Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"ESKAPE"”.
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The role of lipid A in the virulence of ESKAPE pathogens
<br/>The exponential growth of antimicrobial resistance worldwide is one of the most<br/>concerning threats to mankind in the modern era. Gram-negative bacterial<br/>infections are of particular concern and have been identified as an urgent threat by governmental organisations. The Gram-negative …
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Microorganismos y perfiles de resistencia en aislamientos de infecciones quirúrgicas intraabdominales en un Hospital de Bogotá – Colombia, 2017 – 2018
… del mundo, como microorganismos catalogados como ESKAPE principalmente relacionados con infecciones de origen intrahospitalario y con perfiles de resistencia que evidenciaban una baja resistencia respecto a los reportes referenciados.
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The effect of environmental stress on antibiotic production by streptomyces
… to 'last-resort' antibiotics, these are the 'ESKAPE' pathogens.To face this problem, we investigated novel antibiotic-producing bacteria. The majority of currently available originate from organisms belonging to the Actinobacteria Phylum. Unfortunately, no significant compounds have been …
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Analogues of Nitrofuran Antibiotics are Potent GroEL/ES Pro-drug Inhibitors with Efficacy against Enterococcus Faecium, Staphylococcus Aureus, and Escherichia Coli
In 2019, the ESKAPE pathogens were highlighted by the World Health Organization as some of the most prominent threats to human health, capable of developing significant antibiotic resistance. These pathogens contribute to over 2 million annual infections and ~23,000 annual deaths in the U.S. In …
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A study of the transmission pathways of organisms associated with nosocomial infections at a veterinary academic hospital
… caused by bacterial organisms mainly from the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). Within the veterinary settings, this group of organisms is often zoonotic and tends to …
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Structural and mechanistic studies on antimicrobial peptides that target multi-drug resistant bacteria
… activity against Escherichia coli and other ESKAPE pathogens (including carbapenem-resistant Acinetobacter baumannii). Interestingly, these analogues were resistant to enzymatic degradation in the presence of recently reported D-stereoselective peptidases. <br/><br/>Secondly, brevicidine …
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Discovery of bioactive peptides from amphibian skin secretion
… potent antimicrobial activity against planktonic ESKAPE strains and the yeast, C. albicans, but also inhibited and eradicated the biofilm of S. aureus and MRSA. Therefore, a mice model was used for evaluating its further in vivo antimicrobial activity. <br/><br/>In Chapter 4, a novel dermaseptin …
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Novel collective prey evasion response of Pseudomonas aeruginosa PAO1 to soil micropredator Myxococcus xanthus DK1622
… infections. <em>P. aeruginosa</em> is also an ESKAPE pathogen, which are leading causes of nosocomial infections throughout the world, and they are often multi-drug resistant. When standardized spots of micropredator <em>Myxococcus xanthus </em>DK1622 and prey were placed 1 millimeter apart on …
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Síntesis y caracterización de complejos metálicos de Ir(III), Rh(III) y Ru(II). Estudio de su actividad citotóxica en células cancerígenas y de su uso en reacciones de (des)hidrogenación catalítica por transferencia
… y su actividad antimicrobiana frente patógenos ESKAPE (principal causa de infecciones nosocomiales). Finalmente, se exploran los mecanismos a través de los cuales ejercen su actividad biológica, la cual puede ser de diversa naturaleza. Estos estudios tienen como objetivo principal entender los …
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Targeting infectious species by Structure-guided Fragment-based Drug Discovery and in silico approach
… well-characterised highly virulent species of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter subspecies) reported by the Centers for Disease Control and Prevention (CDC) and the World Health …
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Desenvolvimento de hidrogéis à base de Carbopol 940® contendo sistemas de nanoprismas de prata/azul de metileno para inativação fotodinâmica de bactérias patogênicas
… (MDR) em patógenos nosocomiais do grupo ESKAPE tem aumentado gradualmente. Staphylococcus aureus e Pseudomonas aeruginosa são especialmente relevantes e persistentes em infecções bacterianas, com diversos mecanismos de resistência que dificultam o tratamento eficaz. O objetivo geral deste …
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PART I: SYNTHESIS OF PHENOLIC ANTIBACTERIALS AND NATURAL PRODUCTS PART II: RAPID ASSESSMENT OF HYDROGEN BONDING CAPACITY
… the structure-activity relationships against the ESKAPE pathogens. Compounds with high therapeutic indices (hemolysis20/MIC) were identified. In particular, ester-linked compounds that would be less environmentally durable than biaryl ether antibacterials such as the broadly used triclosan were …
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Biopelículas bacterianas de tubo-orotraqueal y su sensibilidad antimicrobiana en dos ucis en Bogotá, Colombia
… a microorganismos pertencientes al grupo ESKAPE, K.pneumonia fue el microorganismo mas prevalente en las dos unidades de cuidado intensivo en la evaluación de formación de biopelicula y asi mismo es el de mayor capacidad de formación de la misma seguido por P. aeruginosa. Se realizó la …
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Ancient Triassic Halite as a novel source of antibiotic chemical diversity
… activity against the clinically relevant ESKAPE pathogens. The capacity of haloarchaea to modulate bacterial quorum sensing via the production of cross-domain induction and inhibitory compounds were also investigated.<br/><br/>Both conventional and enhanced culturing methods including the …
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ANTIMICROBIAL CHARACTERIZATION AND THERAPEUTIC APPLICATIONS OF NOVEL SYNTHETIC THIAZOLE COMPOUNDS AGAINST MULTIDRUG-RESISTANT STAPHYLOCOCCI AND ENTEROCOCCI
… against a panel of clinically-relevant ‘ESKAPE’ pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). The lead compound 1 was identified through whole-cell screening of libraries of …
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Manipulating PLGA nanoparticle cellular uptake and trafficking
Nanotechnology is one of the most exciting and fast-moving areas of science today. A wide range of medical applications use nanoscale materials in the diagnosis, treatment, and prevention of various diseases. Nanoparticles (NPs) are being extensively studied as drug delivery systems due to their …
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Exploring the Polyclonal Antibody Responses Induced by Klebsiella pneumoniae Derived Outer-Membrane Vesicles
… number of AMR-related deaths globally. These “ESKAPE” pathogens are Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. Of these, Klebsiella pneumoniae stands out due to its vast genomic diversity with only a …
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Assessing Vulnerabilities to the Spread of Pathogens and Antibiotic Resistance in Agricultural and Water Systems Using Culture-, Molecular-, and Metagenomic-based Techniques
… analysis of these systems targeting resistant ESKAPE pathogens (Escherichia coil, Staphylococcus aureus, Klebsiella spp., Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterococcus spp.) indicated similar trends as the metagenomic ARG analysis for both systems, but was challenged by …