Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 465 for “"ERK"”.
-
REGULATION OF ERK SIGNAL TRANSDUCTION BY SIGNAL-INDUCED CYSTEINE OXIDATION
The ERK1/2 pathway plays roles across eukaryotic biology by transducing
-
ATM-Dependent ERK Signaling in Response to DNA Double Strand Breaks
… BrdU photolysis on the major cellular signaling ERK pathways. Interestingly, low-dose (≤ 2 Gy-equivalents) BrdU photolysis stimulated ERK1/2 phosphorylation whereas higher doses (≥ 5 Gy eq.) resulted in Em1/2 dephosphorylation. ERK1/2 phosphorylation was ATM-dependent, whereas dephosphorylation …
-
PPARγ agonism attenuates cocaine seeking behavior via association with ERK MAPK
… is thought to underlie relapse behaviors. ERK, a protein vital for learning and memory, is altered by cocaine use and abstinence. Our lab demonstrated PPARγ agonism rescued cognitive impairment in an animal model of Alzheimer’s disease and that this rescue involved ERK. Given the role of …
-
Dysregulated ERK signal pathway and immune profiles in Fragile X Syndrome
… of extracellular-signal regulated kinase (ERK), a nodal point for cell signaling cascades, in both neurons and thymocytes of fmr-1 KO mice. We further reported that early-phase kinetics of ERK activation in lymphocytes from human peripheral blood is delayed in a cohort of individuals with …
-
Identification of a Novel ERK 1/2-Interacting A-Kinase Anchoring Protein
… Mammalian RSP3 was found to interact with ERK2 through a yeast two-hybrid screen designed to identify interactors that have a higher affinity for the phosphorylated, active form of ERK2. Confirming this finding, the human homolog long form, RSP3H, co-immunoprecipitates with ERK1/2 in HEK293 …
-
Investigation of The Role of The Scaffold Protein Shc In Erk Signaling
… we focused on the role of Shc in the MAP kinase Erk signaling both prior to and post-growth factor stimulation. Prior to growth factor stimulation, we found Erk to be a direct interacting partner of Shc. The two proteins associate through a non-canonical interface. This interaction blocks the …
-
Crosstalk Between R1175 Methylation and Y1173 Phosphorylation Negatively Modulates Egfr-Mediated Erk Activation
… recruitment to EGFR and suppresses EGFR-mediated ERK activation, resulting in inhibition of cell proliferation, migration, and invasion of EGFR-expressing cells. Based on these findings, we provide the first link between arginine methylation and tyrosine phosphorylation and identify R1175 …
-
REGULATION OF RHOGAP DLC1 BY FAK, PP2A AND MEK/ERK IN CELL DYNAMICS
… involving the concerted action of Ras/Mek/Erk pathway, Focal adhesion kinase (FAK) and Protein phosphatase-2A (PP2A) to activate DLC1s GAP function. EGF stimulation not only leads to the phosphorylation of DLC1 but also that of FAK to inactivate it, thus allowing PP2A-mediated …
-
The crosstalk between the ERK and the cAMP signalling pathways in PC12 Cells
The extracellular-regulated kinase (ERK) signalling pathway is involved in the control of different biological processes such as survival, proliferation and differentiation. In PC12 cells, the ERK signalling pathway integrates different external stimuli: epidermal growth factor (EGF) stimulates the …
-
Role of Extracellular Signal-Regulated Kinase (ERK) in Regulation of Intestinal Epithelial Tight Junctions
<p>Evidence indicates that MAP kinase (ERK1/2) is involved in regulation of epithelial tight junctions. There are different opinions expressed by investigators as to whether ERK disrupts the junctions or protects them. ERK has also been demonstrated to mediate the EGF-caused protection of the …
-
ADAP1 Promotes Latent HIV-1 Reactivation by Tuning the KRAS-ERK-AP-1 Signaling-Transcriptional Axis
… T cell signaling through targeted activation of ERK-AP-1 axis. In primary CD4+ T cells which I have genetically ablated ADAP1, I show loss of ADAP1 function blunts gene expression programs in response to stimulation thereby reducing CD4+ T cell expansion and dampening latent HIV-1 reactivation. …
-
MEK1 binds βarrestin1 directly, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization.
… functions as an adaptor protein in the c-Raf/MEK/ERK cascade by interacting with c-Raf and ERK. In this study, I have shown that (1) β-arrestin1 can bind MEK1 directly, mediated at least in part by D26D29 of β-arrestin1 and R47K48R49 of MEK1. (2) Disruption of this association by mutagensis or …
-
Régulation de la prolifération et de la différenciation des cellules épithéliales intestinales par les cascades MEK/ERK et AMPc/PKA
… cascades de signalisation intracellulaires, MEK/ERK et AMPc/PKA, dans la prolifération et la différenciation des cellules épithéliales intestinales. Dans un premier temps, nous avons montré que la cascade MEK/ERK est nécessaire mais non suffisante à la prolifération des cellules épithéliales …
-
Eine neue Domäne der IL-6 Rezeptor β -Kette, gp130, vermittelt Zellwachstum und die Aktivierung der Kinasen Hck und Erk
… aktiviert. Ziel die-ser Arbeit war es, genauere Erkenntnisse über die genauen Mechanismen dieser Aktivierung zu gewinnen. Mittels Mutationsanalysen wurde eine „saure Domäne“ zwischen den Aminosäu-ren 771 und 811 von gp130 als Bindungsregion für die Src-Kinase Hck identifi-ziert. Dieses …
-
The Ups and Downs of MAP Kinase ERK: Modulation of Molecular Responses to Song in the Zebra Finch Auditory Forebrain
These studies demonstrate that ERK activity in the auditory forebrain reflects information about the familiarity and significance of a specific birdsong stimulus. Moreover, ERK activation appears to be necessary, but perhaps not sufficient, for triggering of an IEG response to song presentation. …
-
Activation of the Transient Receptor Potential Vanilloid-1 (TRPV1) channel mediates Extracellular Signal Regulated Kinase (ERK) phosphorylation via Beta-arrestin-2 signaling
… also acts as a signaling scaffold for the MAPK (ERK1/2) pathway which was described as an important nociceptive marker. In this thesis, several experimental approaches were employed to investigate TRPV1 signaling and to characterize whether β-arrestin-2 as well as ERK play a role downstream of …
-
Role of the PI-3K/Akt and ERK pathways in phencyclidine-induced neurotoxicity in neonatal rats and the protection by lithium and BDNF
… (PI-3K)/Akt and extracellular regulated kinase (ERK) pathways and suppressed activation of the pro-apoptotic factor, glycogen synthase kinase-3â (GSK-3â), evoked by PCP. Furthermore, blocking either the PI-3K/Akt or the ERK pathway abolished the protective effects of lithium and BDNF. …
Page 1 of 24