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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 27 for “"ERK MAPK"”.

  1. PPARγ agonism attenuates cocaine seeking behavior via association with ERK MAPK

    Miller, William RyanThe University of Texas Medical Branch at Galveston2016

    … is thought to underlie relapse behaviors. ERK, a protein vital for learning and memory, is altered by cocaine use and abstinence. Our lab demonstrated PPARγ agonism rescued cognitive impairment in an animal model of Alzheimer’s disease and that this rescue involved ERK. Given the role of …

    utmb Repository record

  2. The interferon alpha receptor utilises T-cell receptor-associated proteins for signalling

    Stevens, C.N.UCL (University College London)2009

    … outcomes, both the TCR and IFNAR activate the ERK MAPK signalling pathway, albeit with a different time course. Furthermore, studies have shown that the IFNAR and TCR utilise an overlapping subset of proteins for this pathway to occur such as CD45, Lck and Zap70. In this study evidence is …

    ucl Repository record

  3. PPARγ-pERK interaction restores memory consolidation in an Alzheimer’s disease model

    Jahrling, JordanThe University of Texas Medical Branch at Galveston2017

    … protein kinase mitogen-activated protein kinase (ERK MAPK) is required for many forms of learning and memory that are affected in AD, and since both PPARγ and ERK are key mediators of insulin signaling, we tested the hypothesis that RSG-mediated cognitive improvement induces a hippocampal PPARγ …

    utmb Repository record

  4. A Phase I Dose-Escalation Study of The Braf Inhibitor Vemurafenib In Combination With The Mtor Inhibitor Everolimus In Subjects With Advanced Cancer

    Munoz, Javier2016

    … in various other malignancies. The RAS/RAF/MEK/ERK (MAPK) pathway is critical to cell proliferation in many human cancers. The mTOR inhibitors are well known to exert profound anticancer effects across malignancies through inhibition of the PTEN/PI3K/AKT/mTOR (mTOR) pathway. We hypothesize that …

    uthsc Repository record

  5. The Mechanism of the Gastric Epithelial Stem Cell Response to Metaplastic Injury

    Khurana, Shradha Sachin2015

    … CD44 and/or proliferation and found only ERK MAPK was activated during early stages following injury: as few as 6 hours following tamoxifen injection). This burst of ERK activation is localized to non-differentiated cells of the isthmus, and blocking ERK activation with the inhibitor U0126 …

    wustl Repository record

  6. Involvement of Platelet-Derived Growth Factor, PDGF Receptor Signaling, Focal Adhesion Kinase and SRC in Pressure-Induced Vascular Smooth Muscle Hypertrophy

    Rice, Darian Clark2019

    … sensitive. The signaling molecules FAK, Src and ERK-MAPK are known to be triggered by integrin engagement and growth factor receptor tyrosine kinase (RTK) activation. Pairs of rat mesenteric arteries were pressurized to 90 mmHg (control), and then one was raised to 140 mmHg for 1, 3, 5 or 10 …

    odu Repository record

  7. Molecular Mechanisms by Which HSP90 Inhibition in the Spinal Cord Enhances Opioid Receptor Signaling

    Gabriel, KatherinThe University of Arizona.2022

    … HSP90 is inhibited in spinal cord using 17-AAG, ERK MAPK signaling, and subsequent opioid anti-nociception is enhanced. Quantitative proteomic analysis on the spinal cords of CD-1 mice treated with 17-AAG revealed that both 5' AMP-activated protein kinase subunit beta-1 (AMPK) and Epidermal …

    arizona-thes Repository record

  8. U0126, MEK1/2 inhibitor, Induces Adhesion Molecules Expression in Human Blood Cells

    박, 성례2011

    … inflammatory responses in vascular lesion. MAPKinase pathway has been known to be activated in inflammatory responses. In this study, we investigated the expression of adhesion molecule by MEK1/2 inhibotors such as U0126 in human blood cells, U937 cells. Cell viability was determined by MTT …

    ajou Repository record

  9. Age-related impairments in memory and in cholinergic signaling due to reduced blood glucose responses to epinephrine

    Morris, KennethUniversity of Illinois at Urbana-Champaign2013

    … mediates the calcium-dependent activation of the ERK/MAPK and CREB signaling cascades, which are widely implicated in activity-dependent neuronal plasticity. Age-related deficits in brain glucose availability may limit these cholinergic signaling processes and produce memory impairments. This is …

    uiuc Repository record

  10. Die Rolle mitogener und stressinduzierter MAPK-Signalwege in der Regulation von keratinozytären Wachstums- und Differenzierungsvorgängen

    Schmidt, MarcUniversität Würzburg

    … Rolle in der Pathogenese vieler Hauterkrankungen. Die intrazellulären Signalmechanismen, die die Balance zwischen Keratinozytenwachstum und -differen-zierung steuern, sind bislang weitgehend unbekannt. In dieser Arbeit wurde die Bedeutung Mitogen-aktivierter Proteinkinase (MAPK-) …

    wurz-thes Repository record

  11. Regulation of Tumor Necrosis Factor-alpha Signaling in Rheumatoid Arthritis Synovial Fibroblasts by Green Tea Polyphenol Epigallocatechin-3-gallate

