειωμένη αποτελεσματικότητα των αναστολέων αρωματάσης. Το elacestrant, ένας από του στόματος εκλεκτικός υποβαθμιστής του υποδοχέα οιστρογόνων (SERD), έχει αναδειχθεί ως μια …
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Effects of methoxychlor and its metabolites on mouse antral follicles
… mouse model in which estrogen receptor alpha (ESR1) is overexpressed (OE) in several reproductive and non-reproductive tissues. I hypothesized that the ovaries of ESR1 OE mice will be more sensitive to growth inhibition and atresia induced by MXC and its metabolites. in vitro as well as in …
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Identification of molecular signaling pathways underlying human endometrial stromal cell differentiation
… to analyze the role of estrogen receptor alpha (ESR1) and progesterone receptor isoforms (PRA and PRB) in human decidualization. Previous studies established that HESC, when treated with the differentiation cocktail containing E, P, and a cyclic adenosine monophosphate (cAMP) analog, cease …
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Molecular mechanisms regulating implantation
… studies reported here investigate E’s action via ESR1 and its downstream targets in uterine physiology and is written in three parts. The first part is an investigation of role of epithelial ESR1in the uterus during stromal cell decidualization. Earlier studies in our lab had indicated an …
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Intramammary infection in rapidly growing, non-lactating mammary glands
… number of cells expressing estrogen receptor α (ESR1) and progesterone receptor (PGR), as well as staining characteristics of ESR1 and PGR positive nuclei was also examined in these tissues. No appreciable differences were observed in any of the examined ESR1 and PGR measures between …
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Συστηματική ανασκόπηση της αποτελεσματικότητας και της ασφάλειας του Giredestrant στη θεραπεία του καρκίνου του μαστού - Systematic review on the efficacy and safety of Giredestrant for breast cancer therapy
… του ιατρού, με αριθμητικά μεγαλύτερο όφελος σε ESR1-μεταλλαγμένους όγκους. Στη νεοεπικουρική μελέτη coopERA BC, ο συνδυασμός giredestrant + palbociclib πέτυχε μεγαλύτερη καταστολή του Ki-67 και υψηλότερα ποσοστά πλήρους κυτταρικής παύσης έναντι του anastrozole + palbociclib. Η μελέτη φάσης III …
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Melatonin-Tamoxifen Drug Conjugates as Breast Cancer Drugs: Pharmacological Evaluation in Phenotypically Diverse Breast Cancer Models and Pharmacokinetic Assessment in Liver Microsome and Female Mouse Models
… receptor (MT1Rs) and estrogen receptor 1 (ESR1) were assessed. The melatonin-tamoxifen drug conjugate linked with four (C4) or five (C5) carbons demonstrated the most favorable pharmacological characteristics with respect to potency and efficacy to inhibit BC cell viability and migration. …
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Sex Specific Gene Expression Profiles In Fibrosis and Copd
… receptors, including both nuclear forms (ESR1 and ESR2) and the membrane bound G protein-coupled estrogen receptor 1 (GPER), exhibited interesting expression patterns between disease and sex. ESR1 expression was stable across the control and mild COPD groups in both males and females, but …
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Fat and Fructose Consumption Affects Pre-pubertal Gilt Reproductive Tissues and Early Embryogenesis
… for genes of interest: estrogen receptor alpha (ESR1), estrogen receptor beta (ESR2), insulin like growth factor I (IGFI), insulin like growth factor I receptor (IGFIR), and growth differentiation factor 9 (GDF9). Resulting data was analyzed in three ways: 1) across all 5 treatments, 2) with …
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Estradiol exerts activational and organizational control over the expression of daily and circadian activity rhythms in mice
… dependent upon estrogen receptor subtype 1 (ESR1) in female mice. Additionally, estradiol more uniformly distributes wheel running activity across the dark phase compared to control treatment, delays the time of peak activity (acrophase), reduces the phase angle of activity onset, and dampens …
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COMPREHENSIVE WHOLE GENOME SEQUENCING UNRAVELS THE COMPLEX GENOMIC LANDSCAPE OF NEUROBLASTOMA
… point mutations in 3 cancer-related genes, ESR1, MYH9 and SKI, the latter under-expressed in high-risk tumors. Focal and numerical copy number alterations associated with high and low risk tumors, respectively. Genomic rearrangement analysis revealed novel and recurrent translocations. …
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Role of Cuzd1 in mammary gland development and tumorigenesis
… a high level of estrogen receptor alpha (ESR1) and ERBB signaling. Collectively, these findings suggested that uncontrolled expression of CUZD1, which is a unique integrator of steroid- and EGF family-induced growth pathways in normal mammary epithelium, leads to breast tumorigenesis. …
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Circadian modulation of the estrogen receptor alpha transcription
… regulation of ERα through the repression of esr1 by Per2 in MCF-7 cells.
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Identification of Markers to Predict Benefit from Trastuzumab Treatment
… characterised by high <i>ERBB2</i>/low <i>ESR1</i> expression, with good clinical outcome, and allowed the development of a trastuzumab risk model (TRAR) able to identify patients with high- and low-risk of relapse. Application of TRAR model to available datasets and to a new series of …
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Molecular Epidemiology of Breast Cancer
… possibly associated with breast cancer in the ESR1 gene. We also examined previously identified common variants affecting breast cancer risk by replicating them in the same five cohorts and examining how the risk increased with increasing number of risk-alleles. A highly significant increasing …
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Development of a Neoepitope Prioritization Platform to Identify Immunogenic Neoantigens from Oncogenic FGFR3-TACC3 Fusion in Glioblastoma
… dataset comprising FGFR3-TACC3, CD74-NRG1, and ESR1-PRKN across multiple HLA alleles, improving predictive robustness and specificity. Functional validation using ELISpot assays demonstrated that 9 of 10 fusion derived in vitro validated binders induced significant IFN-γ secretion from CD8 T …
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Breast Cancer Risk - Environmental and Genetic Effects on Cancer Development, Progression and Survival
… penetrance mutations including FGFR2, CASP8 and ESR1. Additionally environmental factors influence risk, including reproductive factors, alcohol consumption, smoking and social deprivation. Of the factors identified in this literature review there was evidence that there may be common biological …
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