Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"ERGIC"”.
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An Examination of Experimentally Induced Changes in Ergic Tension Levels
Made available in DSpace on 2014-12-10T21:07:12Z (GMT). No. of bitstreams: 1 7206981.pdf: 7495086 bytes, checksum: 6e8fb2f91eba9bb34a7922b05f8324f3 (MD5) Previous issue date: 1971
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Altered GABA ergic system in the posterior hypothalamus of the spontaneously hypertensive rat
"Previous studies indicate a tonic GABAergic inhibitory mechanism in the posterior hypothalamus (PH) contributes to modulating cardiovascular activity. Blockade of GABA receptors on neurons in this area elicits an increase in sympathetic discharge, arterial pressure and heart rate. It has been …
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A Study of Ergic Tension Patterns Through the Effects of Water Deprivation in Humans
Made available in DSpace on 2014-12-03T23:50:19Z (GMT). No. of bitstreams: 1 0003988.pdf: 6746615 bytes, checksum: a55a71ce2682c5c062259019fa9cf5f9 (MD5) Previous issue date: 1952
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Investigation of enteric neuron and type 2 lymphocyte interactions at homeostasis and during Nippostrongylus brasiliensis infection
… data revealed one subset of enteric cholinergic neurons, termed NMU-ergic neurons, which express genes encoding known regulators of ILC2s (*Nmu*, *Calcb*, *Chat*) as well as molecules (*Il13ra1*, *Il4ra*, *Il7*) not previously implicated in intestinal neuro-immune interactions. Generation …
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Luminal calcium regulates membrane fusion in the early secretory pathway
… reticulum to Golgi intermediate compartment (ERGIC) in the periphery of the cell visualized using the markers rbet1 and p24. Depletion of luminal calcium also results in major kinetic defects of VSV-G transport to the Golgi, as well as reconstitution of the Golgi after it has been dispersed …
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Luminal calcium regulates membrane fusion in the early secretory pathway
… reticulum to Golgi intermediate compartment (ERGIC) in the periphery of the cell visualized using the markers rbet1 and p24. Depletion of luminal calcium also results in major kinetic defects of VSV-G transport to the Golgi, as well as reconstitution of the Golgi after it has been dispersed …
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CELLULAR AND MOLECULAR PATHWAYS CONTROLLING SARS-COV2 ASSEMBLY AND EGRESS
… occurs at the ER-Golgi intermediate compartment (ERGIC), also named vesicular-tubular cluster (VTC). Here, the structural proteins Spike (S), Membrane (M) and Envelope (E), after being translocated from the endoplasmic reticulum (ER) to the ERGIC, interact with the complex formed by viral RNA and …
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MCMV interferiert mit der MHC-Klasse-I-Antigenpräsentation
… nicht im „ER-Golgi intermediate compartment“ (ERGIC) / cis-Golgi, wie Wildtyp-H-2Kb. Es wird diskutiert, ob dies ein Hinweis auf einen aktiven Transportmechanismus von MHC-Klasse-I-Molekülen aus dem ER ins ERGIC ist. Neben der Untersuchung der Funktion von m152/gp40 aufgrund der Expression des …
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High frequency activity preceding epileptic seizures
… HFA; 5) synaptic transmission through glutamatergic and γ-aminobutyric acid-ergic synapses were not essential in HFA formation but they were related to the modulations of HFA. Our findings suggested the crucial role of HFA in the seizure genesis and the potential value in seizure prediction by …
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Exploring the Behavioural Effects of Compound-21 Using Novel Object Recognition and Object in Place Tests in Long Evans Rats
… parvalbumin (PV+) gamma-amino butyric acid (GABA)ergic interneurons of the medial prefrontal cortex (mPFC) would impair associative memory as measured by OiP. I showed that C21 did not affect either sex in NOR, or females in OiP. Male rats failed to exhibit robust discrimination in OiP following …
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CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX
… attention. The SOC receives a catecholaminergic and a serotonergic innervation from the locus coeruleus and the dorsal raphe respectively. While the physiological role of the noradrenergic input has yet to be defined, serotonin is involved in auditory temporal processing. Because Pb …
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CHRONIC LOW-LEVEL LEAD EXPOSURE AFFECTS THE MONOAMINERGIC SYSTEM IN THE MOUSE SUPERIOR OLIVARY COMPLEX
… attention. The SOC receives a catecholaminergic and a serotonergic innervation from the locus coeruleus and the dorsal raphe respectively. While the physiological role of the noradrenergic input has yet to be defined, serotonin is involved in auditory temporal processing. Because Pb …
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Analysis of the interaction between the 2C protein of parechoviruses and lipid droplets
… antiviral drugs. Viruses often rearrange the ER, ERGIC and Golgi to give a new membrane structures involved in viral replication and/or assembly. To improve our understanding of HPeV replication, we first studied the secretory pathway compartments and we found in HPeV-infected cells that the Golgi …
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BETA 2 NICOTINIC ACETYLCHOLINE RECEPTOR CONTRIBUTIONS TO ANXIETY-LIKE BEHAVIOR
… behavior during aging. Dysregulation of cholinergic tone can increase anxiety in the elderly, but little is known regarding beta2*nAChR contributions to anxiety in this population or where in the brain this may take place. These studies show that alpha4beta2*nAChR expression differentially …
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Die MHC-Klasse-I-regulatorische Funktion des 48 kDa Glykoproteins des murinen Cytomegalovirus
… Retention von MHC-Klasse-I-Molekülen im ERGIC/cis-Golgi über weitere Mechanismen, den Transport von MHC-Klasse-I-Molekülen an die Plasmamembran zu verhindern (Thäle et al., 1995; Ziegler et al., 1997). In der vorliegenden Arbeit konnte das MCMV Glykoprotein gp48, welches durch das in der …
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Structural insights into the GABAA receptor gating cycle
… is lacking. As a result, the mechanisms of GABA-ergic signalling, in physiologically meaningful environments and time scales, remain among the most important unknowns in molecular neuroscience. To address these issues, I first sought to identify optimal reconstitution environments for …
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Advances in Hybrid Evolutionary Computation for Continuous Optimization
… their composing algorithms thanks to the syn- ergic relationships yielded by the hybridization. This characteristic has been the main motivation for the studies that have been carried out in the development of this thesis. Each of these studies analyzes a different key factor in the combination …
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Chemogenetics, Induced Neurons and Pluripotent Stem Cells: Towards Advanced Gene and Cell Therapies Targeting Epilepsy
… (lt-NES), predominately differentiating to GABA-ergic neurons, displayed functional neuronal properties and certain rate of synaptic integration. In vivo studies showed that longer differentiation time (up to 24 weeks) was needed for the grafts to fully mature and extensively integrate into the …
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Synapse Dysfunction Induced by Autism Spectrum Disorder Associated Shank3 Mutations
… that occur in γ- aminobutyric acid (GABA)-ergic inhibitory synapses induced by up- or down-regulation of Shank3 expression or expression of ASD-associated mutations in Shank3. We specifically investigated changes in the expression level and density of GABAergic pre- and postsynaptic …
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CELLULAR AND MOLECULAR MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA
… upon chemotherapy treatment and relocates to the ERGIC compartment in proximity to STING, where STING activation by chemotherapy-induced DNA damage initiates a cascade leading to IFN signaling and cell death. Based on these findings, I initiated experiments to determine 10 whether IFI6-mediated …