Global ETD Search
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Showing 1 to 7 of 7 for “"ERBB4"”.
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Characterization of Erbb4 Expression In Osteosarcoma
<p>ERBB4 (Her-4) is a member of the ERBB family of Class I receptor tyrosine kinases. ERBB4 is unique within the ERBB family for alternate splicing in its juxtamembrane and cytoplasmic regions, which produces four juxtamembrane isoforms and two cytoplasmic isoforms. The cleavable juxtamembrane …
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The Nrg Growth Factors and Their Receptor ErbB4 in the Developing Brain: Delineation of Nrg3 Expression and Neuritogenesis
… of growth factors (Nrg1-4) and their receptor, ErbB4, have been linked to mental illnesses considered to emerge as a result of abnormal neural development, such as schizophrenia, bipolar disorder, and depression. In the normal central nervous system (CNS), Nrg-ErbB ligand- receptor pairs …
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Differential Regulation of Synaptic Plasticity In Epilepsy
… in an activity-dependant manner and acts via ErbB4 tyrosine kinases to release dopamine (DA). In the sham condition, activation of NRG/ErbB4 signaling causes DA release which acts on D4 dopaminergic receptors (DARs) to block LTP. Similarly, application of an ErbB4 antagonist enhances LTP …
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Identification and characterization of genes expressed by the midbrain dopaminergic neurons
… factor, Olf-1/Ebf, and the neuregulin receptor, ErbB4. HNF3a is expressed in the precursors of the mDA neurons at E9 and continues to be expressed in the postmitotic cells until adulthood. Analyses of the mDA neurons from mice lacking HNF3a showed that HNF3a is not required for the early …
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Expression of Epidermal Growth Factor Receptor in hypopharyngeal cancer and Effect of EGF in Progression of hypopharyngeal cancer
… HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4). High levels of EGFR expression are correlated with poor prognosis and resistance to radiation therapy in a variety of cancers, mostly in head and neck squamous cell carcinoma (HNSCC). So we examined the expression of EGFR in hypopharyngeal …
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Experimental and computational analysis of epidermal growth factor receptor pathway phosphorylation dynamics
… with three close homologues: ErbB2, ErbB3 and ErbB4. ErbB1-3 receptors are frequently mutated, overexpressed or activated by autocrine or paracrine ligand production in solid tumors and have been the target of extensive drug discovery efforts. Multiple small molecule kinase inhibitors and …
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Her4 Promotes A Stem-Like Phenotype In Osteosarcoma
<p>Metastatic disease to the lungs is the primary cause of death for patients with pediatric osteosarcoma (OS). OS has a high degree of heterogeneity and genomic instability, making understanding the pathogenesis and drivers of metastasis of this disease challenging. In an effort to explain tumoral …