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Showing 1 to 2 of 2 for “"ERCC1 protein"”.
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Role of DNA repair protein ERCC1 in skin cancer
… and a 1000-fold increased risk of skin cancer. ERCC1 is essential for the NER pathway where it acts in a complex with the XPF protein to make the incision 5' to the DNA lesion. The normal 1.1kb Ercc1 transcript is expressed in all tissues. Our group has discovered a second larger 1.5 kb …
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Expression of Excision Repair Cross-Complementation Group 1 Protein Predicts Poor Outcome in Patients with Small Cell Lung Cancer
BACKGROUND: Alterations in apoptosis-related proteins and DNA damage repair proteins are associated with resistance to chemotherapy or radiotherapy, which is the most important cause of treatment failure in small cell lung cancer (SCLC). PATIENTS AND METHODS: Pretreatment tumor biopsy specimens …