Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"ERK1/2 signalling"”.
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ERK1/2 signalling and protein ubiquitylation in the control of apoptosis
… apoptosis are tightly regulated by cell fate signalling pathways. The ERK1/2 signalling pathway is a key regulator of cell intrinsic apoptosis, in part through regulation of the pro-apoptotic protein ‘BCL2-interacting mediator of cell death’ (BIM). BIM is phosphorylated by ERK1/2 and this …
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Functional assessment of BRAF and CRAF through Base Editor 3 mutagenesis reveals residues and regions critical for ERK1/2 signalling
The RAS-regulated RAF-MEK-ERK1/2 signalling pathway is critical for transducing extracellular signals from receptor tyrosine kinases at the plasma membrane through to protein targets to direct cell fate. Components of this pathway are frequently mutated to drive enhanced signalling in cancer and a …
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Exploiting tumour cell dependency on pro-survival BCL2 proteins with BH3 mimetics
The RAS-RAF-MEK1/2-ERK1/2 signalling pathway is one of the most frequently deregulated pathways in human cancer, with mutations in KRAS and BRAF commonly occurring in cancers of the pancreas, skin, and colon, among others. Indeed, BRAF and MEK1/2 inhibitors are approved for the treatment of …
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RET receptor activation targets expression of the pleiotropic cytokine interleukin-11
… and is dependent on activation of the RAS/ERK1/2 signalling pathway. Examination of thyroid carcinoma cell lines with activated RET indicated that PTC-derived TPC-1 cells express IL-11. Addition of exogenous IL-11 stimulated STAT3 phosphorylation in thyroid cancer cell lines, though IL-11 …
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Regulating the bioactivity of placental growth factor in the aging outer retina as a new therapeutic approach to age-related macular degeneration
… PlGF treatment of RPE increased permeability via ERK1/2 signalling and altered ZO-1 localisation. In chapter 3 the anti-PlGF antibody THR-317 inhibited the effects of PlGF on RPE, however could not protect against hypoxia or oxidative stress. In a co-culture model, THR-317 improved barrier …
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Investigation of mTOR-independent regulation of macroautophagy
… explores the role of CMGC kinase family members ERK1/2 and CCNB1-CDK1 in the regulation of autophagy. The ERK1/2 signalling cascade is activated in a high proportion of cancers. ERK2 has been proposed as a regulatory kinase of TFEB; however, we found little evidence to suggest that ERK1/2 was a …
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The role of microRNA-194 and microRNA-375 in prostate cancer metastasis
… leads to activation of the JAK2/STAT3 and ERK1/2 signalling pathways, two key pathways involved in promoting PCa metastasis. Further, I have demonstrated that miR-194 is regulated by GATA2, an oncogenic transcription factor in PCa. On the other hand, my work demonstrated that miR-375 is a …
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Investigating the role of cell cycle regulators in mesoderm specification
… Using this tool, I showed that developmental signalling pathways such as BMP and WNT are active in all cell cycle phases indicating that alternative mechanisms are involved in the differentiation process. In order to further explore these mechanisms, I investigated the role of cell cycle …
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Oncogene-induced reprogramming of heterotypic cellular interactions
KRAS is a critical signalling hub that orchestrates fundamental cellular decisions such as cell survival, proliferation and differentiation. Activating mutations in KRAS are among the most frequently occurring oncogenic mutations driving cancers that are particularly refractory to therapy (e.g., …
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The effects of prenatal and early-postnatal ethanol exposure on rat brain neurochemistry and behaviour
… to the extracellular signal-regulated kinase1/2 (ERK1/2) and glycogen synthase kinase-3-beta (GSK3β) signalling cascades, using two different animal models of FASD. Further, to elucidate additional mechanisms underlying the deficits observed in FASD, proteomic profiles were determined in order to …