Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 239 for “"ERK1"”.
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Nuclear Behaviors of ERK1/2 Signaling
… cells. Many pathway functions are carried out by ERK1 and ERK2 (ERK1/2), serine/threonine protein kinases that interact with a large number of substrates in several cell compartments. ERK1/2 are crucial for major cellular phenomena such as proliferation, differentiation, and programmed cell death. …
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Regulation of ERK1/2 and SAPK/JNK Phosphorylation by Histamine
… in allergic disease and asthma and SAPK/JNK and ERK1/2 are involved in certain aspects of allergic inflammation such as TH2 differentiation and proliferation and apoptosis. This study was designed to investigate the effects of histamine on ERK1/2 and SAPK/JNK phosphorylation in …
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Regulation by ERK1/2 of Novel Substrates, Kinesins KIF2A and KIF2C
… human KIF2A can be v phosphorylated in vitro by pERK1/2 and that the kinases interact with KIF2A in cells. Through phosphorylation prediction tools and mutagenesis we identified threonine 78 (T78) as a major pERK2 phosphorylation site on KIF2A. Inhibition of ERK1/2 prevents KIF2A from localizing …
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ERK1/2 signalling and protein ubiquitylation in the control of apoptosis
… regulated by cell fate signalling pathways. The ERK1/2 signalling pathway is a key regulator of cell intrinsic apoptosis, in part through regulation of the pro-apoptotic protein ‘BCL2-interacting mediator of cell death’ (BIM). BIM is phosphorylated by ERK1/2 and this serves to drive its …
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Endothelin-1 Induced Phosphorylation of ERK1/2 in Bovine Corneal Endothelial Cells
… (BCECs) involves MAPK pathway by phosphorylating ERK1/2 protein kinase and to find out the phosphorylation patterns of ERK1/2 in confluent and sub-confluent cells. BCECs were isolated from bovine corneas and cultured in medium supplemented with 10% serum. Confluent (contact inhibited) and …
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The Regulation of Cellular Localization of Both Active and Inactive ERK1/2
… to the extracellular signal regulated kinase1/2 (ERK1/2) cascade is how the cellular response to different ligands, cellular environment, and other cellular signals is generated. Part of the answer to the question is the ligand and context-specific spatial control of ERK1/2 in the cell. By …
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Regulation of Mitochondrial Morphology by ERK1/2-Mediated Control of Mfn2 Stability
… 관해서는 아직 명확하지 않다. 본 연구는 동일한 종류의 primary 배양세포에서ERK1/2의 활성화 정도에 비례하여 미토콘드리아가 짧아지는 현상의 발견으로부터 연구를 시작하게 되었다. ERK1/2는 외부의 다양한 자극에 반응하여 세포성장, 증식, 분화 및 세포의 생(生)과 사(死)를 조절하는 세포 내 필수 kinase 로 최근의 연구에서 ERK1/2가 미토콘드리아 외 막과 내막에 모두 국재(localization) 한다고 보고되었다. 이는 ERK1/2에 의한 신호전달과 미토콘드리아 간에 직접적인 상관관계가 있음을 …
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Regulation and Dysregulation via Docking Interactions in WNK and ERK1/2 MAPK Signaling
… cellular signaling pathways, the WNK, and ERK1/2 MAPK pathways. The WNK pathway is an essential regulator of cellular ionic composition and volume. Initially discovered due to the genetic link between mutations in some of the WNK kinases and an inherited form of hypertension, the pathway is …
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BASIGIN-2 MEDIATED ACTIVATION OF ERK1/2 SIGNALING IN HUMAN GLIOBLASTOMA MULTIFORME CELLS
… Kinase (MAPK) signaling pathway proteins, ERK1/2. This effect was mediated by rBsg-ECD binding to the Basigin-2 (Bsg-2) at the cell surface. In this research, U87-MG human GBM cells were treated with purified rBsg-ECD protein to measure changes in the phosphorylation of the ERK1/2 proteins. …
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Identification and Characterization of the Multifunctional Epigenetic Regulator CFP1 as an ERK1/2 Substrate
… by the mitogen activated protein kinases ERK1/2. In a yeast two-hybrid screen with activated ERK2 (extracellular signal-regulated kinase 2) to find novel interacting partners, our lab identified CFP1 (CxxC finger protein 1), a DNA-binding protein that is a vital component of the H3K4 …
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Regulatory Factors of Cellular Senescence in Human Diploid Fibroblast : SA-p-Erk1/2, PP1/2A, PKCα
… Extracellular signal-regulated kinase 1/2 (Erk1/2) is one of the mitogenactivated protein kinase (MAPK). Erk1/2 signaling promotes cell proliferation and cell surnival. Ironically, p-Erk1/2 level is up-regulated in senescent cells. In the present study, the mechanism of …
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Erk1 and Erk2 in hematopoiesis, mast cell function, and the management of Nf1-associated leukemia and tumors
… show increased latency and potency of active Erk1 and Erk2, the principal cytosolic-to-nuclear effectors of canonical Ras-Raf-Mek signaling. Thus, Erk represents a potential regulator of leukemogenesis and tumor-associated inflammation. However, single and combined Erk1 and Erk2 roles in HSC …
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Mitochondrial Instability, Lack of Erk1/2 Activation and High Expression of P75NTR in Engrailed-Deficient Mesencephalic Dopaminergic Neurons
… of the extracellular signal regulated kinase1/2 (Erk1/2) pathway. Additionally, there is an inverse correlation between expression of P75 and phosphorylation of Erk1/2, suggesting that Erk1/2 deactivation is critical to the death signaling of P75. This study shows a connection between the etiology …
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Functional assessment of BRAF and CRAF through Base Editor 3 mutagenesis reveals residues and regions critical for ERK1/2 signalling
The RAS-regulated RAF-MEK-ERK1/2 signalling pathway is critical for transducing extracellular signals from receptor tyrosine kinases at the plasma membrane through to protein targets to direct cell fate. Components of this pathway are frequently mutated to drive enhanced signalling in cancer and a …
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Characterization of the Glycosylation and Signal Peptide Sequences Within the Vaccinia Virus M2 Protein and Influence on ERK1/2 and Nf-Kappab Activation
… as a viral immunomodulator to inhibit both the ERK1/2 and NF-kappaB pathways, which is reliant on its glycosylation status and proper cellular trafficking within the infected cell. As M2 has no homology to any known viral or cellular protein, this suggests a novel immunoregulatory function. Data …
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Characterization of the glycosylation and signal peptide sequences within the vaccinia virus m2 protein and influence on ERK1/2 and NF-kB activation
… was shown to reduce NF-κB activation, and also ERK1/2 activation, an early event in MVA infection. Understanding the molecular basis for M2- mediated inhibition of NF-κB and ERK1/2 activation was the primary goal of this dissertation. Characterization of the M2 protein began with an examination …
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The role of extracellular signal-regulated kinases (ERKs) in T lymphocytes
… was to evaluate the role of the MAP kinases ERK1/2 in naïve and effector CD8 T lymphocytes. Initial experiments showed that inhibition of ERK1/2 activation impaired protein synthesis and reduced cell growth and proliferation of T cell antigen receptor (TCR) stimulated naïve CD8 T cells. On …
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Isoform-Specific Roles of Extracellular Signal-Regulated Kinases in Pain
… signal-regulated kinase: ERK) isoforms, ERK1 and ERK2, are believed to be key signaling molecules in nociception and nociceptive sensitization. Studies utilizing inhibitors targeting the shared ERK1/2 upstream activator, mitogen-activated protein kinase kinase: MEK), and transgenic mice …
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