Global ETD Search
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Showing 1 to 20 of 20 for “"EROD"”.
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Hepatic CYP1A enzymes in fish as a biomarker of water pollution
… Measurement of ethoxyresorufin-O-deethylase (EROD) and aryl hydrocarbon hydroxylase (AHH) enzyme activities in fish liver microsomes were used to monitor CYP1A enzyme activity. Optimal conditions for salmon husbandry in laboratory studies were established. Laboratory experiments were carried …
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Effects of Pycnogenol on Microsomal Cytochrome P450 Activity and Apoptosis
… benzyloxyresorufin (BROD), ethoxyresorufin (EROD) and methoxyresorufin (MROD) linked to CYP2B1,2C6 and 1A2, respectively. Pycnogenol significantly inhibited BROD, EROD and MROD activity in 6 mo and 20 mo liver microsomes and inhibited BROD activity but enhanced EROD and MROD in both 6 mo and …
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Molecular regulation of the induction of cytochrome P-450E in the estuarine fish Fundulus heteroclitus
… correlated with ethoxyresorufin O-deethylase (EROD) activity. EROD was strongly inhibited by MAb 1-12-3 in scup and trout. PAb inhibited AHH and EROD more than 90%, inhibited ethoxycoumarin O-deethylase by about 60%, and did not inhibit aminopyrine N-demethylase, confirming the identity of …
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Effects of ibuprofen on Rainbow Trout (Oncorhynchus mykiss) following acute and chronic waterborne exposures
… concentration and ethoxyresorufin-O-deethylase (EROD) activity were evaluated following waterborne ibuprofen exposure of trout to 1 and 10 mg/L in the acute exposure and 1, 32 and 1000 μg/L in the chronic exposure, along with an experimental control, E2 control of 1000 μg/L and an E2-ibuprofen …
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Chronic effects of single intra-peritoneal injection of endosulfan on rainbow trout (Oncorhynchus mykiss) and field observations of caged rainbow in Oshawa Creek
… levels, liver ethoxyresorufin-O-deethylase (EROD), citrate synthase (CS), lactate dehydrogenase (LDH), and brain acetylcholine esterase (AChE) (caged fish only) enzymatic activities were measured. Trout injected with endosulfan experienced an increase of the anaerobic (LDH activity) and a …
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Inhibitory Effects of Isothiocyanates on the Mutagenicity and Metabolism of Environmental Carcinogens
… PhIP and on the dealkylation of ethoxyresorufin (EROD) and methoxyresorufin (MROD) were investigated. All four isothiocyanates significantly inhibited the oxidation of NNK by hamster liver microsome. The isothiocyanates enhanced the reduction of NNK by hamster liver microsome. The ability of the …
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Xenobiotic metabolism and markers of genotoxicity in regulatory non-vertebrate ecotoxicological test species
… (via 7-ethoxyresorufin-O-deethylase or EROD activity) of both organisms to be measured. C. reinhardtii and D. magna possessed low, but measurable, basal EROD activity (0.03 pmol/minute/106 algal cells and 7 fmol/minute/daphnid). In C. reinhardtii, a 48h exposure to β-naphthoflavone (0.2 …
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Combined effects of bioavailable organic contaminants in the aquatic environment.
… cytotoxicity (i.e. neutral red uptake assay) and EROD induction potential using rainbow trout liver cell line (Oncorhynchus mykiss; RTL-W1). They were also evaluated for phytotoxicity and developmental toxicity potential, using an algal growth inhibition test with a marine phytoplankton …
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The fathead minnow embryo as a model for the development of alternative testing methods in ecotoxicology.
… zebrafish embryo in the newly developed in vivo EROD assay (Kais) was performed successfully. However, first sig-nals of EROD activity were detected at least 24 hours later than in the zebrafish, and the sig-nal intensity was weaker than in zebrafish.
