Global ETD Search
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Showing 1 to 3 of 3 for “"ERdj4"”.
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The endoplasmic reticulum chaperone ERdj4 is required for survival, glucose metabolism and B cell development
The ER-localized DnaJ homologue 4 (ERdj4) is a soluble ER chaperone induced by the unfolded protein response (UPR) to assist in the removal of unfolded/misfolded proteins from the ER lumen for proteasomal degradation. To elucidate the function of ERdj4 in vivo, ERdj4 gene trap mice were generated …
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Regulation of mammalian IRE1α: Co-chaperones and their importance
… that identify a role of the ER co-chaperone ERdj4 as an IRE1 repressor that promotes a complex between the luminal Hsp70 BiP and the luminal stress-sensing domain of IRE1α (IRE1LD). This is then built on by a series of in vitro experiments showing that ERdj4 catalyses formation of a …
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Stress-signal recognition in the unfolded protein response
… showing that the luminal J-domain co-chaperone ERdj4 promotes the formation of a complex between BiP and IRE1's stress-sensing luminal domain (LD) *in vitro* using recombinantly expressed proteins. This observation suggests that the interaction with BiP favours IRE1α LD’s monomeric, inactive …