Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"ESCRT proteins"”.
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Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the expression and functional roles in neurodegenerative diseases
Endosomal Sorting Complex Required for Transport (ESCRT) is responsible for trafficking of misfolded proteins, unwanted organelles and ubiquitinated proteins to be degraded by lysosome. Abnormalities in ESCRT proteins have been linked to various neurodegenerative diseases such as Alzheimer's …
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Visualizing Protease Activation, Retrochmp3 Activity, and VPR Recruitment During HIV-1 Assembly
… and involves a number of viral and host proteins to produce infectious virions. Although many of these factors have been studied extensively, there are still steps during viral assembly that have yet to be fully characterized. In Chapter 2 of this thesis, I will discuss my study of the …
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Glycoprotein M and ESCRT in herpes simplex virus type 1 assembly
… tegument layer. There are over fifty viral proteins and many host proteins identified in HSV-1 virions. The final formation of mature virus particles requires the membrane wrapping of tegumented capsids in the cytoplasm, a process termed secondary envelopment. This process involves the …
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CBL and CBL-B Dictate CSF-1R Endocytic Traffic and Signaling in Macrophages
… observed in DKO mice. The CSF-1R and associated proteins were not ubiquitinated in DKO macrophages, unlike single knockouts and wild-type cells suggesting redundant functions of Cbl and Cbl-b. Mapping of the CSF-1R traffic demonstrated that CSF-1R internalization was slower in DKO cells, …
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Using Chemical Probes to Examine Cellular Activities
… sorting complex required for transport (ESCRT) to the reforming nuclear envelope, where spastin is proposed to sever stable microtubules. However, we currently lack an understanding of spastin's dynamics during anaphase, particularly the roles of microtubules and ESCRT proteins in said …
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Characterization of The Ubiquitin Ligase, Ube4B, In Endocytic Trafficking
… is a process by which cells internalize membrane proteins to remove them from the plasma membrane, allowing cells to regulate the cell surface expression of transmembrane proteins. In this manner, cellular responses to extracellular cues may be tuned by limiting the number of proteins available at …