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Enhanced vermiremediation of hydrocarbon contaminated land using biosurfactant: an integrated approach
… by examining the monooxygenase activities (EROD and MROD activity of cytochrome P450 [CYP1A1 and CYP1A2]) and the antioxidase activity (GST activity). A 28-day experiment was conducted by exposing the two species of earthworms in soil spiked with selected 3, 4 and 5 ringed hydrocarbons …
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Feminization in common terns (Sterna hirunda) : relationship to persistent organic contaminants
… highly correlated with TCDD-EQs. Tern hepatic EROD activity was relatively insensitive to induction; only when TCDD-EQs were above 82 ± 26 ng/g lipid were EROD activities elevated. Levels of organic pesticides were below levels thought to be of toxicological significance. The percentage of male …
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The anti-estrogenic and liver metabolic effects of DHAA in rainbow trout (oncorhynchus mykiss)
… (CS), and liver ethoxyresorufin-O-deethylase (EROD) activity after 7 days, however, the fish recovered by 28 days. This study also determined the effect of 14 different pulp and paper mill effluent extracts on liver enzyme metabolism through alterations in the activity of liver lactate …
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Characterisation of mammalian cytochrome P450 enzymes by their metabolic activities.
… formation of harmol and H1, and also with both EROD and MROD activities, and the concentration of CYP1A in the 16 human liver microsomal preparations. This suggests the involvement of CYP1A2 in the metabolism of harmine by human liver microsomes. Inhibition studies with selected anti-P450 …
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Synthesis and Evaluation of Naturally Occuring Halogenated Bipyrroles in a Relevant Marine Species, Fundulus Heteroclitus
… several of these analogs exhibited significant EROD induction, to negative and positive controls DMSO and PCB126, respectively.
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Immunological and hematological biomarkers for contaminants in fish-eating birds of the Great Lakes
… activity of liver ethoxyresorufm-O-deethylase (EROD), an index of HAH-exposure and Ah-receptor activation, increased. In Caspian tern and herring gull chicks, the phytohemagglutinin skin test for T cell function showed a strong negative exposure-response relationship with organochlorines. There …
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Monitoraggio dell ambiente marino costiero del Golfo di Catania attraverso la specie bioindicatrice Engraulis encrasicolus
… (HSP70); l'ethoxyresorufin-O-deethylase (EROD). Inoltre, poiché nella comunità scientifica sta crescendo sempre di più l'interesse di conoscere i reali rischi per la salute umana, derivanti dall esposizione alimentare ai composti chimici, sono stati valutati i tassi di ingestione per …
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Sexual patterns of monooxygenase function in the liver of marine teleosts and the regulation of activity by estradiol
… than males. Ethoxyresorufin O-deethylase (EROD) activity in microsomes from females of both species was less than or equal to activity in males, reflecting sexually differentiated levels of the responsible isozyme, P-450E. Estradiol (E2) 2-hydroxylation, demonstrated here for the first time …
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Ricerca, mediante tecniche di proteomica, di biomarcatori proteici utili nella valutazione della qualità degli alimenti di origine animale
… activity of 7-etossi-resourifine-O-deetilase (EROD linked to xenobiotic biotransformation processes) during exposure, underline the major effects of B[a]P action. The identification of basal levels of EROD supports the possible presence of CYP1A subfamily in the invertebrates, still today …
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Responses of wild freshwater fish to anthropogenic stressors in the Waikato River of New Zealand
… variables, hepatic ethoxyresorufin-O-deethylase (EROD) and plasma steroids indicated exposure and response of brown bullhead and shortfin eel to pulp and paper contaminants at the BKME site. Physiological (blood) variables showed fish largely responded in a predictable way to elevated water …
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The role of penguins in the Recycling of Trace Metals in Antarctica and their Ecological Impact
… decrease in antioxidant enzyme activities (e.g. EROD, GST and GR) upon exposure to guano were observed in the Antarctic clams. Lastly, a clear avoidance response was observed in amphipods, indicating that guano could shape the structure of amphipod communities, before reaching toxic levels.