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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 83 for “"ESCs"”.

  1. Tumor-like growth of mouse embryonic stem cells

    Li, YanzhenUniversity of Illinois at Urbana-Champaign2011

    … and differentiation, embryonic stem cells (ESCs) are an invaluable tool for research in regenerative medicine. However, the main problem that hampers application of ESCs to practical stem cell therapies is that ESCs can grow as tumors when transplanted. To date, only one oncogene Eras is …

    uiuc Repository record

  2. Control of Regulatory Element Function by Histone H3.3

    Tafessu, Amanuel Melesse2024

    … elements in mouse embryonic stem cells (ESCs) and found evidence of subtle yet widespread dysregulation in the absence of H3.3. Loss of H3.3 or HIRA- the chaperone responsible for H3.3 deposition to transcriptionally active regions- reduces chromatin accessibility and transcription factor …

    utswmed Repository record

  3. Effects of HOXB4 downstream targets on the haemopoietic differentiation of pluripotent stem cells

    Kydonaki, MariaThe University of Edinburgh2016

    … of reconstituting human HSCs from ESCs have been unsuccessful as key factors of HSC specification remain unclear. Enforced HOXB4 expression can enhance haemopoietic differentiation of mouse and human ESCs and generate reconstituting HSCs from mouse ESCs. We have previously shown …

    edinburgh Repository record

  4. Comparative Analysis of Antiviral Responses in Mouse Embryonic Stem Cells and in Mesenchymal Stem Cells

    Wang, Jundi2018

    <p>Embryonic stem cells (ESCs) are cells that have unlimited capacity for selfrenewal and differentiation. These properties make ESCs a great cell source for application in regenerative medicine. When used for cell therapy, ESC-derived cells could be placed in a wounded area that is likely to be …

    usm Repository record

  5. MicroRNA Expression Profiling of Multipotent Adult Germline Stem Cells

    Zovoilis, Athanasios2012

    … und Pluripotenz von Embryonalen Stammzellen (ESCs) spielen. Das Ziel dieser Arbeit war es, Ähnlichkeiten und Unterschiede zwischen maGSCs und ESCs im Bezug auf miRNAs zu untersuchen. Ein Gesamt-miRNA Array zeigte trotz geringen Unterschieden in der Expression von einigen Oncomirs, dass …

    goettingen Repository record

  6. Genome-wide search for regulators of the first cell lineage decision in the mouse: a CRISPR/Cas9 endeavour

    Freitas Antunes, LilianaUniversity of Cambridge2019

    … embryonic counterparts: embryonic stem cells (ESCs) are pluripotent and similarly to ICM contribute to all tissues in the embryo proper, being generally excluded from the extraembryonic layer. On the other hand, trophoblast stem cells (TSCs) resemble TE and are restricted to the extra-embryonic …

    cambridge Repository record

  7. Quantitative dynamic modeling of transcriptional networks of embryonic stem cells using integrated framework of Pareto optimality and energy balance

    Avila, Marco A., Ph. D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2009

    Embryonic Stem Cells (ESCs) are pluripotent and thus are considered the "cell type of choice". ESCs exhibit several phenotypic traits (e.g., proliferation, differentiation, apoptosis, necrosis, etc.) and when differentiated into a particular lineage they can perform an array of functions (e.g., …

    mit Repository record

  8. microRNA expression profile of undifferentiated and differentiating pluripotent cells

    Pantazi, Angeliki2012

    … im Vergleich zu differenzierten ESCs (Embryonic Stem Cells-embryonale Stammzellen) in der Maus. Dazu wurden globale miRNA Array Expressionsprofile von nicht differenzierten und differenzierten ESCs und maGSCs auf 129/Sv Hintergrund (die differenzierten Zellen wurden 21 Tage unter …

    goettingen Repository record

  9. Attenuated Responses To Inflammatory Cytokines In Mouse Embryonic Stem Cells: Biological Implications And The Molecular Basis