    Riegsecker, SharayahUniversity of Toledo Health Science Campus2013

    … modestly inhibited JNK and p38 with no effect on ERK MAPK in RA synovial fibroblasts. Inhibition of TNF-a-induced downstream signaling pathways by EGCG resulted in decreases in IL-6 and IL-8 production by RA synovial fibroblasts. Overall, the results of this study suggest that EGCG decreases the …

    ohiolink Repository record

  12. Induction of Synthetic Lethality In Mutant Kras Cells For Non-Small Cell Lung Cancers Chemoprevention and Therapy

    Huang, Shaoyi2014

    … (c-FLIP) expression through activation of ERK/MAPK-mediated activation of c-MYC which means the mutant <em>KRAS</em> cells could be specifically targeted via TRAIL induced apoptosis. The expression level of Inhibitors of Apoptosis Proteins (IAPs) in mutant <em>KRAS</em> cells is usually …

    uthsc Repository record

  13. Multi-omic characterisation of Barrett’s oesophagus reveals a molecular continuum in the progression to oesophageal adenocarcinoma

    Katz-Summercorn, AnnaliseUniversity of Cambridge2020

    … there is an upregulation of genes in the ERK/MAPK pathway. In summary, BE is a heterogeneous disease that shows a continuum of abnormalities in the progression towards cancer. We hypothesise that it is the accumulation of events that tip the balance to progression, rather than a stepwise …

    cambridge Repository record

  14. Molecular mechanisms involved in the anticancer activity of BISPMB in oesophageal cancer cells

    Siyo, Vuyolwethu PenelopeDivision of Medical Biochemistry2016

    … the endoplasmic reticulum and also deregulated MAPK pathways in WHCO1 cells. At a protein level, bisPMB was found to induce an increase in protein ubiquitination and in the expression of ER stress and UPR genes ATF4, Grp78 and CHOP in WHCO1 cells. We also observed a decrease in ATF6 90 kDa …

    cape-town Repository record

  15. Investigating the role of the Epstein-Barr virus-encoded oncoprotein, latent membrane protein 1, in cell transformation in vitro

    Davis, Alexandra M.De Montfort University2020

    … that is abrogated by inhibition of both TGFβ and ERK/MAPK signalling in fibroblasts. Moreover, results presented herein demonstrate that fibroblast recruitment is enhanced by LMP1-conditioned medium. Since a growing body of evidence suggests that 3D cell culture systems mimic the in vivo TME more …

    de-montfort Repository record

  16. Characterization of Fasting-Induced p21 Expression and Protection of Intestinal Stem Cells

    Tinkum, Kelsey Lynn2016

    … cells demonstrated that p53 prevented the ERK/MAPK pathway from activating <italic>p21</italic> expression when quiescent cells were stimulated with serum to re-enter the cell cycle. In addition, low light bioluminescence imaging identified <italic>p21</italic> expression in specific …

    wustl Repository record

  17. Human Cytomegalovirus and the Neutrophil

    Pocock, Joanna MaryUniversity of Cambridge2018

    … receptors, but is dependent on activation of the ERK MAPK and NFκB signalling pathways, and is viral strain-dependent, restricted to clinical strains of the virus. Furthermore, HCMV triggers the secretion of a bioactive secretome that induces a similar paracrine anti-apoptotic effect in fresh …

    cambridge Repository record

  18. The Role of The Epithelial-To-Mesenchymal Transition (Emt) In Lung Cancer Progression

    Peng, David H, <p>0000-0003-0511-1888</p>2018

    … transition (EMT) as a regulator of MAPK-dependent signaling activity and tumor maintenance in lung cancer cells. Mechanistic studies in novel cell line and animal models further demonstrated that the Ras-Raf-Mek-Erk MAPK signaling cascade in epithelial cells is activated through …

    uthsc Repository record

  19. Re-evaluation of the in vitro activity of the protease activated receptor-1 (PAR1) pepducin PZ-128

    Fortuny-Marti, LidiaUniversity of Strathclyde2020

    … cell viability assessment, pAkt and pERK quantification, and receptor localisation studies.;TsA201 and HEK293 cells were used as they express endogenous levels of PAR1 and can be transfected with PAR1 tagged plasmids. Studies with PZ-128 (palmitate-KKSRALF-NH2) were carried out in …

    strathclyde Repository record

  20. Investigation of the host-mediated proteolytic response to pulmonary Mycobacterium Avium Complex infection

    McFetridge, SarahQueen's University Belfast2020

    … the p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases (MAPK), the phosphatidylinositol-3 kinase (PI3K)/Akt, and nuclear factor kappa-lightchain-enhancer of activated B cells (NF-κB) pathways, and induced activator protein -1 …

    qu-belfast Repository record

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