Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 209 for “"ESI-MS"”.
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In Vitro Metabolism Study of Brevetoxins by LC-ESI-MS
… coupled with electrospray mass spectrometry (LC-MS). For the incubation sample of brevetoxin- 1, two metabolites were found: brevetoxin-1-M1 and brevetoxin- 1-M2. The tandem mass spectrometry study of the [brevetoxin-1- M1+H]+ led to the conclusion that it was formed by converting one double bond …
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ANALYSIS OF PHARMACEUTICALS AND BIOMOLECULES USING HPLC COUPLED TO ICP-MS AND ESI-MS
The work described within this thesis explores the use of HPLC coupled with ICPMS and ESI-MS in order to develop novel methods which overcome specific analytical challenges in the pharmaceutical industry. A membrane desolvation interface has been evaluated for coupling high performance liquid …
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LC-ESI-MS/MS quantification of hair cortisol, cortisone and DHEA in combined oral contraceptive users
… many COC adverse effects coincide with symptoms of stress-related illnesses, including insulin resistance and hypertension, it is believed that these adverse effects are a result of chronic biological stress from long-term COC use and that COC users are at greater risk of developing …
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Metabolic Studies on 1-Cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridinyl Derivatives by HPLC and LC-ESI/MS
… ionization mass spectrometry (LC-ESI/MS) based methods have been developed for metabolite detection and characterization. From the UV spectral data and pseudomolecular ion species observed by LC-ESI/MS, we have identified N-oxide, C-hydroxylated, and pyridinium metabolites. For the …
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Detection of human salivary α-Defensins by LC-ESI-MS and evaluation of levels in athletes after physical stress
… of this study was to optimise and validate an LC-ESI-MS method to determine the level of individual human neutrophil alpha defensins (HNP1-4) after physical stress. A method for the analysis of individual (HNP1-4) in a saliva matrix by LC-ESI-MS has been established. An Agilent 1200 series HPLC, …
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Structural Studies on the Estrogen Receptor Ligand Binding Domain Using Electrospray Ionization Mass Spectrometry
A protocol using LC/ESI-MS and LC/ESI-MS/MS was developed and used successfully to identify the site covalent attachment of the photoaffinity label hexestrol diazirine. The application of tandem MS/MS sequencing permitted the identification of several residues near the C-terminus of the protein.
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Electrospray ionization mass spectrometry for the analysis of proteins and small molecules
… by Electrospray Ionization Mass Spectrometry (ESI-MS) are discussed. Section I contains an introduction to ESI-MS, including a brief history of mass spectrometry, a discussion of the current theories developed to explain the mechanisms at work during the electrospray process, and an explanation …
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Hyphenation of analytical techniques to single cell capillary electrophoresis-mass spectrometry
… cells within the same tissue. Mass spectrometry (MS) has emerged as an effective tool for single cell chemical analysis because of its versatility, sensitivity, and ability to distinguish analytes in complex samples. Different MS approaches have various advantages and disadvantages for chemical …
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Surfactant Assisted Electrospray Ionization Time of Flight Mass Spectrometry of Synthetic Polymers
… Electrospray Ionization Mass Spectrometry, ESI-MS, is capable of providing a wealth of information on biomolecules, inorganic compounds, and small synthetic polymer (molecular weight less than 3,000 g/mol). While ESI-MS has proven to be a powerful characterization technique for small …
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Mikroreaktor-gekoppelte Elektrospray-Ionisations-Massenspektrometrie: ein neues Werkzeug zur Untersuchung von reaktiven Zwischenstufen in Lösung
… Elektrospray-Ionisations-Massenspektrometrie (ESI-MS) optimiert und auf ihre allgemeine Anwendbarkeit hin untersucht. Diese weiterentwickelte Methode erlaubt die massenspektrometrische Verfolgung von Reaktionsabläufen über die Abnahme der Edukte und dazugehörigen Zunahme der Produkte und im …
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Enhanced Electrospray Ionization for Mass Spectrometry and Ion Mobility Spectrometry
Electrospray ionization (ESI) has become one of the most commonly used ionization techniques for mass spectrometry (MS) and ion mobility spectrometry (IMS), and efforts continue to improve its performance. ESI-MS is most recognized for its wide application to biomacromolecules where high …
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An investigation of beryllium coordination chemistry using electrospray ionisation mass spectrometry
… of beryllium have been investigated in this thesis. These beryllium complexes were prepared in situ on a small scale by preparing appropriate molar mixtures of the Be²⁺ ion with ligands in a range of solvent systems. In view of the toxicity of beryllium compounds, this combinatorial type …
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Bioanalytical Methods Development for Detection and Characterization of Labile Metal Pools in Escherichia Coli
… regulation, and signaling in biological systems. Their chemical identities remain largely unknown due to their rapid ligand-exchange rates and weak metal-ligand bonds. Lack of chemical characterization unfortunately precludes biological function. In this dissertation, methods were developed …
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Analyzing A-series gangliosides in neurons following exposure to glutamate
… use electrospray ionization mass spectrometry (ESI-MS) technique and immunohistochemistry to evaluate the temporal changes in the expression profiles of various ganglioside species during the course of neurodegeneration in rat primary cortical neurons exposed to glutamate toxicity. Primary …
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The Development Of Peptide Ligands To Target H69 Rrna
… of peptide ligands to target H69, SPPS and ESI MS was used to determine if 1) peptides could bind to modified H69 and 2) if increased affinity for the target RNA could be enhanced with modification. An alanine and arginine scan was synthesized and tested for this determination. Selected …
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A Reinvestigation of Salvarsan and Related Arsenic Chemistry.
… Salvarsan for the treatment of syphilis. This thesis presents a detailed review of the history and literature leading up to and following on from Ehrlich’s discovery and thoroughly investigates the chemistry of Salvarsan and related species. A series of arylarsonic acids was prepared and fully …
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