    Chen, Bohan2021

    <p>Embryonic stem cells (ESCs) have attracted intense interest due to their great potential for regenerative medicine. However, their immune property is an overlooked but a significant issue that needs to be thoroughly investigated not only to resolve the concern for therapeutic applications but …

    usm Repository record

  10. Microfluidic Devices for the Investigation of Pluripotency in Embryonic Stem Cells

    Hodgson, Andrew ChristopherUniversity of Cambridge2017

    … research into mouse embryonic stem cells (ESCs). ESCs are a well-studied cell, largely due to their pluripotent nature, meaning they are able to differentiate into all cell types of the body and may self-renew indefinitely in appropriate culture conditions. ESCs, along with many other lines …

    cambridge Repository record

  11. Cell-cell and cell-medium interactions in the growth of mouse embryonic stem cells

    Mittal, Nikhil, 1979-Massachusetts Institute of Technology2010

    … Due to the potential for embryonic stem cells (ESCs) to provide a variety of tissues for use in regenerative medicine, there has been great interest in the identification of factors that govern the differentiation of ESCs into specific lineages. Much of this research builds on previous studies …

    mit Repository record

  12. Lack of Inflammatory Response in Mouse Embryonic Cells to Listeria Infection

    Oyebode, Damilola2025

    … blastocysts, including embryonic stem cells (ESCs) and trophoblast stem cells (TSCs), exhibit remarkable resilience against the cytotoxic effects associated with viral infections and embryotoxic cytokines, such as TNFα and IFNγ, both of which are known to hinder blastocyst development. …

    usm Repository record

  13. Progesterone control of human endometrial cells

    Dunn, Carolyn LouiseThe University of Edinburgh2004

    … progesterone in endometrial stromal cells (ESCs) in vitro. Uterine Natural Killer (uNK) cells increase in number in secretory phase endometrial stroma, implying the control of progesterone on their expansion. However, they lack the nuclear progesterone receptor and growth and differentiation …

    edinburgh Repository record

  14. THE ROLE OF DNA REPAIR IN DNA METHYLATION DYNAMICS

    Gould, Poppy AeronUniversity of Cambridge2018

    … demethylation of a static system – primed serum ESCs and a dynamic system – serum to 2i (naïve) to epiblast-like ES cells. As the role of both AID and UNG involves genomic uracil, the central theme of my thesis is the impact of accumulation of uracil on DNA methylation levels in the genome. …

    cambridge Repository record

  15. Role of small RNAs and chromatin in transposable element silencing during global demethylation

    Berrens, Rebecca VUniversity of Cambridge2017

    … early embryo and in naïve embryonic stem cells (ESCs). Genome integrity is crucial during early development, as the germline DNA needs to be protected for future generations. Therefore, epigenetic reprogramming presents a critical phase for TE defence since presumably alternative silencing …

    cambridge Repository record

  16. The Functions of Setd5 and Mir-221 In Embryonic Stem Cell Differentiation

    Chen, Tsai-Yu, <p>https://orcid.org/0000-0001-6150-6361</p>2018

    <p>Embryonic stem cells (ESCs) are a widely used model system to study cellular differentiation because of their pluripotent characteristics, and ESC differentiation is an epigenetic process. In an effort to identify a new epigenetic factor that is required for ESC differentiation, the function of …

    uthsc Repository record

  17. Biophysical and gene expression change in living cells by force-induced mechanotransduction

    Poh, Yeh ChuinUniversity of Illinois at Urbana-Champaign2013

    … extend our study to mouse embryonic stem cells (ESCs). Increasing evidence suggests that mechanical factors play a critical role in fate decisions of stem cells. We demonstrate that forces transmitted through different natural extracellular matrix proteins or cell-cell adhesion molecules such as …

    uiuc Repository record

  18. Investigating the role of Neuronatin in neural development

    Lin, Hsuan-HwaiKing's College London2012

    … and loss-of function experiments I show that ESCs in which Nnat expression had been knocked-down have a dramatically decreased ability to generate NSCs, and subsequently neurons, while ESCs that over-expressed Nnat generate an excess of NSCs and neurons. I reveal that Nnat interacts directly …

    kings Repository record

  19. Signaling pathways regulating self-renewal, differentiation, and multipotency of CD133+ umbilical cord blood stem cells

    Margaret Corbett HoweThe University of Texas Medical Branch2008

    … factor essential for self-renewal in ESCs that we previously reported expression in UCBSCs. During our studies, new challenges in the field arose. Two isomers of Oct-4 were discovered, Oct-4A and Oct-4B 3, in which only Oct-4A conferred the ability of ESCs to self-renew 4. We …

    utmb Repository record

  20. A multi-lineage in vitro mouse embryo model derived exclusively from mouse embryonic stem cells

    Lau, YuiUniversity of Cambridge2023

    … Using only mouse embryonic stem cells (ESCs), the gastruloid model has been demonstrated to mimic basic body axis formation and aspects of gastrulation, somitogenesis, cardiogenesis, and neurulation. However, it fails to recapitulate the spatiotemporal interplay of signalling pathways …

    cambridge Repository record

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