Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"ERp57"”.
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The Role of ERp57 in Hras Intracellular Trafficking and Function.
… transport from the endomembrane system. ERp57, an ER chaperone, has been shown to specifically bind farnesylated Hras but not non-farnesylated Hras. The objective of this study was to determine if ERp57 participates in Ras trafficking and function. First, the effect of ERp57 knock down by …
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Contribution of LEDGF/p75 to Prostate Cancer Chemoresistance
… in the expression of the thiol-oxidoreductase ERp57 was observed in overexpressing cells. Transactivation of ERp57 by LEDGF/p75 was confirmed using transcription reporter assays, providing evidence that ERp57 might be a target gene of LEDGF/p75. However, there was incomplete correlation in the …
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The Potential Role of LEDGF/p75 in Prostate Cancer
… of the endoplasmic reticulum protein 57 (ERp57), a thiol-dependent reductase. Taken together, these results suggest that overexpression of LEDGF/p75, which may be triggered by the oxidative stress environment in the prostate, might provide a growth advantage to prostate cells through the …
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Disulfide Bond Formation: Identifying Roles of PDI Family Thiol Oxidoreductases and ER Oxidant Pathways
… catalyst of oxidative folding. In comparison, ERp57 acts preferentially on glycosylated substrates, ERp72 functions in a more supplementary capacity, and P5 has no detectable role in formation of disulfide bonds for the substrates assayed. Initially, no impact of depletion of Ero1 was observed …