Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"ERK5"”.
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The Role of ERK5 in Dopamine Neuronal Survival
… age-related decrease in phosphorylated/activated ERK5 (p-ERK5) was observed in the SN and STR, whereas an increase in total ERK1 was observed in all three regions. Higher expression of total and phosphorylated ERK5 was observed at postnatal day zero (PND0) in all dopaminergic regions, which …
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The role of ERK5 signalling in macrophage behaviour during wound healing
… regulator of macrophages in other contexts, ERK5, influences wound healing, using genetic and therapeutic manipulations targeted at ERK5, both in vitro and in vivo. Genetic in vivo hyperactivation of ERK5 causes a persistent inflammatory profile in wounds, which aligned with similar …
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Identification of the ERK5 Kinase as a Key Regulator of Embryonic Stem Cell Pluripotency
… show that selective compounds which inhibit both ERK5 and BET family bromodomains drive ESCs from the naïve state towards primed pluripotency. Using compound selectivity engineering and CRISPR/Cas9 genome editing, I deconvolve distinct functions for ERK5 and BRD4 in pluripotency regulation. …
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Analysis of the role of extracellular signal regulated kinase (ERK5) in the differentiation of muscle cells
The MEK5/ ERK5 kinase module is a relatively new discovered mitogen-activated protein kinase (MAPK) signalling pathway with a poorly defined physiological function. Since ERK5 and its upstream activator MEK5 are abundant in skeletal muscle a function of the cascade during muscle differentiation was …
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Dual Inhibition of the PI3K/Akt and MEK5/ERK5 Pathways for the Treatment of Breast Cancer
… mechanisms. New evidence suggests that MEK5/ERK5, a member of the MAPK family, is a crucial component in the proliferation and survival of several aggressive cancers. We hypothesize that inhibiting both PI3K/Akt and MEK5/ERK5 pathways will decrease cell viability while maintaining limited …
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Unraveling The Effects of Aerobic Exercise and Erk5 Signaling In The Solid Tumor Microenvironment Using Murine Models
… to elucidate the effects of aerobic exercise and ERK5 signaling. We found that aerobic exercise normalizes tumor vasculature and improves chemotherapy efficacy in certain tumor models and that the ERK5 axis regulates tumor vascular permeability. By utilizing a novel mouse model, we demonstrated …
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Age-Related Effects on the Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways in Breast Cancer and the Characterization of Novel MEK5 Inhibitors
… signal-regulated kinases, ERK1/2 and ERK5, of the mitogen-activated protein kinase (MAPK) pathway, and in the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway. Further, the role of the MEK5-ERK5 cascade in breast cancer cell proliferation, migration, and invasion was analyzed. In …
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Substrate Interaction and Sub-Cellular Localization in Map Kinase Pathways
… extracellular signal-regulated kinases, ERK2 and ERK5 are two closely related enzymes that have overlapping functions in a number of cellular pathways. Sub-cellular localization and specificity towards substrates are two mechanisms of controlling the function of an enzyme in the cell. My …
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Regulation of Adult Neurogenesis by the ERK5 MAPK Signaling Pathway and its Functional Implications in Learning and Memory as well as Olfaction
… on adult neurogenesis per se. We identified ERK5 MAP Kinase as a novel protein specifically expressed along both neurogenic regions in the Type 1 neural stem/progenitor and Type 2 transiently amplifying progenitor or newborn neuron cell populations. This result posits the involvement of the …
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Investigation of a Novel Mitophagy Regulatory Pathway and Chemical Inducer
… autophagy regulators to identify the MEKK3-MEK5-ERK5 pathway as a potential regulator of mitophagy in the absence of exogenous damage. Here, I provide evidence that genetic or pharmacological inhibition of the MEKK3-MEK5-ERK5 pathway increases mitochondrial content by reducing lysosome-mediated …
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The Effect of Resveratrol on Lipopolysaccharide-induced Dopaminergic Deficits and BV-2 Cell Activation
… the extracellular regulated kinases, ERK1/2 and ERK5, the downstream targets in the mitogen-activated protein kinase (MAPK) pathway, has been shown to be involved in the dysregulation of the inflammatory process (Cuschieri and Maier, 2005). Consequently, LPS-induced activation of ERK1/2 and ERK5 …
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Serine 910 Phosphorylation of Focal Adhesion Kinase Is Critical for Costamere Assembly
… Src via parallel Raf-1→MEK1/2→ERK1/2 and MEK5→ERK5 signaling pathways. Using co-immunoprecipitation, TIRF-microscopy and FRAP, ET-1 stimulation of NRVM expressing a nonphosphorylatable, S910A-FAK mutant decreased the interaction of paxillin and vinculin within costameres. This interaction was …
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Studies on signaling pathways induced by FLT3, an important oncogene in AML
… inhibit FLT3 and to determine the role of MEK5/ERK5 signaling in FLT3-ITD mediated transformation. Using phosphospecific antibodies, we have identified 3 novel phosphorylation sites in FLT3, Y726, Y793 and Y842, and studied their kinetics and specificity. The additional eight phosphorylated …
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Design, Synthesis, & Biological Evaluation of Novel Het-Aromatic/Aromatic Analogs for the Treatment of HIV, Cancer, & Cognitive Dysfunctions
… metastasis, and chemo-resistance. The MEK5/ERK5 pathway, which is a member of MAPK signaling cascade, is involved in cell survival, anti-apoptotic signaling, angiogenesis, and cell motility. It is found to be significantly upregulated in breast cancers especially triple-negative breast …
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Molecular pathway analysis and therapeutics development in post-traumatic osteoarthritis
… key regulatory kinases, p38, JNKI/2, ERKI/2, ERK5, JAK2, and STAT3 that were upregulated in phosphorylation as a result of inflammatory cytokine treatment. In addition, we identified 417 phosphopeptides with MAPK substrate motif that were more than 4 times upregulated in response to cytokine …
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The Effect of L-DOPA and Natural Products on Age-Related Motor Deficits and Dopaminergic Cell Survival
… and the expression and activation of ERK1/2 and ERK5, kinases known to protect from oxidative stress, were examined in DA cells. Resveratrol and pinostilbene decreased DA-induced cell death and activated ERK1/2, but not ERK5. Pretreatment with U0126, an inhibitor of the ERK1/2 pathways, blocked …
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Design, Synthesis and Evaluation of Diphenylamines as MEK5 Inhibitors
… signal-Regulated Kinase) substrate. The MEK5/ERK5 pathway is involved in cell survival, anti-apoptotic signaling, angiogenesis, and cell motility. It is significantly up-regulated in specific tumor types including breast and prostate cancers. A novel series of compounds utilizing the …
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With No Lysine (WNK) Family Proteins and Their Interaction with Downstream Kinases
… to the extracellular-signal regulated kinase 5 (ERK5) pathway. One effector for WNK1 is oxidative stress responsive 1 (OSR1), a sterile20-like kinase. All four WNKs are able to phosphorylate OSR1 and stimulate its activity toward an ion transporter substrate, to roughly a similar degree. The WNKs …
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Regulation of cell fate by phosphorylation : a tale of two transcription factors
… of the transcriptional regulators EYA, DBP1, ERK5, p300, and TAFII250.
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