Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"ERK inhibitor"”.
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Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
… transcriptional factors and STATS signaling, the ERK pathway is also involved in regulating or fine-tuning T cell lineage commitment. ERK differentially regulates Tregs and Th17 cell development by positively regulating Th17 and negatively regulating Treg cell differentiation. My studies indicated …
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Adaptive immune responses in intestinal homeostasis and experimental inflammatory bowel disease
… transcriptional factors and STATS signaling, the ERK pathway is also involved in regulating or fine-tuning T cell lineage commitment. ERK differentially regulates Tregs and Th17 cell development by positively regulating Th17 and negatively regulating Treg cell differentiation. My studies indicated …
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Role of Extracellular Signal-Regulated Kinase and Peroxisome Proliferator-Activated Receptor gamma on Transforming Growth Factor-β1-Induced Human Endometrial Stromal Cell Decidualization
OBJECTIVE: To investigate the role of ERK and PPAR gamma on TGF-β1-induced human endometrial stromal cell decidualization in vitro. MATERIALS AND METHODS: Human endometrial tissues obtained by hysterectomy specimens from patients with conditions other than endometrial diseases such as leiomyoma. …
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The role of the rho-associated coiled-coil containing kinase (ROCK) in cytokine-induced chemokine responses in intestinal epithelial cells
… suppression was likely mediated by ERK since the MEK/ERK inhibitor, PD98059, had the same enhancement effect as the ROCK inhibitor on TNF-α-induced CCL2 secretion. These results suggest that ROCK plays a complex role in chemokine production in IEC. Furthermore, since ROCK appears to …
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Chrysophanol-8-O-glucoside Attenuates Platelet Activation Through Inhibiting MAPK and PKCε
… (CP-8-O-glc) was found to have the most potent inhibitory effect on collagen- and thrombininduced platelet aggregation. CP-8-O-glc-treated mice showed significantly prolonged bleeding times. Furthermore, CP-8-O-glc-glucoside was found to have a significant inhibitory effect on rat platelet …
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Novel Strategies in Cardioprotection against Ischemia/Reperfusion Injury
… concentration. Sildenafil is a potent selective inhibitor of PDE-5 and therefore allows the accumulation of cGMP in several tissues shown to express PDE-5, including pulmonary and coronary arteries. We initially hypothesized that vasodilation induced by sildenafil may release several endogenous …
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Erk1 and Erk2 in hematopoiesis, mast cell function, and the management of Nf1-associated leukemia and tumors
… show increased latency and potency of active Erk1 and Erk2, the principal cytosolic-to-nuclear effectors of canonical Ras-Raf-Mek signaling. Thus, Erk represents a potential regulator of leukemogenesis and tumor-associated inflammation. However, single and combined Erk1 and Erk2 roles in HSC …
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Regulation and function of interphase histone H1 phosphorylation in pluripotent cell differentiation
… are not affected by these transcription inhibitor treatments, and selective inhibition of CDK2 does not affect global phosphorylation of H1.4-S187 or H1.5-S18. Although Erk phosphorylates S187-H1.4 in vitro, our data with Erk inhibitor treatments and EGF stimulation suggest that Erk does …
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Development of a novel co-culture based in vitro model system to study the wound healing process
… Treatment with 1 mM OTC reduced activation of ERK1/2 and p38 mitogen-activated protein kinases (MAPK) at 21 days post-surgery suggesting potential anti-scarring mechanism. However, large animal to animal variation in the expression levels of collagen biosynthesis markers made it difficult to …
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The Role Of ROS-mediated ERK and JNK Activation In The Induction Of Autophagy And Apoptosis In Tumour Cells By A Novel Small Molecule Compound
… activation of extracellular regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). Inhibition of ERK and JNK virtually completely blocked drug-induced autophagy and apoptosis. Interestingly, inhibition of JNK activity reversed C1-induced increase in Atg7 expression, indicating that JNK may …
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MECHANISMS OF NEUROPROTECTION IN SCN2.2 CELLS
… in SCN2.2 cells. Extracellular regulated kinase (ERK) is expressed in the SCN, activated by Glu, and is anti-apoptotic in other systems. Therefore, this thesis was designed to test the following central hypothesis: SCN2.2 cells are dependent on ERK signaling for survival in the presence of an …