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Showing 1 to 18 of 18 for “"ERCC1"”.
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Role of DNA repair protein ERCC1 in skin cancer
… and a 1000-fold increased risk of skin cancer. ERCC1 is essential for the NER pathway where it acts in a complex with the XPF protein to make the incision 5' to the DNA lesion. The normal 1.1kb Ercc1 transcript is expressed in all tissues. Our group has discovered a second larger 1.5 kb …
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Expression of Excision Repair Cross-Complementation Group 1 Protein Predicts Poor Outcome in Patients with Small Cell Lung Cancer
… stage: 37) were analyzed for p53, bcl-2, bax and ERCC1 expression by immunohistochemistry. All patients were treated with platinum-based doublets. The most commonly used regimen was etoposide/cisplatin (50 patients). In patients with limited stage SCLC, thoracic irradiation was performed either …
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Prognostic Factor Analysis of Patients with Advanced Non-Small Cell Lung Cancer Treated with Palliative Chemotherapy
… stage IV were analyzed for p53, Bcl-2, Bax and ERCC1 expression by immunohistochemistry. All patients were treated with platinum-based third-generation doublet chemotherapy. RESULTS: High expression of p53, Bcl-2, Bax and ERCC1 were observed in 24 (48%), 8(16%), 32 (63%), 28 (55%) patients, …
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Expression of Bax Predicts Outcome in Advanced Gastric Cancer Patients Treated With 5-fluorouracil and Platinum Palliative Chemotherapy
… excision repair cross-complementation group 1 (ERCC1), and thymidylate synthase (TS) on clinical outcomes in patients with advanced gastric cancer treated with 5-fluorouracil (5-FU) and platinum palliative chemotherapy. Materials and Methods: One hundred and twenty-eight patients with metastatic …
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Gene expression of DNA repair proteins in colorectal cancer and medulloblastoma
… and Nthl1, the nucleotide excision repair gene Ercc1 and the mismatch repair gene Mlh1 in colorectal cancer (CRC) tumours and matched normal colon tissue. The project was then extended to analyse a further sixteen colon samples that focused on Neil3, Nthl1 and Ercc1, that encode DNA repair …
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Entwicklung von Verfahren zur Erkennung individueller Strahlenempfindlichkeit durch Analyse der Expression geeigneter Kandidatengene
… DNA-Reparatur-Genen (ATM, APEX1, BRCA1, BRCA2, ERCC1, MDM2, TP53 und TOP3A) von Krebspatienten vor einer Strahlentherapie sollte deshalb als möglicher Biomarker für eine Strahlenüberempfindlichkeit untersucht werden. In diesem Zusammenhang sollten zusätzlich Genvarianten in den Genen ERCC1, MDM2 …
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Regulation of structure-selective nucleases by the SLX4 scaffold in ICL repair and HJ resolution
… different structure-selective endonucleases: XPF-ERCC1, MUS81-EME1 and SLX1. The SLX4 complex has been shown to have essential roles in repair of DNA interstrand crosslinks (ICLs). In addition to its role in ICL repair, the SLX4 complex has the relatively unusual property of being able to cleave …
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비인강암 환자에서 Excision Repair Cross-Complementation Group1 단백의 과발현이 예후에 미치는 영향
… Evaluation 4 3. Immunohistochemical staining for ERCC1, TS and Bax 4 4. Statistical analysis 5 Ⅲ. RESULTS 7 1. Patients characteristics 7 2. Treatment response 8 3. Association of expression of drug resistance-related proteins with clinicopathologic charecteristics 9 4. Association between …
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Using <i>Drosophila melanogaster</i> as a Whole-Model Animal System to Elucidate the Mechanism of Action of Novel Anticancer Agents
… a key gene in the antioxidant pathway, and <i>Ercc1</i>, a DNA repair gene. Drosophila were microinjected with the oxidatively agents, An-Hq and An-Hq<sub>2</sub>, to determine toxicity. We compared the change in toxicity to traditional DNA modifying agents: cisplatin, chlorambucil, and …
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DNA crosslink repair safeguards genomic stability during pre-meiotic germ cell development
… role for the structure-specific endonuclease XPF-ERCC1 in Fanconi-mediated DNA crosslink repair during germ cell development in utero. Inactivation of Fanconi-mediated DNA repair results in an almost complete loss of gamete production in mice. This repair pathway is critical for the normal …
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Prognostic biomarkers for head and neck squamous carcinoma
… hypoxia including PTEN, Ku80, RadSl, XRCC1, ERCC1 and HEP-la was tested using immunohistochemistry staining IHC. The tested genes were found to be expressed at varying levels in HNSCC patients. Associations between the level of the expression and gender, site of origin, tumour …
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Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response
… the function the key DNA repair nuclease, XPF-ERCC1. This nuclease operates in the Fanconi Anaemia (FA) pathway and Nucleotide excision repair (NER). Unexpectedly, ablation of these two DNA repair pathways does not result in equivalent cellular or mouse phenotypes. However, these two pathways …
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Clinical resistance to platinum chemotherapy in ovarian cancer
… PCR was also used to investigate the levels of ERCC1 (excision-related cross complementation group 1) in 3 of these paired patient samples, which was found to be increased by an average of 14.4% +/-0.8% in 3 post-chemotherapy samples. In ten pre-chemotherapy and seven post-chemotherapy patient …
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DNA repair and sister chromatid exchange
… the catalytic subunit (DNA-PKcs), and Artemis. ERCC1 is a representative member of the final DNA repair pathway examined, nucleotide excision repair (NER). Lastly, I determined if/how DNA repair status can influence the ionizing radiation induced bystander effect (BSE). I was able to determine …
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Fluorescent detection of homologous recombination reveals the impact of genetic, physiological, and environmental factors on genomic stability
… to another. Additionally, FYDR mice deficient in ERCC1, a protein involved in several pathways including nucleotide excision repair and MMEJ, showed an increase in HR. We describe a possible model for this observation. HR is presumed to be largely limited to replicating cells; however, little is …
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Fanconi Anaemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mammalian development
… FA ICL repair incision complex (SLX4-XPF-ERCC1), I show that it can cleave intermediates of retrotransposition, aborting new integrations. I show that all stages of FA ICL repair, defective in the human disease FA, are required to prevent retrotransposition in vivo. I find that FA ICL …
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THE DNA DAMAGE CHECKPOINT REGULATES MISMATCH REPAIR COMPLEXES DURING SINGLE STRAND ANNEALING PATHWAY
… are removed by the Rad1 – Rad10 (human XPF – ERCC1) endonuclease complex together with Saw1 and Slx4. Furthermore, Slx4 with Rtt107 limits the binding of the DDC mediator Rad9/53BP1 in proximity of the DSB, reducing checkpoint signalling. We observed that the deletion of RAD9 gene rescues the …
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Heat stress: A risk factor for skin carcinogenesis
… using TaqMan probes for BAX, Survivin (BIRC5), ERCC1 and XPC genes, with Human 18S gene as the endogenous reference gene. Relative quantification of the expression levels of each transcript in each sample were calculated using the Delta-Delta CT method relative to untreated controls. A whole …